Keyword

PKM2

Description: PKM2 is the M2 isoform of pyruvate kinase, an enzyme involved in glycolysis and cellular metabolism, frequently studied in cancer biology.

Primary topic: Cancer, Hypoxia, and Metabolism (30%)

Wikidata ID: wiki/Q18030568

OpenAlex ID: keywords/pkm2

Stable Isotope Labeling by Amino Acids in Cell Culture, SILAC, as a Simple and Accurate Approach to Expression Proteomics

2002 · Shao-En Ong, Blagoy Blagoev, et al. · Molecular & Cellular Proteomics · 5,570

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The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

2008 · Heather R. Christofk, Matthew G. Vander Heiden, et al. · Nature · 2,814

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

2011 · Weibo Luo, Hongxia Hu, et al. · Cell · 1,460

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Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

2015 · Eva M. Palsson-McDermott, Anne M. Curtis, et al. · Cell Metabolism · 1,392

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Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

2011 · Dimitrios Anastasiou, George Poulogiannis, et al. · Science · 1,192

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

2009 · Charles J. David, Mo Chen, et al. · Nature · 1,179

Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation

2011 · Weiwei Yang, Yan Xia, et al. · Nature · 1,029

Pyruvate kinase M2 is a phosphotyrosine-binding protein

2008 · Heather R. Christofk, Matthew G. Vander Heiden, et al. · Nature · 995

Targeting cellular metabolism to improve cancer therapeutics

2013 · Y Zhao, E B Butler, et al. · Cell Death and Disease · 992

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ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

2012 · Weiwei Yang, Yanhua Zheng, et al. · Nature Cell Biology · 918

Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer’s disease

2022 · Rui-Yuan Pan, Lin He, et al. · Cell Metabolism · 855

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

2012 · Weiwei Yang, Yan Xia, et al. · Cell · 846

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

2012 · Dimitrios Anastasiou, Yimin Yu, et al. · Nature Chemical Biology · 813

Pyruvate kinase type M2 and its role in tumor growth and spreading

2005 · Sybille Mazurek, C. Bruce Boschek, et al. · Seminars in Cancer Biology · 812

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

2011 · Amparo Wolf, Sameer Agnihotri, et al. · The Journal of Experimental Medicine · 788

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Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

2009 · Taro Hitosugi, Sumin Kang, et al. · Science Signaling · 784

HIF1α and metabolic reprogramming in inflammation

2016 · Sarah E. Corcoran, Luke A.J. O’Neill · Journal of Clinical Investigation · 782

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Pyruvate Kinase M2 Regulates Gene Transcription by Acting as a Protein Kinase

2012 · Xueliang Gao, Haizhen Wang, et al. · Molecular Cell · 770

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A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth

2017 · Jin-Zhou Huang, Min Chen, et al. · Molecular Cell · 709

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Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma

2020 · Jiao Feng, Jingjing Li, et al. · Journal of Experimental & Clinical Cancer Research · 702

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Pyruvate kinase type M2: A key regulator of the metabolic budget system in tumor cells

2010 · Sybille Mazurek · The International Journal of Biochemistry & Cell Biology · 692

Serine is a natural ligand and allosteric activator of pyruvate kinase M2

2012 · Barbara Chaneton, Petra Hillmann, et al. · Nature · 660

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

2010 · Matthew G. Vander Heiden, Jason W. Locasale, et al. · Science · 635

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Characterization of the Inflammatory Response to Severe COVID-19 Illness

2020 · Oliver J. McElvaney, Natalie L. McEvoy, et al. · American Journal of Respiratory and Critical Care Medicine · 628

Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth

2011 · Lei Lv, Dong Li, et al. · Molecular Cell · 610

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Works count: 5,539

Citation count: 151,700