Keyword

polyol pathway

Description: A biochemical pathway that converts glucose to sorbitol and then fructose, with relevance to diabetes and its complications.

Primary topic: Aldose Reductase and Taurine (44%)

Wikidata ID: wiki/Q7226667

OpenAlex ID: keywords/polyol-pathway

Oxidative Stress and Diabetic Complications

2010 · Ferdinando Giacco, Michael Brownlee · Circulation Research · 5,448

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

2002 · Joseph L. Evans, Ira D. Goldfine, et al. · Endocrine Reviews · 2,232

Oxidative Stress and Diabetic Vascular Complications

1996 · Dario Giugliano, Anthonio Ceriello, et al. · Diabetes Care · 1,931

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

2008 · Josephine M. Forbes, Melinda T. Coughlan, et al. · Diabetes · 1,202

Endothelial dysfunction in diabetes

2000 · An S De Vriese, Tony J Verbeuren, et al. · British Journal of Pharmacology · 1,165

Obesity, Oxidative Stress, Adipose Tissue Dysfunction, and the Associated Health Risks: Causes and Therapeutic Strategies

2015 · Prasenjit Manna, Sushil K. Jain · Metabolic Syndrome and Related Disorders · 1,145

Oxidative stress and diabetic retinopathy: Molecular mechanisms, pathogenetic role and therapeutic implications

2020 · Qingzheng Kang, Chunxue Yang · Redox Biology · 1,068

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Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress

2006 · Anabela P. Rolo, Carlos M. Palmeira · Toxicology and Applied Pharmacology · 1,007

Sorbitol, Phosphoinositides, and Sodium-Potassium-ATPase in the Pathogenesis of Diabetic Complications

1987 · Jeffrey S. Flier, Lisa H. Underhill, et al. · New England Journal of Medicine · 897

Hyperglycemia and Oxidative Stress: An Integral, Updated and Critical Overview of Their Metabolic Interconnections

2023 · Patricia González, Pedro Lozano, et al. · International Journal of Molecular Sciences · 783

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Inflammation and the pathogenesis of diabetic nephropathy

2012 · Jun Wada, Hirofumi Makino · Clinical Science · 777

Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases

2013 · Teresa Fiorentino, Annamaria Prioletta, et al. · Current Pharmaceutical Design · 766

The Sorbitol Pathway and the Complications of Diabetes

1973 · Philip R. Steinmetz, Christine Balko, et al. · New England Journal of Medicine · 760

New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis

2018 · Ting Yuan, Ting Yang, et al. · Redox Biology · 743

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New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant Therapy

2003 · Antonio Ceriello · Diabetes Care · 734

Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy

2001 · N. E. Cameron, S. E. M. Eaton, et al. · Diabetologia · 701

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Chronic hyperglycemia mediated physiological alteration and metabolic distortion leads to organ dysfunction, infection, cancer progression and other pathophysiological consequences: An update on glucose toxicity

2018 · Biplab Giri, Sananda Dey, et al. · Biomedicine & Pharmacotherapy · 636

Contribution of Polyol Pathway to Diabetes-Induced Oxidative Stress

2003 · Stephen S.M. Chung, Eric C.M. Ho, et al. · Journal of the American Society of Nephrology · 610

Molecular pathways associated with oxidative stress in diabetes mellitus

2018 · Osasenaga Macdonald Ighodaro · Biomedicine & Pharmacotherapy · 557

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The pivotal role of glucose metabolism in determining oocyte developmental competence

2010 · Melanie L Sutton-McDowall, Robert B Gilchrist, et al. · Reproduction · 544

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Contributions of polyol pathway to oxidative stress in diabetic cataract

1999 · ALAN Y. W. LEE, STEPHEN S. M. CHUNG · The FASEB Journal · 534

Role of Aldose Reductase and Oxidative Damage in Diabetes and the Consequent Potential for Therapeutic Options

2005 · Satish K. Srivastava, Kota V. Ramana, et al. · Endocrine Reviews · 529

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Glycation, Inflammation, and RAGE

2003 · Shi Fang Yan, Ravichandran Ramasamy, et al. · Circulation Research · 513

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The role of protein kinase C activation and the vascular complications of diabetes

2007 · N DASEVCIMEN, G KING · Pharmacological Research · 495

Mechanism of diabetic neuropathy: Where are we now and where to go?

2010 · Soroku Yagihashi, Hiroki Mizukami, et al. · Journal of Diabetes Investigation · 486

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Works count: 3,205

Citation count: 123,500