Keyword

PrPSc

Description: The disease-associated, misfolded form of the prion protein that can induce misfolding of its normal cellular counterpart.

Primary topic: Prion Diseases and Protein Misfolding (98%)

Wikidata ID: wiki/Q47051

OpenAlex ID: keywords/prpsc

Prions

1998 · Stanley B. Prusiner · Proceedings of the National Academy of Sciences · 5,368

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

1993 · K M Pan, M Baldwin, et al. · Proceedings of the National Academy of Sciences · 2,278

Molecular analysis of prion strain variation and the aetiology of 'new variant' CJD

1996 · John Collinge, Katie C. L. Sidle, et al. · Nature · 1,737

Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding

2001 · Gabriela P. Saborio, Bruno Permanne, et al. · Nature · 1,310

Eight prion strains have PrPSc molecules with different conformations

1998 · Jiri Safar, Holger Wille, et al. · Nature Medicine · 1,245

Scrapie prion protein contains a phosphatidylinositol glycolipid

1987 · N STAHL · Cell · 1,112

Cell-free formation of protease-resistant prion protein

1994 · David A. Kocisko, Jon H. Come, et al. · Nature · 883

Prion protein (PrP) with amino‐proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

1996 · M. Fischer, T. Rülicke, et al. · The EMBO Journal · 877

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Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

1990 · Stanley B. Prusiner, Michael Scott, et al. · Cell · 871

Normal host prion protein necessary for scrapie-induced neurotoxicity

1996 · Sebastian Brandner, Stefan Isenmann, et al. · Nature · 810

Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis

2003 · Giovanna Mallucci, Andrew Dickinson, et al. · Science · 770

A Transmembrane Form of the Prion Protein in Neurodegenerative Disease

1998 · Ramanujan S. Hegde, James A. Mastrianni, et al. · Science · 729

Sulfated Glycans Stimulate Endocytosis of the Cellular Isoform of the Prion Protein, PrPC, in Cultured Cells

1995 · Show-Ling Shyng, Sylvain Lehmann, et al. · Journal of Biological Chemistry · 704

Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay

2001 · JDF Wadsworth, S Joiner, et al. · The Lancet · 693

Formation of native prions from minimal components in vitro

2007 · Nathan R. Deleault, Brent T. Harris, et al. · Proceedings of the National Academy of Sciences · 631

Separation and properties of cellular and scrapie prion proteins.

1986 · R K Meyer, M P McKinley, et al. · Proceedings of the National Academy of Sciences · 623

Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing

1993 · Neil Stahl, Michael A. Baldwin, et al. · Biochemistry · 583

Prion (PrPSc)-specific epitope defined by a monoclonal antibody

1997 · C. Korth, B. Stierli, et al. · Nature · 567

Evidence for assembly of prions with left-handed β-helices into trimers

2004 · Cédric Govaerts, Holger Wille, et al. · Proceedings of the National Academy of Sciences · 539

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Subcellular colocalization of the cellular and scrapie prion proteins in caveolae-like membranous domains

1996 · Martin Vey, Susanne Pilkuhn, et al. · Proceedings of the National Academy of Sciences · 525

Non-genetic propagation of strain-specific properties of scrapie prion protein

1995 · Richard A. Bessen, David A. Kocisko, et al. · Nature · 525

Crystal structure of the human prion protein reveals a mechanism for oligomerization.

2001 · Karen J. Knaus, Manuel Morillas, et al. · Nature Structural Biology · 518

RNA molecules stimulate prion protein conversion

2003 · Nathan R. Deleault, Ralf W. Lucassen, et al. · Nature · 505

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

1990 · D R Borchelt, M Scott, et al. · The Journal of Cell Biology · 504

Evidence for synthesis of scrapie prion proteins in the endocytic pathway.

1992 · D.R. Borchelt, A Taraboulos, et al. · Journal of Biological Chemistry · 498

Works count: 2,445

Citation count: 100,900