Keyword

PRMT5

Description: A protein arginine methyltransferase encoded by a human gene and involved in cellular processes including gene regulation.

Primary topic: Cancer-related gene regulation (55%)

Wikidata ID: wiki/Q18035368

OpenAlex ID: keywords/prmt5

MTAP deletion confers enhanced dependency on the PRMT5 arginine methyltransferase in cancer cells

2016 · Gregory V. Kryukov, Frederick H. Wilson, et al. · Science · 667

Human SWI/SNF-Associated PRMT5 Methylates Histone H3 Arginine 8 and Negatively Regulates Expression of ST7 and NM23 Tumor Suppressor Genes

2004 · Sharmistha Pal, Sheethal N. Vishwanath, et al. · Molecular and Cellular Biology · 594

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

2016 · Konstantinos J. Mavrakis, E. Robert McDonald, et al. · Science · 588

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

2015 · Elayne Chan-Penebre, Kristy G Kuplast, et al. · Nature Chemical Biology · 552

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

2009 · Quan Zhao, Gerhard Rank, et al. · Nature Structural & Molecular Biology · 537

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

2015 · Nicole Stopa, Jocelyn E. Krebs, et al. · Cellular and Molecular Life Sciences · 514

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

2016 · Katya Marjon, Michael J. Cameron, et al. · Cell Reports · 469

PDF

Blimp1 associates with Prmt5 and directs histone arginine methylation in mouse germ cells

2006 · Katia Ancelin, Ulrike C. Lange, et al. · Nature Cell Biology · 464

Arginine methylation regulates the p53 response

2008 · Martin Jansson, Stephen T. Durant, et al. · Nature Cell Biology · 463

Protein arginine methylation: from enigmatic functions to therapeutic targeting

2021 · Qin Wu, Matthieu Schapira, et al. · Nature Reviews Drug Discovery · 422

MYC regulates the core pre-mRNA splicing machinery as an essential step in lymphomagenesis

2015 · Cheryl M. Koh, Marco Bezzi, et al. · Nature · 381

Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln

2001 · Gunter Meister, Christian Eggert, et al. · Current Biology · 369

PDF

Crystal structure of the human PRMT5:MEP50 complex

2012 · Stephen Antonysamy, Zahid Bonday, et al. · Proceedings of the National Academy of Sciences · 364

PDF

PRMT5 (Janus Kinase-binding Protein 1) Catalyzes the Formation of Symmetric Dimethylarginine Residues in Proteins

2001 · Tina L. Branscombe, Adam Frankel, et al. · Journal of Biological Chemistry · 362

PDF

Prmt5 is essential for early mouse development and acts in the cytoplasm to maintain ES cell pluripotency

2010 · Wee-Wei Tee, Mercedes Pardo, et al. · Genes & Development · 357

PDF

A Proteomic Analysis of Arginine-methylated Protein Complexes

2003 · François-Michel Boisvert, Jocelyn Côté, et al. · Molecular & Cellular Proteomics · 356

PDF

Symmetric dimethylation of H3R2 is a newly identified histone mark that supports euchromatin maintenance

2012 · Valentina Migliori, Julius Müller, et al. · Nature Structural & Molecular Biology · 347

Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss

2019 · Andrew Fedoriw, Satyajit R. Rajapurkar, et al. · Cancer Cell · 344

PDF

Arginine methylation at a glance

2007 · Mark T. Bedford · Journal of Cell Science · 341

PDF

MBD2/NuRD and MBD3/NuRD, Two Distinct Complexes with Different Biochemical and Functional Properties

2006 · Xavier Le Guezennec, Michiel Vermeulen, et al. · Molecular and Cellular Biology · 340

Proteome-wide analysis of arginine monomethylation reveals widespread occurrence in human cells

2016 · Sara C. Larsen, Kathrine B. Sylvestersen, et al. · Science Signaling · 322

Regulation of constitutive and alternative splicing by PRMT5 reveals a role for Mdm4 pre-mRNA in sensing defects in the spliceosomal machinery

2013 · Marco Bezzi, Shun Xie Teo, et al. · Genes & Development · 303

PDF

Low levels of miR‐92b/96 induce PRMT5 translation and H3R8/H4R3 methylation in mantle cell lymphoma

2007 · Sharmistha Pal, Robert A Baiocchi, et al. · The EMBO Journal · 282

PDF

Versatility of PRMT5-induced methylation in growth control and development

2011 · Vrajesh Karkhanis, Yu-Jie Hu, et al. · Trends in Biochemical Sciences · 280

Protein arginine methyltransferases: Evolution and assessment of their pharmacological and therapeutic potential

2006 · Christopher D. Krause, Zhi-Hong Yang, et al. · Pharmacology & Therapeutics · 276

Works count: 2,528

Citation count: 53,230