Keyword

polyplexes

Description: Complexes formed when positively charged polymers bind nucleic acids, used as nonviral vectors for gene delivery.

Primary topic: RNA Interference and Gene Delivery (81%)

OpenAlex ID: keywords/polyplexes

The dawning era of polymer therapeutics

2003 · Ruth Duncan · Nature Reviews Drug Discovery · 3,272

Uptake Pathways and Subsequent Intracellular Trafficking in Nonviral Gene Delivery

2006 · Ikramy A. Khalil, Kentaro Kogure, et al. · Pharmacological Reviews · 1,241

Delivering CRISPR: a review of the challenges and approaches

2018 · Christopher A. Lino, Jason C. Harper, et al. · Drug Delivery · 1,183

Polymer Therapeutics: Concepts and Applications

2006 · Rainer Haag, Felix Kratz · Angewandte Chemie International Edition · 1,117

Chloride Accumulation and Swelling in Endosomes Enhances DNA Transfer by Polyamine-DNA Polyplexes

2003 · N.D. Sonawane, Francis C. Szoka, et al. · Journal of Biological Chemistry · 1,081

Cationic Polymer Based Gene Delivery Systems

2000 · Stefaan C. De Smedt, Joseph Demeester, et al. · Pharmaceutical Research · 884

Recent advances in rational gene transfer vector design based on poly(ethylene imine) and its derivatives

2005 · Michael Neu, Dagmar Fischer, et al. · The Journal of Gene Medicine · 866

Role of clathrin- and caveolae-mediated endocytosis in gene transfer mediated by lipo- and polyplexes

2005 · Joanna Rejman, Alessandra Bragonzi, et al. · Molecular Therapy · 852

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Cyclodextrin-based supramolecular architectures: Syntheses, structures, and applications for drug and gene delivery

2008 · Jun Li, Xian Jun Loh · Advanced Drug Delivery Reviews · 787

The Possible “Proton Sponge ” Effect of Polyethylenimine (PEI) Does Not Include Change in Lysosomal pH

2012 · Rikke V Benjaminsen, Maria A Mattebjerg, et al. · Molecular Therapy · 740

PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles

2004 · Swaroop Mishra, Paul Webster, et al. · European Journal of Cell Biology · 731

Gene delivery by lipoplexes and polyplexes

2010 · Conchita Tros de Ilarduya, Yan Sun, et al. · European Journal of Pharmaceutical Sciences · 627

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

2015 · Ulrich Lächelt, Ernst Wagner · Chemical Reviews · 603

Cationic lipids, lipoplexes and intracellular delivery of genes

2006 · Luc Wasungu, Dick Hoekstra · Journal of Controlled Release · 596

Recent Advances in Nonviral Vectors for Gene Delivery

2011 · Xia Guo, Leaf Huang · Accounts of Chemical Research · 585

Sheddable Coatings for Long-Circulating Nanoparticles

2007 · Birgit Romberg, Wim E. Hennink, et al. · Pharmaceutical Research · 556

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Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers

2009 · Patrick Midoux, Chantal Pichon, et al. · British Journal of Pharmacology · 548

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Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus

2000 · S Brunner, T Sauer, et al. · Gene Therapy · 534

Chitosan as a nonviral gene delivery system. Structure–property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo

2001 · M Köping-Höggård, I Tubulekas, et al. · Gene Therapy · 532

Polymeric nanomedicine for cancer therapy

2007 · Jae Hyung Park, Seulki Lee, et al. · Progress in Polymer Science · 504

Poly(2‐oxazoline)s as Polymer Therapeutics

2012 · Robert Luxenhofer, Yingchao Han, et al. · Macromolecular Rapid Communications · 468

Formation and Intracellular Trafficking of Lipoplexes and Polyplexes

2005 · Abdelatif Elouahabi, Jean-Marie Ruysschaert · Molecular Therapy · 464

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Polymeric nanoparticles for targeted treatment in oncology: current insights

2015 · Medha D Joshi, Vandana Patravale, et al. · International Journal of Nanomedicine · 446

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Structure−Activity Relationships of Water-Soluble Cationic Methacrylate/Methacrylamide Polymers for Nonviral Gene Delivery

1999 · Petra van de Wetering, Ed E. Moret, et al. · Bioconjugate Chemistry · 428

Mechanism of Polyplex- and Lipoplex-Mediated Delivery of Nucleic Acids: Real-Time Visualization of Transient Membrane Destabilization without Endosomal Lysis

2013 · Zia ur Rehman, Dick Hoekstra, et al. · ACS Nano · 398

Works count: 2,404

Citation count: 90,770