Keyword

perforin

Description: Perforin is a pore-forming protein released by cytotoxic immune cells that helps destroy infected or abnormal target cells.

Primary topic: Immune Cell Function and Interaction (20%)

Wikidata ID: wiki/Q21103279

OpenAlex ID: keywords/perforin

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 · Vijay Shankaran, Hiroaki Ikeda, et al. · Nature · 2,895

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 · David Kägi, Birgit Ledermann, et al. · Nature · 1,758

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

2020 · Zhibin Zhang, Ying Zhang, et al. · Nature · 1,690

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

2003 · Michael R. Betts, Jason M. Brenchley, et al. · Journal of Immunological Methods · 1,587

Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated Cytotoxicity

1994 · David Kägi, Françoise Vignaux, et al. · Science · 1,516

Phenotypic and Functional Separation of Memory and Effector Human CD8+ T Cells

1997 · Dörte Hamann, Paul A. Baars, et al. · The Journal of Experimental Medicine · 1,362

TGF-β directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

2005 · Dori A. Thomas, Joan Massagué · Cancer Cell · 1,350

PDF

Perforin and granzymes: function, dysfunction and human pathology

2015 · Ilia Voskoboinik, James C. Whisstock, et al. · Nature reviews. Immunology · 1,318

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

2020 · Zhiwei Zhou, Huabin He, et al. · Science · 1,308

Functional significance of the perforin/granzyme cell death pathway

2002 · Joseph A. Trapani, Mark J. Smyth · Nature reviews. Immunology · 1,291

Lymphocyte-Mediated Cytotoxicity

2002 · John H. Russell, Timothy J. Ley · Annual Review of Immunology · 1,124

Microbial Flora Drives Interleukin 22 Production in Intestinal NKp46+ Cells that Provide Innate Mucosal Immune Defense

2008 · Naoko Satoh-Takayama, Christian A.J. Vosshenrich, et al. · Immunity · 1,096

PDF

An Antimicrobial Activity of Cytolytic T Cells Mediated by Granulysin

1998 · Steffen Stenger, Dennis A. Hanson, et al. · Science · 1,066

Cytolytic T-cell cytotoxicity is mediated through perforin and Fas lytic pathways

1994 · Bente Lowin, Michael Hahne, et al. · Nature · 1,051

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

2007 · Xuefang Cao, Sheng F. Cai, et al. · Immunity · 1,036

PDF

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

2003 · Erika L. Pearce, Alan C. Mullen, et al. · Science · 1,012

HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors

2002 · Stephen A. Migueles, Alisha C. Laborico, et al. · Nature Immunology · 1,005

Munc13-4 Is Essential for Cytolytic Granules Fusion and Is Mutated in a Form of Familial Hemophagocytic Lymphohistiocytosis (FHL3)

2003 · Jérôme Feldmann, Isabelle Callebaut, et al. · Cell · 943

PDF

Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients

2007 · Junliang Fu, Dongping Xu, et al. · Gastroenterology · 897

A choice of death - the signal-transduction of immune-mediated beta-cell apoptosis

2001 · D. L. Eizirik, T. Mandrup-Poulsen · Diabetologia · 889

PDF

HIV-Specific Cd8+ T Cells Produce Antiviral Cytokines but Are Impaired in Cytolytic Function

2000 · Victor Appay, Douglas F. Nixon, et al. · The Journal of Experimental Medicine · 871

PDF

Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis

2008 · Wen-Hung Chung, Shuen-Iu Hung, et al. · Nature Medicine · 841

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

2010 · Matthew E. Pipkin, Jilian A. Sacks, et al. · Immunity · 796

PDF

The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal

2003 · Judy Lieberman · Nature reviews. Immunology · 789

Functionally Distinct Subsets of CD1d-restricted Natural Killer T Cells Revealed by CD1d Tetramer Staining

2002 · Jenny E. Gumperz, Sachiko Miyake, et al. · The Journal of Experimental Medicine · 781

PDF

Works count: 9,059

Citation count: 331,000