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Keyword

Raf-1

Description: RAF1, also called CRAF, is a protein kinase in the RAS–MAPK signaling pathway that regulates cell growth and is studied in cancer biology.
OpenAlex ID: keywords/raf-1
Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF
2004 · Paul T.C Wan, Mathew J Garnett, et al. · Cell · 2,809
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Mammalian Ras interacts directly with the serine/threonine kinase raf
1993 · Anne B. Vojtek, Stanley M. Hollenberg, et al. · Cell · 1,941
RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF
2010 · Poulikos I. Poulikakos, Chao Zhang, et al. · Nature · 1,816
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Kinase-Dead BRAF and Oncogenic RAS Cooperate to Drive Tumor Progression through CRAF
2010 · Sonja J. Heidorn, Carla Milagre, et al. · Cell · 1,466
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Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine
1996 · Anthony J Muslin, J.William Tanner, et al. · Cell · 1,381
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Raf-1 activates MAP kinase-kinase
1992 · John M. Kyriakis, Harald App, et al. · Nature · 1,283
Protein kinase Cα activates RAF-1 by direct phosphorylation
1993 · Walter Kolch, Gisela Heidecker, et al. · Nature · 1,278
The RAF proteins take centre stage
2004 · Claudia Wellbrock, Maria Karasarides, et al. · Nature Reviews Molecular Cell Biology · 1,231
Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway
1996 · Josée N. Lavoie, Gilles L'Allemain, et al. · Journal of Biological Chemistry · 1,211
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Differential Activation of ERK and JNK Mitogen-Activated Protein Kinases by Raf-1 and MEKK
1994 · Audrey Minden, Anning Lin, et al. · Science · 1,069
cAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway
1997 · Mark R Vossler, Hong Yao, et al. · Cell · 1,046
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EGFR-Mediated Reactivation of MAPK Signaling Contributes to Insensitivity of BRAF -Mutant Colorectal Cancers to RAF Inhibition with Vemurafenib
2012 · Ryan B. Corcoran, Hiromichi Ebi, et al. · Cancer Discovery · 1,021
Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase
1993 · Shonna A. Moodie, Berthe M. Willumsen, et al. · Science · 968
Inhibition by cAMP of Ras-Dependent Activation of Raf
1993 · Simon J. Cook, Frank McCormick · Science · 922
ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK
1992 · Kenneth W. Wood, Charlyn Sarnecki, et al. · Cell · 903
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
1999 · Kam Yeung, Thomas Seitz, et al. · Nature · 895
Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1
1993 · Xian-Feng Zhang, Jeffrey Settleman, et al. · Nature · 858
The mammalian ultraviolet response is triggered by activation of src tyrosine kinases
1992 · Yoram Devary, Roberta A. Gottlieb, et al. · Cell · 852
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
2013 · Jinghui Zhang, Gang Wu, et al. · Nature Genetics · 835
Senescence of human fibroblasts induced by oncogenic Raf
1998 · Jiyue Zhu, Douglas Woods, et al. · Genes & Development · 826
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β-Arrestin–Dependent Endocytosis of Proteinase-Activated Receptor 2 Is Required for Intracellular Targeting of Activated Erk1/2
2000 · K.A. DeFea, J. Zalevsky, et al. · The Journal of Cell Biology · 822
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Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria
1996 · Hong-Gang Wang, Ulf R Rapp, et al. · Cell · 766
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Identification of a Dual Specificity Kinase That Activates the Jun Kinases and p38-Mpk2
1995 · Anning Lin, Audrey Minden, et al. · Science · 764
Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes
1998 · Dorothee C. Schönwasser, Richard M. Marais, et al. · Molecular and Cellular Biology · 760
Inhibition of Histone Deacetylase 6 Acetylates and Disrupts the Chaperone Function of Heat Shock Protein 90
2005 · Purva Bali, Michael Pranpat, et al. · Journal of Biological Chemistry · 754
Works count: 5,888
Citation count: 277,200
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