Keyword

PRMT3

Description: Protein arginine methyltransferase 3, an enzyme that methylates proteins and is studied in molecular biology and disease research.

Primary topic: Cancer-related gene regulation (62%)

OpenAlex ID: keywords/prmt3

Crystal structure of the conserved core of protein arginine methyltransferase PRMT3

2000 · Xing Zhang, Lan Zhou, et al. · The EMBO Journal · 316

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PRMT 3, a Type I Protein Arginine N-Methyltransferase That Differs from PRMT1 in Its Oligomerization, Subcellular Localization, Substrate Specificity, and Regulation

1998 · Jie Tang, Jonathan D. Gary, et al. · Journal of Biological Chemistry · 314

A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases

2015 · Mohammad S. Eram, Yudao Shen, et al. · ACS Chemical Biology · 292

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The protein arginine methyltransferase family: an update about function, new perspectives and the physiological role in humans

2009 · S. S. Wolf · Cellular and Molecular Life Sciences · 232

PRMT3 is a ribosomal protein methyltransferase that affects the cellular levels of ribosomal subunits

2004 · François Bachand, Pamela A Silver · The EMBO Journal · 171

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New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro

2015 · Min-Jung Park, Dong-Il Kim, et al. · Cellular Signalling · 168

Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3)

2005 · Rafal SWIERCZ, Maria D. PERSON, et al. · Biochemical Journal · 160

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Ribosomal Protein rpS2 Is Hypomethylated in PRMT3-deficient Mice

2007 · Rafal Swiercz, Donghang Cheng, et al. · Journal of Biological Chemistry · 145

Unusual Sites of Arginine Methylation in Poly(A)-binding Protein II and in Vitro Methylation by Protein Arginine Methyltransferases PRMT1 and PRMT3

1999 · Jason J. Smith, Karl Peter Rücknagel, et al. · Journal of Biological Chemistry · 144

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A Potent, Selective and Cell‐Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3)

2015 · H. Ümit Kaniskan, Magdalena M. Szewczyk, et al. · Angewandte Chemie International Edition · 143

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Protein Arginine Methyltransferases: from Unicellular Eukaryotes to Humans

2007 · François Bachand · Eukaryotic Cell · 131

PRMT3 Is a Distinct Member of the Protein Arginine N-Methyltransferase Family

2000 · Adam Frankel, Steven Clarke · Journal of Biological Chemistry · 126

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DAL-1/4.1B tumor suppressor interacts with protein arginine N-methyltransferase 3 (PRMT3) and inhibits its ability to methylate substrates in vitro and in vivo

2004 · Vinita Singh, Tina Branscombe Miranda, et al. · Oncogene · 122

An Allosteric Inhibitor of Protein Arginine Methyltransferase 3

2012 · Alena Siarheyeva, Guillermo Senisterra, et al. · Structure · 101

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Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization

2018 · Lifeng Huang, Zhihao Wang, et al. · Nucleic Acids Research · 96

Expression of nitric oxide related enzymes in coronary heart disease

2006 · X. Chen, F. Niroomand, et al. · Basic Research in Cardiology · 96

PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer

2023 · Yunxing Shi, Yi Niu, et al. · Nature Communications · 93

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Arabidopsis protein arginine methyltransferase 3 is required for ribosome biogenesis by affecting precursor ribosomal RNA processing

2014 · Runlai Hang, Chunyan Liu, et al. · Proceedings of the National Academy of Sciences · 92

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Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A

2022 · Yu Lei, Ping Han, et al. · Clinical and Translational Medicine · 91

Asymmetrical methyltransferase PRMT3 regulates human mesenchymal stem cell osteogenesis via miR-3648

2019 · Zhang Min, Liu Xiaomeng, et al. · Cell Death and Disease · 75

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Exploiting an Allosteric Binding Site of PRMT3 Yields Potent and Selective Inhibitors

2013 · Feng Liu, Fengling Li, et al. · Journal of Medicinal Chemistry · 75

Are STATS Arginine-methylated?

2005 · Waraporn Komyod, Uta-Maria Bauer, et al. · Journal of Biological Chemistry · 73

PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism

2022 · Yunfei Liao, Zaili Luo, et al. · Cell Death and Disease · 72

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Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression

2018 · Ming-Chuan Hsu, Mei-Ren Pan, et al. · Cancers · 71

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Design, Synthesis and Biological Evaluation of Carboxy Analogues of Arginine Methyltransferase Inhibitor 1 (AMI‐1)

2010 · Sabrina Castellano, Ciro Milite, et al. · ChemMedChem · 67

Works count: 196

Citation count: 5,529