Keyword

PDSS2

Description: A human protein-coding gene involved in coenzyme Q10 biosynthesis and studied in metabolic disorders and cancer biology.

Primary topic: Coenzyme Q10 studies and effects (45%)

Wikidata ID: wiki/Q18042892

OpenAlex ID: keywords/pdss2

Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging

2015 · Assaf Ben‐Meir, Eliezer Burstein, et al. · Aging Cell · 470

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Leigh Syndrome with Nephropathy and CoQ10 Deficiency Due to decaprenyl diphosphate synthase subunit 2 (PDSS2) Mutations

2006 · Luis Carlos López, Markus Schuelke, et al. · The American Journal of Human Genetics · 396

Genetic bases and clinical manifestations of coenzyme Q 10 (CoQ 10 ) deficiency

2014 · Maria Andrea Desbats, Giada Lunardi, et al. · Journal of Inherited Metabolic Disease · 218

Respiratory chain dysfunction and oxidative stress correlate with severity of primary CoQ 10 deficiency

2008 · Catarina M. Quinzii, Luis C. López, et al. · The FASEB Journal · 168

Metabolic programs of T cell tissue residency empower tumour immunity

2023 · Miguel Reina-Campos, Maximilian Heeg, et al. · Nature · 129

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Primary Coenzyme Q Deficiency in Pdss2 Mutant Mice Causes Isolated Renal Disease

2008 · Min Peng, Marni J. Falk, et al. · PLoS Genetics · 129

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Genetics of Coenzyme Q10 Deficiency

2014 · Mara Doimo, Maria A. Desbats, et al. · Molecular Syndromology · 115

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Human CoQ10 deficiencies

2008 · C. M. Quinzii, L. C. López, et al. · BioFactors · 105

Coenzyme Q10 supplementation rescues renal disease in Pdss2kd/kd mice with mutations in prenyl diphosphate synthase subunit 2

2008 · Ryoichi Saiki, Adam L. Lunceford, et al. · American Journal of Physiology-Renal Physiology · 87

PDSS2 Inhibits the Ferroptosis of Vascular Endothelial Cells in Atherosclerosis by Activating Nrf2

2021 · Kai Yang, Hejian Song, et al. · Journal of Cardiovascular Pharmacology · 83

Update on clinical aspects and treatment of selected vitamin‐responsive disorders II (riboflavin and CoQ10)

2012 · Rita Horvath · Journal of Inherited Metabolic Disease · 74

Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway

2016 · Marcello Ziosi, Ivano Di Meo, et al. · EMBO Molecular Medicine · 72

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Tissue‐specific oxidative stress and loss of mitochondria in CoQ‐deficient Pdss2 mutant mice

2012 · Catarina M. Quinzii, Caterina Garone, et al. · The FASEB Journal · 66

CoQ10 deficiency diseases in adults

2007 · Catarina M. Quinzii, Michio Hirano, et al. · Mitochondrion · 62

Mitochondrial Disease and the Kidney With a Special Focus on CoQ10 Deficiency

2020 · Anne M. Schijvens, Nicole C. van de Kar, et al. · Kidney International Reports · 54

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Co-Enzyme Q10 Supplementation Rescues Cumulus Cells Dysfunction in a Maternal Aging Model

2019 · Assaf Ben-Meir, Kyunga Kim, et al. · Antioxidants · 54

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Genetic susceptibility to caffeine intake and metabolism: a systematic review

2024 · Jazreel Ju-Li Low, Brendan Jen-Wei Tan, et al. · Journal of Translational Medicine · 53

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Targeting a Braf/Mapk pathway rescues podocyte lipid peroxidation in CoQ-deficiency kidney disease

2021 · Eriene-Heidi Sidhom, Choah Kim, et al. · Journal of Clinical Investigation · 48

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Probucol ameliorates renal and metabolic sequelae of primary CoQ deficiency in Pdss2 mutant mice

2011 · Marni J. Falk, Erzsebet Polyak, et al. · EMBO Molecular Medicine · 48

The Role of Sulfide Oxidation Impairment in the Pathogenesis of Primary CoQ Deficiency

2017 · Catarina M. Quinzii, Marta Luna-Sanchez, et al. · Frontiers in Physiology · 47

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Focal segmental glomerulosclerosis is associated with aPDSS2haplotype and, independently, with a decreased content of coenzyme Q10

2013 · David L. Gasser, Cheryl A. Winkler, et al. · American Journal of Physiology-Renal Physiology · 45

PDSS2 Deficiency Induces Hepatocarcinogenesis by Decreasing Mitochondrial Respiration and Reprogramming Glucose Metabolism

2018 · Yan Li, Shuhai Lin, et al. · Cancer Research · 41

A cis-Regulatory Mutation of PDSS2 Causes Silky-Feather in Chickens

2014 · Chungang Feng, Yu Gao, et al. · PLoS Genetics · 38

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Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood

2011 · Song Lu, Lin-Yu Lu, et al. · Neurobiology of Disease · 35

DNA Methylation Patterns from Peripheral Blood Separate Coronary Artery Disease Patients with and Without Heart Failure

2020 · Chris R. Bain*†, Mark Ziemann†, et al. · ESC Heart Failure · 33

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Works count: 114

Citation count: 3,112