Keyword

RANKL

Description: A protein that binds the RANK receptor and promotes osteoclast formation and activity, making it important in bone remodeling and immune biology.

Primary topic: Bone Metabolism and Diseases (50%)

Related topic: Bone Metabolism and Diseases (50%)

OpenAlex ID: keywords/rankl

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 · Hisataka Yasuda, Nobuyuki Shima, et al. · Proceedings of the National Academy of Sciences · 4,228

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 · Young-Yun Kong, Hiroki Yoshida, et al. · Nature · 3,350

Osteoporosis: now and the future

2011 · Tilman D Rachner, Sundeep Khosla, et al. · The Lancet · 2,676

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

1999 · Tatsuo Suda, Naoyuki Takahashi, et al. · Endocrine Reviews · 2,336

Romosozumab Treatment in Postmenopausal Women with Osteoporosis

2016 · Felicia Cosman, Daria B. Crittenden, et al. · New England Journal of Medicine · 1,789

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Evidence for osteocyte regulation of bone homeostasis through RANKL expression

2011 · Tomoki Nakashima, Mikihito Hayashi, et al. · Nature Medicine · 1,770

Minireview: The OPG/RANKL/RANK System

2001 · S. Khosla · Endocrinology · 1,512

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The molecular understanding of osteoclast differentiation

2006 · Masataka Asagiri, Hiroshi Takayanagi · Bone · 1,361

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

2000 · Hiroshi Takayanagi, Kouetsu Ogasawara, et al. · Nature · 1,357

Leptin regulation of bone resorption by the sympathetic nervous system and CART

2005 · Florent Elefteriou, Jong Deok Ahn, et al. · Nature · 1,311

Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction

2000 · Kanichiro Kobayashi, Naoyuki Takahashi, et al. · The Journal of Experimental Medicine · 1,304

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Matrix-embedded cells control osteoclast formation

2011 · Jinhu Xiong, Melda Onal, et al. · Nature Medicine · 1,300

Pathogenic conversion of Foxp3+ T cells into TH17 cells in autoimmune arthritis

2013 · Noriko Komatsu, Kazuo Okamoto, et al. · Nature Medicine · 1,144

Clinical Implications of the Osteoprotegerin/RANKL/RANK System for Bone and Vascular Diseases

2004 · Lorenz C. Hofbauer · JAMA · 988

Biology of RANK, RANKL, and osteoprotegerin

2007 · Brendan F Boyce, Lianping Xing · Arthritis Research & Therapy · 957

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A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation

2005 · Na Kyung Lee, Young Geum Choi, et al. · Blood · 957

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IL-6, RANKL, TNF-alpha/IL-1: interrelations in bone resorption pathophysiology

2004 · Kwan Tat Steeve, Padrines Marc, et al. · Cytokine & Growth Factor Reviews · 952

Calcific aortic stenosis

2016 · Brian R. Lindman, Marie-Annick Clavel, et al. · Nature Reviews Disease Primers · 947

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

2012 · Georg Schett, Ellen Gravallese · Nature Reviews Rheumatology · 944

Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis

2004 · Takako Koga, Masanori Inui, et al. · Nature · 828

Receptor Activator of Nuclear Factor κB Ligand and Osteoprotegerin Regulation of Bone Remodeling in Health and Disease

2007 · Ann E. Kearns, Sundeep Khosla, et al. · Endocrine Reviews · 821

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RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution

2002 · Lars E. Theill, William J. Boyle, et al. · Annual Review of Immunology · 820

Decreased Bacterial Diversity Characterizes the Altered Gut Microbiota in Patients With Psoriatic Arthritis, Resembling Dysbiosis in Inflammatory Bowel Disease

2014 · Jose U. Scher, Carles Ubeda, et al. · Arthritis & Rheumatology · 815

Regulation of cancer cell migration and bone metastasis by RANKL

2006 · D. Holstead Jones, Tomoki Nakashima, et al. · Nature · 796

IL-1 mediates TNF-induced osteoclastogenesis

2005 · Shi Wei, Hideki Kitaura, et al. · Journal of Clinical Investigation · 796

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Works count: 19,840

Citation count: 540,400