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Keyword

PDE4D

Description: A human protein-coding gene that encodes phosphodiesterase 4D, an enzyme studied in signaling, disease genetics, and physiology.
Wikidata ID: wiki/Q18030409
OpenAlex ID: keywords/pde4d
The gene encoding phosphodiesterase 4D confers risk of ischemic stroke
2003 · Solveig Gretarsdottir, Gudmar Thorleifsson, et al. · Nature Genetics · 564
Phosphodiesterase 4D Deficiency in the Ryanodine-Receptor Complex Promotes Heart Failure and Arrhythmias
2005 · Stephan E. Lehnart, Xander H.T. Wehrens, et al. · Cell · 517
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Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases
2004 · Graeme L. Card, Bruce P. England, et al. · Structure · 432
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Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety
2009 · Alex B Burgin, Olafur T Magnusson, et al. · Nature Biotechnology · 397
Genetics of ischaemic stroke
2007 · Martin Dichgans · The Lancet Neurology · 397
Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-α responses
2002 · S.-L. Catherine Jin, Marco Conti · Proceedings of the National Academy of Sciences · 367
Remodeling of ryanodine receptor complex causes “leaky” channels: A molecular mechanism for decreased exercise capacity
2008 · Andrew M. Bellinger, Steven Reiken, et al. · Proceedings of the National Academy of Sciences · 352
Oocyte Maturation Involves Compartmentalization and Opposing Changes of cAMP Levels in Follicular Somatic and Germ Cells: Studies Using Selective Phosphodiesterase Inhibitors
1996 · A. Tsafriri, Sang-Young Chun, et al. · Developmental Biology · 348
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Genome-Wide Association Studies: What Do They Teach Us about Asthma and Chronic Obstructive Pulmonary Disease?
2009 · H. Marike Boezen · Proceedings of the American Thoracic Society · 329
Genome-wide Association Analysis Identifies PDE4D as an Asthma-Susceptibility Gene
2009 · Blanca E. Himes, Gary M. Hunninghake, et al. · The American Journal of Human Genetics · 328
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Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
2004 · James M O'Donnell, Han-Ting Zhang · Trends in Pharmacological Sciences · 307
A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
2004 · Kam Y.J Zhang, Graeme L Card, et al. · Molecular Cell · 300
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A Comprehensive Evaluation of Potential Lung Function Associated Genes in the SpiroMeta General Population Sample
2011 · Ma'en Obeidat, Louise V. Wain, et al. · PLoS ONE · 293
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Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
2002 · Annette Robichaud, Panagiota B. Stamatiou, et al. · Journal of Clinical Investigation · 267
Deletion of phosphodiesterase 4D in mice shortens α2-adrenoceptor–mediated anesthesia, a behavioral correlate of emesis
2002 · Annette Robichaud, Panagiota B. Stamatiou, et al. · Journal of Clinical Investigation · 259
Specific Role of Phosphodiesterase 4B in Lipopolysaccharide-Induced Signaling in Mouse Macrophages
2005 · S-L Catherine Jin, Linda Lan, et al. · The Journal of Immunology · 255
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Genome-wide association of sleep and circadian phenotypes
2007 · Daniel J Gottlieb, George T O'Connor, et al. · BMC Medical Genetics · 243
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Phosphodiesterase 4D and Protein Kinase A Type II Constitute a Signaling Unit in the Centrosomal Area
2001 · Kristin A. Taskén, Kristin A. Taskén, et al. · Journal of Biological Chemistry · 240
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ERK2 Mitogen-activated Protein Kinase Binding, Phosphorylation, and Regulation of the PDE4D cAMP-specific Phosphodiesterases
2000 · Simon J. MacKenzie, George S. Baillie, et al. · Journal of Biological Chemistry · 238
Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice
1999 · S.-L. Catherine Jin, François J. Richard, et al. · Proceedings of the National Academy of Sciences · 232
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Phosphodiesterase-4D Knock-Out and RNA Interference-Mediated Knock-Down Enhance Memory and Increase Hippocampal Neurogenesis via Increased cAMP Signaling
2011 · Yun-Feng Li, Yu-Fang Cheng, et al. · Journal of Neuroscience · 231
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Antidepressant-like Profile and Reduced Sensitivity to Rolipram in Mice Deficient in the PDE4D Phosphodiesterase Enzyme
2002 · H Zhang · Neuropsychopharmacology · 229
Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and [3H]rolipram binding autoradiography
2000 · S Pérez-Torres, X Miró, et al. · Journal of Chemical Neuroanatomy · 229
Myomegalin Is a Novel Protein of the Golgi/Centrosome That Interacts with a Cyclic Nucleotide Phosphodiesterase
2001 · Ignacio Verde, Gudrun Pahlke, et al. · Journal of Biological Chemistry · 217
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Cyclic AMP phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement, and affect
1999 · James A. Cherry, Ronald L. Davis · The Journal of Comparative Neurology · 215
Works count: 1,227
Citation count: 29,840
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