Keyword

PERK

Description: A gene encoding an endoplasmic-reticulum stress sensor kinase, also known as EIF2AK3, studied in neurodegenerative disease and bone biology.

Primary topic: Endoplasmic Reticulum Stress and Disease (50%)

OpenAlex ID: keywords/perk

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

2012 · Claudio Hetz · Nature Reviews Molecular Cell Biology · 4,102

An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative Stress

2003 · Heather P. Harding, Yuhong Zhang, et al. · Molecular Cell · 3,326

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Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 · Heather P. Harding, Yuhong Zhang, et al. · Nature · 3,306

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 · Heather P Harding, Isabel Novoa, et al. · Molecular Cell · 3,278

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Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 · Anne Bertolotti, Yuhong Zhang, et al. · Nature Cell Biology · 2,863

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 · Heather P Harding, Yuhong Zhang, et al. · Molecular Cell · 2,018

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Autophagy Is Activated for Cell Survival after Endoplasmic ReticulumStress

2006 · Maiko Ogata, Shin-ichiro Hino, et al. · Molecular and Cellular Biology · 1,832

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

2001 · Isabel Novoa, Huiqing Zeng, et al. · The Journal of Cell Biology · 1,387

Translational control of gene expression

2000 · Nahum Sonenberg, John W.B. Hershey, et al. · Medical Entomology and Zoology · 1,378

Coping with stress: eIF2 kinases and translational control

2006 · R.C. Wek, H.-Y. Jiang, et al. · Biochemical Society Transactions · 1,289

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

2003 · Sara B. Cullinan, Donna Zhang, et al. · Molecular and Cellular Biology · 1,234

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 · Heather P. Harding, Huiqing Zeng, et al. · Molecular Cell · 1,217

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Endoplasmic reticulum stress in liver disease

2010 · Harmeet Malhi, Randal J. Kaufman · Journal of Hepatology · 1,177

The eIF2α/ATF4 pathway is essential for stress-induced autophagy gene expression

2013 · Wafa B’chir, Anne-Catherine Maurin, et al. · Nucleic Acids Research · 1,155

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Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells

2006 · Esther A. Obeng, Louise M. Carlson, et al. · Blood · 1,144

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Cell death induced by endoplasmic reticulum stress

2015 · Raffaella Iurlaro, Cristina Muñoz‐Pinedo · FEBS Journal · 1,065

Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1

2007 · Keisuke Yamamoto, Takashi Sato, et al. · Developmental Cell · 1,056

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The ER chaperone and signaling regulator GRP78/BiP as a monitor of endoplasmic reticulum stress

2005 · Amy S. Lee · Methods · 992

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

2006 · Y Kouroku, E Fujita, et al. · Cell Death and Differentiation · 932

The eIF2α kinases: their structures and functions

2013 · Neysan Donnelly, Adrienne M. Gorman, et al. · Cellular and Molecular Life Sciences · 859

PERK is required at the ER-mitochondrial contact sites to convey apoptosis after ROS-based ER stress

2012 · T Verfaillie, N Rubio, et al. · Cell Death and Differentiation · 852

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Mechanisms of pre‐apoptotic calreticulin exposure in immunogenic cell death

2009 · Theocharis Panaretakis, Oliver Kepp, et al. · The EMBO Journal · 845

EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

2000 · Marc Delépine, Marc Nicolino, et al. · Nature Genetics · 814

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

2012 · Abhishek D Garg, Dmitri V Krysko, et al. · The EMBO Journal · 798

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PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress

2004 · Sara B. Cullinan, J. Alan Diehl · Journal of Biological Chemistry · 745

Works count: 4,911

Citation count: 179,300