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PHOX2B
Description:
A human protein-coding gene involved in the development and function of autonomic nervous system circuits.
Primary topic:
Neuroscience of respiration and sleep (31%)
Related topics:
Neuroscience of respiration and sleep (31%),
Neuroblastoma Research and Treatments (21%),
Developmental Biology and Gene Regulation (11%),
Congenital gastrointestinal and neural anomalies (8%)
Wikidata ID:
wiki/Q14905595
OpenAlex ID:
keywords/phox2b
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
2007
·
John D Rioux
, Ramnik J Xavier
, et al.
·
Nature Genetics
·
1,769
The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives
1999
·
Alexandre Pattyn
, Xavier Morin
, et al.
·
Nature
·
877
Polyalanine expansion and frameshift mutations of the paired-like homeobox gene PHOX2B in congenital central hypoventilation syndrome
2003
·
Jeanne Amiel
, Béatrice Laudier
, et al.
·
Nature Genetics
·
857
Expression and interactions of the two closely related homeobox genes Phox2a and Phox2b during neurogenesis
1997
·
Alexandre Pattyn
, Xavier Morin
, et al.
·
Development
·
582
SOX10 Maintains Multipotency and Inhibits Neuronal Differentiation of Neural Crest Stem Cells
2003
·
Jaesang Kim
, Liching Lo
, et al.
·
Neuron
·
581
PDF
Heterogeneity of neuroblastoma cell identity defined by transcriptional circuitries
2017
·
Valentina Boeva
, Caroline Louis-Brennetot
, et al.
·
Nature Genetics
·
496
Enteric nervous system development: migration, differentiation, and disease
2013
·
Jonathan I. Lake
, Robert O. Heuckeroth
·
American Journal of Physiology-Gastrointestinal and Liver Physiology
·
383
Idiopathic congenital central hypoventilation syndrome: Analysis of genes pertinent to early autonomic nervous system embryologic development and identification of mutations in PHOX2b
2003
·
Debra E. Weese‐Mayer
, Elizabeth M. Berry‐Kravis
, et al.
·
American Journal of Medical Genetics Part A
·
383
Molecular targeting therapies for neuroblastoma: Progress and challenges
2020
·
Atif Zafar
, Wei Wang
, et al.
·
Medicinal Research Reviews
·
381
PDF
Expression of Phox2b by Brainstem Neurons Involved in Chemosensory Integration in the Adult Rat
2006
·
Ruth L. Stornetta
, Thiago S. Moreira
, et al.
·
Journal of Neuroscience
·
378
PDF
Germline Mutations of the Paired–Like Homeobox 2B (PHOX2B) Gene in Neuroblastoma
2004
·
Delphine Trochet
, Franck Bourdeaut
, et al.
·
The American Journal of Human Genetics
·
360
Phox2bcontrols the development of peripheral chemoreceptors and afferent visceral pathways
2003
·
Stéphane Dauger
, Alexandre Pattyn
, et al.
·
Development
·
321
A human mutation in Phox2b causes lack of CO 2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons
2008
·
Véronique Dubreuil
, Nélina Ramanantsoa
, et al.
·
Proceedings of the National Academy of Sciences
·
315
PDF
Bone Morphogenetic Proteins Are Required In Vivo for the Generation of Sympathetic Neurons
1999
·
Carolin Schneider
, Helmut Wicht
, et al.
·
Neuron
·
302
PDF
Congenital Central Hypoventilation Syndrome
2006
·
Elizabeth M. Berry-Kravis
, Lili Zhou
, et al.
·
American Journal of Respiratory and Critical Care Medicine
·
293
PHOX2B mutations and polyalanine expansions correlate with the severity of the respiratory phenotype and associated symptoms in both congenital and late onset Central Hypoventilation syndrome
2004
·
I Matera
, T Bachetti
, et al.
·
Journal of Medical Genetics
·
291
PDF
Germline PHOX2B Mutation in Hereditary Neuroblastoma
2004
·
Yael P. Mosse
, Marci Laudenslager
, et al.
·
The American Journal of Human Genetics
·
285
PDF
Selective gene dependencies in MYCN-amplified neuroblastoma include the core transcriptional regulatory circuitry
2018
·
Adam D. Durbin
, Mark W. Zimmerman
, et al.
·
Nature Genetics
·
283
PDF
The developmental etiology and pathogenesis of Hirschsprung disease
2013
·
Naomi E. Butler Tjaden
, Paul A. Trainor
·
Translational research
·
283
The enteric nervous system
2012
·
Valentina Sasselli
, Vassilis Pachnis
, et al.
·
Developmental Biology
·
271
PHOX2B Genotype Allows for Prediction of Tumor Risk in Congenital Central Hypoventilation Syndrome
2005
·
Delphine Trochet
, Louise M. O'Brien
, et al.
·
The American Journal of Human Genetics
·
250
Phox2 genes — from patterning to connectivity
2002
·
Jean-François Brunet
, Alexandre Pattyn
·
Current Opinion in Genetics & Development
·
245
Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Presenting in Childhood
2007
·
Diego Ize-Ludlow
, Juliette A. Gray
, et al.
·
PEDIATRICS
·
239
Development of Noradrenergic Neurons in the Zebrafish Hindbrain Requires BMP, FGF8, and the Homeodomain Protein Soulless/Phox2a
1999
·
Su Guo
, Jennifer Brush
, et al.
·
Neuron
·
234
PDF
Control of hindbrain motor neuron differentiation by the homeobox genePhox2b
2000
·
Alexandre Pattyn
, Marie-Rose Hirsch
, et al.
·
Development
·
228
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Works count:
1,133
Citation count:
33,430
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