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Keyword

PDE4B

Description: PDE4B is a gene encoding a cyclic nucleotide phosphodiesterase enzyme studied in molecular biology, neuroscience, and disease research.
Wikidata ID: wiki/Q18030407
OpenAlex ID: keywords/pde4b
DISC1 and PDE4B Are Interacting Genetic Factors in Schizophrenia That Regulate cAMP Signaling
2005 · J. Kirsty Millar, Benjamin S. Pickard, et al. · Science · 648
Behavioral Phenotypes of Disc1 Missense Mutations in Mice
2007 · Steven J. Clapcote, Tatiana V. Lipina, et al. · Neuron · 526
Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117)
2017 · T-K Clarke, M J Adams, et al. · Molecular Psychiatry · 440
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Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases
2004 · Graeme L. Card, Bruce P. England, et al. · Structure · 432
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Increased miR‐124‐3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons
2017 · Shan Huang, Xintong Ge, et al. · The FASEB Journal · 420
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
2002 · S.-L. Catherine Jin, Marco Conti · Proceedings of the National Academy of Sciences · 367
A Discriminating Messenger RNA Signature for Bipolar Disorder Formed by an Aberrant Expression of Inflammatory Genes in Monocytes
2008 · Roos C. Padmos, Manon H. J. Hillegers, et al. · Archives of General Psychiatry · 336
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Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways
2019 · Bing Huang, Zhanghua Chen, et al. · Cell · 308
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Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
2004 · James M O'Donnell, Han-Ting Zhang · Trends in Pharmacological Sciences · 307
A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
2004 · Kam Y.J Zhang, Graeme L Card, et al. · Molecular Cell · 300
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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
2002 · Annette Robichaud, Panagiota B. Stamatiou, et al. · Journal of Clinical Investigation · 267
Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
2002 · Annette Robichaud, Panagiota B. Stamatiou, et al. · Journal of Clinical Investigation · 259
Specific Role of Phosphodiesterase 4B in Lipopolysaccharide-Induced Signaling in Mouse Macrophages
2005 · S-L Catherine Jin, Linda Lan, et al. · The Journal of Immunology · 255
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Genetic Variants Associated With Anxiety and Stress-Related Disorders
2019 · Sandra M. Meier, Kalevi Trontti, et al. · JAMA Psychiatry · 239
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Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders
2023 · Alexander S. Hatoum, Sarah M. C. Colbert, et al. · Nature Mental Health · 238
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Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and [3H]rolipram binding autoradiography
2000 · S Pérez-Torres, X Miró, et al. · Journal of Chemical Neuroanatomy · 229
FTO-Dependent N 6 -Methyladenosine Modifications Inhibit Ovarian Cancer Stem Cell Self-Renewal by Blocking cAMP Signaling
2020 · Hao Huang, Yinu Wang, et al. · Cancer Research · 219
Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+and CD8+T‐lymphocytes: role in regulating proliferation and the biosynthesis of interleukin‐2
1996 · Mark A. Giembycz, Christopher J. Corrigan, et al. · British Journal of Pharmacology · 217
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Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect
1999 · James A. Cherry, Ronald L. Davis · The Journal of Comparative Neurology · 215
A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design
2005 · Graeme L Card, Landy Blasdel, et al. · Nature Biotechnology · 208
RNA Silencing Identifies PDE4D5 as the Functionally Relevant cAMP Phosphodiesterase Interacting with βArrestin to Control the Protein Kinase A/AKAP79-mediated Switching of the β2-Adrenergic Receptor to Activation of ERK in HEK293B2 Cells
2005 · Martin J. Lynch, George S. Baillie, et al. · Journal of Biological Chemistry · 207
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PGE1 stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases
2006 · Anna Terrin, Giulietta Di Benedetto, et al. · The Journal of Cell Biology · 184
Nonredundant Function of Phosphodiesterases 4D and 4B in Neutrophil Recruitment to the Site of Inflammation
2004 · Miyako Ariga, Barbara Neitzert, et al. · The Journal of Immunology · 181
Anxiogenic-Like Behavioral Phenotype of Mice Deficient in Phosphodiesterase 4B (PDE4B)
2007 · Han-Ting Zhang, Ying Huang, et al. · Neuropsychopharmacology · 179
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Chronic Antidepressant Administration Increases the Expression of cAMP-Specific Phosphodiesterase 4A and 4B Isoforms
1999 · Michihiro Takahashi, Rose Terwilliger, et al. · Journal of Neuroscience · 176
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Works count: 976
Citation count: 24,410
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