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Keyword

PTPN2

Description: PTPN2 is a human protein-coding gene that encodes protein tyrosine phosphatase non-receptor type 2, an enzyme involved in cellular signaling.
Wikidata ID: wiki/Q18030926
OpenAlex ID: keywords/ptpn2
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
2007 · Miles Parkes, Jeffrey C Barrett, et al. · Nature Genetics · 1,155
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In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target
2017 · Robert T. Manguso, Hans W. Pope, et al. · Nature · 1,140
A ChIP-seq defined genome-wide map of vitamin D receptor binding: Associations with disease and evolution
2010 · Sreeram V. Ramagopalan, Andreas Heger, et al. · Genome Research · 873
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Shared and Distinct Genetic Variants in Type 1 Diabetes and Celiac Disease
2008 · Deborah J. Smyth, Vincent Plagnol, et al. · New England Journal of Medicine · 742
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Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels
2011 · Abbas Dehghan, Josée Dupuis, et al. · Circulation · 511
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Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy
2019 · Jun Wei, Lingyun Long, et al. · Nature · 449
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells
2020 · Keith A. Lawson, Cristovão M. Sousa, et al. · Nature · 441
Dense genotyping of immune-related disease regions identifies 14 new susceptibility loci for juvenile idiopathic arthritis
2013 · Boston Children's JIA Registry, Anne Hinks, et al. · Nature Genetics · 404
Replication of signals from recent studies of Crohn's disease identifies previously unknown disease loci for ulcerative colitis
2008 · Andre Franke, Tobias Balschun, et al. · Nature Genetics · 352
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population
2012 · Yukinori Okada, Chikashi Terao, et al. · Nature Genetics · 331
Viral infections in type 1 diabetes mellitus — why the β cells?
2016 · Anne Op de Beeck, Decio L. Eizirik · Nature Reviews Endocrinology · 290
PTPN2 regulates the generation of exhausted CD8+ T cell subpopulations and restrains tumor immunity
2019 · Martin W. LaFleur, Thao H. Nguyen, et al. · Nature Immunology · 246
Whole-genome sequencing of a sporadic primary immunodeficiency cohort
2020 · James E. D. Thaventhiran, Hana Lango Allen, et al. · Nature · 240
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Schistosomiasis — Assessing Progress toward the 2020 and 2025 Global Goals
2019 · Arminder K. Deol, Fiona M. Fleming, et al. · New England Journal of Medicine · 226
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A Meta-Analysis of Genome-Wide Association Scans Identifies IL18RAP, PTPN2, TAGAP, and PUS10 As Shared Risk Loci for Crohn's Disease and Celiac Disease
2011 · Eleonora A. M. Festen, Philippe Goyette, et al. · PLoS Genetics · 224
T cell protein tyrosine phosphatase attenuates T cell signaling to maintain tolerance in mice
2011 · Florian Wiede, Benjamin J. Shields, et al. · Journal of Clinical Investigation · 222
Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia
2010 · Maria Kleppe, Idoya Lahortiga, et al. · Nature Genetics · 199
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity
2023 · Christina K. Baumgartner, Hakimeh Ebrahimi-Nik, et al. · Nature · 190
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Protein Tyrosine Phosphatases as Potential Regulators of STAT3 Signaling
2018 · Mihwa Kim, Liza D. Morales, et al. · International Journal of Molecular Sciences · 176
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PTPN2, a Candidate Gene for Type 1 Diabetes, Modulates Interferon-γ–Induced Pancreatic β-Cell Apoptosis
2009 · Fabrice Moore, Maikel L. Colli, et al. · Diabetes · 167
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Reactive oxygen species-responsive miR-210 regulates proliferation and migration of adipose-derived stem cells via PTPN2
2013 · J H Kim, S G Park, et al. · Cell Death and Disease · 152
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PTPN2 Regulates Interactions Between Macrophages and Intestinal Epithelial Cells to Promote Intestinal Barrier Function
2020 · Marianne R. Spalinger, Anica Sayoc-Becerra, et al. · Gastroenterology · 147
Long‐term outcome in dogs with chronic enteropathies: 203 cases
2016 · K. Allenspach, C. Culverwell, et al. · Veterinary Record · 143
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PTPN2 phosphatase deletion in T cells promotes anti‐tumour immunity and CAR T‐cell efficacy in solid tumours
2019 · Florian Wiede, Kun-Hui Lu, et al. · The EMBO Journal · 142
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An autoimmune-associated variant in PTPN2 reveals an impairment of IL-2R signaling in CD4+ T cells
2010 · S A Long, K Cerosaletti, et al. · Genes and Immunity · 142
Works count: 1,050
Citation count: 19,810
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