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Keyword

PDE2

Description: Phosphodiesterase 2, an enzyme that hydrolyzes cyclic nucleotides and regulates intracellular signaling in biological systems.
Wikidata ID: wiki/Q5864328
OpenAlex ID: keywords/pde2
Sildenafil: an orally active type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction.
1996 · M Boolell, M J Allen, et al. · PubMed · 1,068
cAMP and cGMP Signaling Cross-Talk
2007 · Manuela Zaccolo, Matthew A. Movsesian · Circulation Research · 360
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Inhibition of phosphodiesterase 2 increases neuronal cGMP, synaptic plasticity and memory performance
2004 · Frank G. Boess, Martin Hendrix, et al. · Neuropharmacology · 331
Exisulind induction of apoptosis involves guanosine 3',5'-cyclic monophosphate phosphodiesterase inhibition, protein kinase G activation, and attenuated beta-catenin.
2000 · W J Thompson, G A Piazza, et al. · PubMed · 305
Anti‐platelet therapy: phosphodiesterase inhibitors
2011 · Paolo Gresele, Stefania Momi, et al. · British Journal of Clinical Pharmacology · 304
Yeast pseudohyphal growth is regulated by GPA2, a G protein α homolog
1997 · Michael C. Lorenz, Joseph Heitman · The EMBO Journal · 295
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Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae.
1986 · P Sass, J Field, et al. · Proceedings of the National Academy of Sciences · 288
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Compartmentalized Phosphodiesterase-2 Activity Blunts β-Adrenergic Cardiac Inotropy via an NO/cGMP-Dependent Pathway
2005 · Marco Mongillo, Carlo G. Tocchetti, et al. · Circulation Research · 278
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Cyclic Guanosine Monophosphate Compartmentation in Rat Cardiac Myocytes
2006 · Liliana R.V. Castro, Ignacio Verde, et al. · Circulation · 274
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Selective phosphodiesterase inhibitors: a promising target for cognition enhancement
2008 · Olga A. H. Reneerkens, Kris Rutten, et al. · Psychopharmacology · 267
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Farnesol and dodecanol effects on the Candida albicans Ras1‐cAMP signalling pathway and the regulation of morphogenesis
2007 · Amber Davis‐Hanna, Amy E. Piispanen, et al. · Molecular Microbiology · 250
Reversal of Oxidative Stress-Induced Anxiety by Inhibition of Phosphodiesterase-2 in Mice
2008 · Anbrin Masood, Ahmed Nadeem, et al. · Journal of Pharmacology and Experimental Therapeutics · 223
Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae.
1987 · J Nikawa, P Sass, et al. · Molecular and Cellular Biology · 219
Gpa2p, a G-protein α-Subunit, Regulates Growth and Pseudohyphal Development in Saccharomyces cerevisiae via a cAMP-dependent Mechanism
1997 · Eric Kübler, Hans-Ulrich Mösch, et al. · Journal of Biological Chemistry · 193
Characterization and Functional Relevance of Cyclic Nucleotide Phosphodiesterase Isoenzymes of the Human Prostate
2001 · STEFAN ÜCKERT, ANDREA KÜTHE, et al. · The Journal of Urology · 192
The PDE1 -encoded Low-Affinity Phosphodiesterase in the Yeast Saccharomyces cerevisiae Has a Specific Function in Controlling Agonist-induced cAMP Signaling
1999 · Pingsheng Ma, Stefaan Wera, et al. · Molecular Biology of the Cell · 191
Characterization of the cyclic nucleotide phosphodiesterase subtypes involved in the regulation of the L‐type Ca2+ current in rat ventricular myocytes
1999 · Ignacio Verde, Grégoire Vandecasteele, et al. · British Journal of Pharmacology · 186
Improving Memory: A Role for Phosphodiesterases
2006 · A. Blokland, R. Schreiber, et al. · Current Pharmaceutical Design · 175
A cGMP-signaling pathway in a subset of olfactory sensory neurons
2000 · Mike R. Meyer, Albert Angele, et al. · Proceedings of the National Academy of Sciences · 174
Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes.
1989 · J V Swinnen, D R Joseph, et al. · Proceedings of the National Academy of Sciences · 172
cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes
2011 · Alessandra Stangherlin, Frank Gesellchen, et al. · Circulation Research · 166
Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure–activity relationships
2004 · Wun-Chang Ko, Chwen-Ming Shih, et al. · Biochemical Pharmacology · 164
Two DHH Subfamily 1 Proteins in Streptococcus pneumoniae Possess Cyclic Di-AMP Phosphodiesterase Activity and Affect Bacterial Growth and Virulence
2013 · Yinlan Bai, Jun Yang, et al. · Journal of Bacteriology · 161
Phosphodiesterase regulation of nitric oxide signaling
2007 · D KASS, E TAKIMOTO, et al. · Cardiovascular Research · 156
Cyclic GMP regulation of the L‐type Ca2+ channel current in human atrial myocytes
2001 · Grégoire Vandecasteele, Ignacio Verde, et al. · The Journal of Physiology · 151
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Works count: 583
Citation count: 17,290
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