Keyword

PI3Kα

Description: The alpha isoform of phosphoinositide 3-kinase, a lipid-signaling enzyme involved in cellular growth, survival, and cancer biology.

Primary topic: PI3K/AKT/mTOR signaling in cancer (50%)

OpenAlex ID: keywords/pi3kalpha

Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients

2009 · Bahriye Aktas, Mitra Tewes, et al. · Breast Cancer Research · 736

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Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

2000 · Michael E. Pacold, Sabine Suire, et al. · Cell · 602

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Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

2002 · Michael A. Crackower, Gavin Y. Oudit, et al. · Cell · 576

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The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations

2007 · Chuan-Hsiang Huang, Diana Mandelker, et al. · Science · 561

Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor

2022 · Jill Hallin, Vickie Bowcut, et al. · Nature Medicine · 532

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PI3K inhibitors are finally coming of age

2021 · Bart Vanhaesebroeck, Matthew W. D. Perry, et al. · Nature Reviews Drug Discovery · 476

Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit

2007 · Nabil Miled, Ying Yan, et al. · Science · 412

The interplay of ROS and the PI3K/Akt pathway in autophagy regulation

2021 · Lakhan Kma, Taranga Jyoti Baruah · Biotechnology and Applied Biochemistry · 396

Phosphatidylinositol 3-Kinase Inhibition by Copanlisib in Relapsed or Refractory Indolent Lymphoma

2017 · Martin Dreyling, Armando Santoro, et al. · Journal of Clinical Oncology · 395

A frequent kinase domain mutation that changes the interaction between PI3Kα and the membrane

2009 · Diana Mandelker, Sandra B. Gabelli, et al. · Proceedings of the National Academy of Sciences · 295

Expression of stem cell and epithelial-mesenchymal transition markers in primary breast cancer patients with circulating tumor cells

2012 · Sabine Kasimir-Bauer, Oliver Hoffmann, et al. · Breast Cancer Research · 284

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PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

2017 · Eneda Toska, Hatice U. Osmanbeyoglu, et al. · Science · 267

BAY 80-6946 Is a Highly Selective Intravenous PI3K Inhibitor with Potent p110α and p110δ Activities in Tumor Cell Lines and Xenograft Models

2013 · Ningshu Liu, Bruce R. Rowley, et al. · Molecular Cancer Therapeutics · 259

Feedback Suppression of PI3Kα Signaling in PTEN-Mutated Tumors Is Relieved by Selective Inhibition of PI3Kβ

2014 · Sarit Schwartz, John Wongvipat, et al. · Cancer Cell · 247

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Discovery of a Potent, Selective, and Orally Available Class I Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Kinase Inhibitor (GDC-0980) for the Treatment of Cancer

2011 · Daniel P. Sutherlin, Linda Bao, et al. · Journal of Medicinal Chemistry · 219

PIK3CA in cancer: The past 30 years

2019 · Rand Arafeh, Yardena Samuels · Seminars in Cancer Biology · 217

ZSTK474 is an ATP‐competitive inhibitor of class I phosphatidylinositol 3 kinase isoforms

2007 · Dexin Kong, Takao Yamori · Cancer Science · 166

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Potent efficacy of combined PI3K/mTOR and JAK or ABL inhibition in murine xenograft models of Ph-like acute lymphoblastic leukemia

2016 · Sarah K. Tasian, David T. Teachey, et al. · Blood · 164

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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα

2022 · Emily J. Hanan, Marie-Gabrielle Braun, et al. · Journal of Medicinal Chemistry · 159

A small-molecule PI3Kα activator for cardioprotection and neuroregeneration

2023 · Grace Q. Gong, Benoit Bilanges, et al. · Nature · 145

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Non-redundant Roles of Phosphoinositide 3-Kinase Isoforms α and β in Glycoprotein VI-induced Platelet Signaling and Thrombus Formation

2009 · Karen Gilio, Imke C.A. Munnix, et al. · Journal of Biological Chemistry · 137

Role of Phosphoinositide 3-Kinase β in Glycoprotein VI-mediated Akt Activation in Platelets

2009 · Soochong Kim, Pierre Mangin, et al. · Journal of Biological Chemistry · 134

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A specific function for phosphatidylinositol 3-kinase α (p85α-p110α) in cell survival and for phosphatidylinositol 3-kinase β (p85α-p110β) in de novo DNA synthesis of human colon carcinoma cells

2000 · Christine Bénistant, H Chapuis, et al. · Oncogene · 129

PI3K/mTOR Dual Inhibitor VS-5584 Preferentially Targets Cancer Stem Cells

2014 · Vihren N. Kolev, Quentin G. Wright, et al. · Cancer Research · 127

Cellular protection using Flt3 and PI3Kα inhibitors demonstrates multiple mechanisms of oxidative glutamate toxicity

2014 · Yunyi Kang, Stefano Tiziani, et al. · Nature Communications · 127

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Works count: 874

Citation count: 17,340