Keyword

PROTACs

Description: Proteolysis-targeting chimeras are bifunctional molecules that recruit target proteins to cellular degradation machinery, enabling targeted protein degradation in biomedical research and drug development.

Primary topic: Protein Degradation and Inhibitors (69%)

Wikidata ID: wiki/Q25324636

OpenAlex ID: keywords/protacs

PROTAC targeted protein degraders: the past is prologue

2022 · Miklós Békés, David R. Langley, et al. · Nature Reviews Drug Discovery · 3,249

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Protacs: Chimeric molecules that target proteins to the Skp1–Cullin–F box complex for ubiquitination and degradation

2001 · Kathleen M. Sakamoto, Kyung B. Kim, et al. · Proceedings of the National Academy of Sciences · 2,521

Induced protein degradation: an emerging drug discovery paradigm

2016 · Ashton C. Lai, Craig M. Crews · Nature Reviews Drug Discovery · 1,425

Catalytic in vivo protein knockdown by small-molecule PROTACs

2015 · Daniel P Bondeson, Alina Mares, et al. · Nature Chemical Biology · 1,324

Structural basis of PROTAC cooperative recognition for selective protein degradation

2017 · Morgan S Gadd, Andrea Testa, et al. · Nature Chemical Biology · 1,191

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Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies

2024 · Jifa Zhang, Yinglu Zhang, et al. · Signal Transduction and Targeted Therapy · 1,152

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Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4

2015 · Jing Lu, Yimin Qian, et al. · Chemistry & Biology · 1,115

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Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

2020 · George M. Burslem, Craig M. Crews · Cell · 1,050

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Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4

2015 · Michael Zengerle, Kwok-Ho Chan, et al. · ACS Chemical Biology · 1,031

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Targeted protein degradation: mechanisms, strategies and application

2022 · Lin Zhao, Jia Zhao, et al. · Signal Transduction and Targeted Therapy · 957

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Targeted protein degradation: expanding the toolbox

2019 · Matthieu Schapira, Matthew F. Calabrese, et al. · Nature Reviews Drug Discovery · 936

Targeting transcription factors in cancer — from undruggable to reality

2019 · John H. Bushweller · Nature reviews. Cancer · 915

Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

2017 · Daniel P. Bondeson, Blake E. Smith, et al. · Cell chemical biology · 888

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PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer

2016 · Kanak Raina, Jing Lu, et al. · Proceedings of the National Academy of Sciences · 829

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PROTACs: past, present and future

2022 · Ke Li, Craig M. Crews · Chemical Society Reviews · 807

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PROteolysis TArgeting Chimeras (PROTACs) — Past, present and future

2019 · Mariell Pettersson, Craig M. Crews · Drug Discovery Today Technologies · 804

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A selective BCL-XL PROTAC degrader achieves safe and potent antitumor activity

2019 · Sajid Khan, Xuan Zhang, et al. · Nature Medicine · 671

The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study

2017 · George M. Burslem, Blake E. Smith, et al. · Cell chemical biology · 665

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AUTACs: Cargo-Specific Degraders Using Selective Autophagy

2019 · Daiki Takahashi, Jun Moriyama, et al. · Molecular Cell · 655

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Small‐Molecule PROTACS: New Approaches to Protein Degradation

2016 · Momar Toure, Craig M. Crews · Angewandte Chemie International Edition · 648

Advancing targeted protein degradation for cancer therapy

2021 · Brandon Dale, Meng Cheng, et al. · Nature reviews. Cancer · 634

Protein degraders enter the clinic — a new approach to cancer therapy

2023 · Deborah Chirnomas, Keith R. Hornberger, et al. · Nature Reviews Clinical Oncology · 623

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PROTACs: great opportunities for academia and industry

2019 · Xiuyun Sun, Hongying Gao, et al. · Signal Transduction and Targeted Therapy · 621

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Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics

2008 · Ashley R. Schneekloth, Mathieu Pucheault, et al. · Bioorganic & Medicinal Chemistry Letters · 616

Modular PROTAC Design for the Degradation of Oncogenic BCR‐ABL

2015 · Ashton C. Lai, Momar Toure, et al. · Angewandte Chemie International Edition · 609

Works count: 6,442

Citation count: 149,800