Keyword

PPARα

Description: PPARα is a nuclear receptor protein and transcription factor that regulates lipid metabolism and related gene expression in mammals.

Primary topic: Peroxisome Proliferator-Activated Receptors (30%)

Wikidata ID: wiki/Q18030677

OpenAlex ID: keywords/pparalpha

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects

2003 · Toshimasa Yamauchi, Junji Kamon, et al. · Nature · 3,175

Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults--The Evidence Report. National Institutes of Health.

1998 · Anna Meiliana, Andi Wijaya · PubMed · 2,737

The Mechanisms of Action of PPARs

2002 · Joel Berger, David E. Moller · Annual Review of Medicine · 2,656

Adiponectin and Adiponectin Receptors

2005 · Takashi Kadowaki, Toshimasa Yamauchi · Endocrine Reviews · 2,627

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Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat

1996 · O Braissant, F Foufelle, et al. · Endocrinology · 2,217

Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ

1997 · Steven A. Kliewer, Scott S. Sundseth, et al. · Proceedings of the National Academy of Sciences · 2,164

Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ

1997 · Barry Marc Forman, Jasmine Chen, et al. · Proceedings of the National Academy of Sciences · 2,115

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 · Steven A. Kliewer, James M. Lenhard, et al. · Cell · 2,030

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Mechanism of Action of Fibrates on Lipid and Lipoprotein Metabolism

1998 · Bart Staels, Jean Dallongeville, et al. · Circulation · 1,786

Targeted Disruption of the α Isoform of the Peroxisome Proliferator-Activated Receptor Gene in Mice Results in Abolishment of the Pleiotropic Effects of Peroxisome Proliferators

1995 · Susanna S.-T. Lee, Thierry Pineau, et al. · Molecular and Cellular Biology · 1,655

Peroxisome proliferator–activated receptor α mediates the adaptive response to fasting

1999 · Sander Kersten, Josiane Seydoux, et al. · Journal of Clinical Investigation · 1,648

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PPARs and the complex journey to obesity

2004 · Ronald M Evans, Grant D Barish, et al. · Nature Medicine · 1,627

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

2014 · Michal Pawlak, Philippe Lefebvre, et al. · Journal of Hepatology · 1,572

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Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

2007 · Takeshi Inagaki, Paul Dutchak, et al. · Cell Metabolism · 1,500

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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

2007 · Michael K. Badman, Pavlos Pissios, et al. · Cell Metabolism · 1,493

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Differential expression and activation of a family of murine peroxisome proliferator-activated receptors.

1994 · S A Kliewer, B M Forman, et al. · Proceedings of the National Academy of Sciences · 1,400

The PPARα–leukotriene B4 pathway to inflammation control

1996 · Pallavi R. Devchand, Hansjörg Keller, et al. · Nature · 1,346

Lipotoxic heart disease in obese rats: Implications for human obesity

2000 · Yan-Ting Zhou, Paul Grayburn, et al. · Proceedings of the National Academy of Sciences · 1,264

Fatty Acids, Eicosanoids, and Hypolipidemic Agents Identified as Ligands of Peroxisome Proliferator-Activated Receptors by Coactivator-Dependent Receptor Ligand Assay

1997 · Grigorios Krey, Olivier Braissant, et al. · Molecular Endocrinology · 1,221

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Peroxisome proliferator-activated receptor a target genes

2004 · S. Mandard, M. M�ller, et al. · Cellular and Molecular Life Sciences · 1,218

Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression

1996 · K Schoonjans, B Staels, et al. · Journal of Lipid Research · 1,216

Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications - a review

2014 · Bogna Grygiel-Górniak · Nutrition Journal · 1,201

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The Coactivator PGC-1 Cooperates with Peroxisome Proliferator-Activated Receptor α in Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes

2000 · Rick B. Vega, Janice M. Huss, et al. · Molecular and Cellular Biology · 1,194

PPARγ: a Nuclear Regulator of Metabolism, Differentiation, and Cell Growth

2001 · Evan D. Rosen, Bruce M. Spiegelman · Journal of Biological Chemistry · 1,175

PPARalpha and PPARgamma activators direct a distinct tissue‐specific transcriptional response via a PPRE in the lipoprotein lipase gene.

1996 · K. Schoonjans, J. Peinado‐Onsurbe, et al. · The EMBO Journal · 1,173

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Works count: 18,570

Citation count: 652,600