Keyword

Ras activation

Description: The conversion of Ras proteins into their active, GTP-bound form, enabling them to transmit signals in cellular pathways.

Primary topic: Protein Kinase Regulation and GTPase Signaling (48%)

OpenAlex ID: keywords/ras-activation

RAS Proteins and Their Regulators in Human Disease

2017 · Dhirendra K. Simanshu, Dwight V. Nissley, et al. · Cell · 1,917

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Phosphorylation of c-jun mediated by MAP kinases

1991 · Bernd J. Pulverer, John M. Kyriakis, et al. · Nature · 1,468

RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)

2011 · Poulikos I. Poulikakos, Yogindra Persaud, et al. · Nature · 1,451

The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

1993 · Maria Rozakis-Adcock, Ross Fernley, et al. · Nature · 1,009

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 · Shonna A. Moodie, Berthe M. Willumsen, et al. · Science · 968

Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice

2000 · Eric C. Holland, Joseph Celestino, et al. · Nature Genetics · 905

An Acylation Cycle Regulates Localization and Activity of Palmitoylated Ras Isoforms

2005 · Oliver Rocks, Anna Peyker, et al. · Science · 839

The structural basis of the activation of Ras by Sos

1998 · P. Ann Boriack-Sjodin, S. Mariana Margarit, et al. · Nature · 792

Mechanisms of Aflatoxin Carcinogenesis

1994 · D L Eaton, E P Gallagher · The Annual Review of Pharmacology and Toxicology · 792

PI 3-kinase, Akt and cell survival

2004 · Julian Downward · Seminars in Cell and Developmental Biology · 784

TGF- β signaling in cancer – a double-edged sword

2001 · Rosemary J Akhurst, Rik Derynck · Trends in Cell Biology · 755

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 · Julius O. Ebinu, Drell A. Bottorff, et al. · Science · 689

Regulation of tyrosine kinase cascades by G-protein-coupled receptors

1999 · Louis M Luttrell, Yehia Daaka, et al. · Current Opinion in Cell Biology · 682

Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML

2020 · C. D. DiNardo, I. S. Tiong, et al. · Blood · 680

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Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

1993 · Mindaugas Valius, Andrius Kazlauskas · Cell · 647

Direct small-molecule inhibitors of KRAS: from structural insights to mechanism-based design

2016 · Jonathan M. L. Ostrem, Kevan M. Shokat · Nature Reviews Drug Discovery · 633

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

2012 · Till Maurer, Lindsay S. Garrenton, et al. · Proceedings of the National Academy of Sciences · 614

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Germline gain-of-function mutations in SOS1 cause Noonan syndrome

2006 · Amy E Roberts, Toshiyuki Araki, et al. · Nature Genetics · 603

Crystal Structure and Functional Analysis of Ras Binding to Its Effector Phosphoinositide 3-Kinase γ

2000 · Michael E. Pacold, Sabine Suire, et al. · Cell · 603

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Ras signalling on the endoplasmic reticulum and the Golgi

2002 · Vi K. Chiu, Trever Bivona, et al. · Nature Cell Biology · 600

Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

1993 · Nicholas W. Gale, Susan Kaplan, et al. · Nature · 563

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS

2017 · Zhan Yao, Rona Yaeger, et al. · Nature · 561

RAF-MEK-ERK pathway in cancer evolution and treatment

2021 · Rahim Ullah, Qing Yin, et al. · Seminars in Cancer Biology · 544

A Drosophila SH2-SH3 adaptor protein implicated in coupling the sevenless tyrosine kinase to an activator of Ras guanine nucleotide exchange, Sos

1993 · J Olivier · Cell · 537

How receptors turn Ras on

1993 · Frank McCormick · Nature · 524

Works count: 2,080

Citation count: 109,500