Keyword

PPARα agonist

Description: A drug or compound that activates peroxisome proliferator-activated receptor alpha, a nuclear receptor involved in lipid metabolism and other physiological processes.

Primary topic: Peroxisome Proliferator-Activated Receptors (45%)

Wikidata ID: wiki/Q10331450

OpenAlex ID: keywords/pparalpha-agonists

Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α

2003 · Jin Fu, Silvana Gaetani, et al. · Nature · 1,065

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Sorting out the roles of PPAR in energy metabolism and vascular homeostasis

2006 · P. Lefebvre · Journal of Clinical Investigation · 960

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Molecular Actions of PPARα in Lipid Metabolism and Inflammation

2018 · Nadia Bougarne, Basiel Weyers, et al. · Endocrine Reviews · 892

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ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

2011 · Guenter Haemmerle, Tarek Moustafa, et al. · Nature Medicine · 763

Triglyceride Lowering with Pemafibrate to Reduce Cardiovascular Risk

2022 · Aruna Das Pradhan, Robert J. Glynn, et al. · New England Journal of Medicine · 740

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2016 · Vivette D. D'Agati, Avry Chagnac, et al. · Nature Reviews Nephrology · 716

Therapeutic Roles of Peroxisome Proliferator–Activated Receptor Agonists

2005 · Bart Staels, Jean-Charles Fruchart · Diabetes · 645

PPARα Agonist-Induced Rodent Tumors: Modes of Action and Human Relevance

2003 · James E. Klaunig, Michael A. Babich, et al. · Critical Reviews in Toxicology · 611

Peroxisome Proliferator-activated Receptor α Activators Improve Insulin Sensitivity and Reduce Adiposity

2000 · Michèle Guerre-Millo, Philippe Gervois, et al. · Journal of Biological Chemistry · 605

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Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPARγ Agonists: A Potential Mechanism of Insulin Sensitization

2002 · Terry P. Combs, John A. Wagner, et al. · Endocrinology · 565

“New” hepatic fat activates PPARα to maintain glucose, lipid, and cholesterol homeostasis

2005 · Manu V. Chakravarthy, Zhijun Pan, et al. · Cell Metabolism · 545

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The role and regulation of the peroxisome proliferator activated receptor alpha in human liver

2017 · Sander Kersten, Rinke Stienstra · Biochimie · 395

Administration of the potent PPARα agonist, Wy-14,643, reverses nutritional fibrosis and steatohepatitis in mice

2004 · Emilia Ip, Geoff Farrell, et al. · Hepatology · 383

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Activation of PPARA-mediated autophagy reduces Alzheimer disease-like pathology and cognitive decline in a murine model

2019 · Rongcan Luo, Ling-Yan Su, et al. · Autophagy · 364

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Peroxisome Proliferator—Activated Receptor (PPAR)-αActivation Lowers Muscle Lipids and Improves Insulin Sensitivity in High Fat—Fed Rats

2001 · Ji-Ming Ye, Patrick J. Doyle, et al. · Diabetes · 343

Activation of Peroxisome Proliferator–Activated Receptor (PPAR)δ Promotes Reversal of Multiple Metabolic Abnormalities, Reduces Oxidative Stress, and Increases Fatty Acid Oxidation in Moderately Obese Men

2007 · Ulf Risérus, Dennis Sprecher, et al. · Diabetes · 326

Rapid Broad-Spectrum Analgesia through Activation of Peroxisome Proliferator-Activated Receptor-α

2006 · Jesse LoVerme, Roberto Russo, et al. · Journal of Pharmacology and Experimental Therapeutics · 317

Peroxisome Proliferator-activated Receptor α (PPARα) Induces PPARγ Coactivator 1α (PGC-1α) Gene Expression and Contributes to Thermogenic Activation of Brown Fat

2011 · Elayne Hondares, Meritxell Rosell, et al. · Journal of Biological Chemistry · 295

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Macrophage Differentiation to Foam Cells

2005 · P. Shashkin, B. Dragulev, et al. · Current Pharmaceutical Design · 295

Peroxisome Proliferator-activated Receptor α (PPARα) Agonist Treatment Reverses PPARα Dysfunction and Abnormalities in Hepatic Lipid Metabolism in Ethanol-fed Mice

2003 · Monika Fischer, Min You, et al. · Journal of Biological Chemistry · 291

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Targeting inflammation in metabolic syndrome

2015 · Francine K. Welty, Abdulhamied Alfaddagh, et al. · Translational research · 287

Molecular Pathways: Radiation-Induced Cognitive Impairment

2013 · Dana Greene-Schloesser, Elizabeth Moore, et al. · Clinical Cancer Research · 284

Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor‐21 in patients with type 2 diabetes and obesity

2008 · M. Mraz, M. Bartlova, et al. · Clinical Endocrinology · 279

Oleoylethanolamide, an endogenous PPAR-α agonist, lowers body weight and hyperlipidemia in obese rats

2005 · Jin Fu, Fariba Oveisi, et al. · Neuropharmacology · 276

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Roles of the peroxisome proliferator-activated receptors (PPARs) in the pathogenesis of nonalcoholic fatty liver disease (NAFLD)

2023 · Yuan-Ye Qiu, Jing Zhang, et al. · Pharmacological Research · 270

Works count: 2,223

Citation count: 58,670