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Keyword

RAS mutations

Description: Genetic alterations in RAS genes that can affect Ras protein function and contribute to cancer development or progression.
OpenAlex ID: keywords/ras-mutations
Genetic Alterations during Colorectal-Tumor Development
1988 · Bert Vogelstein, Eric R. Fearon, et al. · New England Journal of Medicine · 6,731
Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
2009 · David A. Barbie, Pablo Tamayo, et al. · Nature · 3,898
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Targeting RAS signalling pathways in cancer therapy
2003 · Julian Downward · Nature reviews. Cancer · 3,257
Genomic Classification of Cutaneous Melanoma
2015 · Rehan Akbani, Kadir C. Akdemir, et al. · Cell · 3,142
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Broadening horizons: the role of ferroptosis in cancer
2021 · Xin Chen, Rui Kang, et al. · Nature Reviews Clinical Oncology · 2,900
Panitumumab–FOLFOX4 Treatment and RAS Mutations in Colorectal Cancer
2013 · Jean-Yves Douillard, Kelly S. Oliner, et al. · New England Journal of Medicine · 2,262
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A Comprehensive Survey of Ras Mutations in Cancer
2012 · Ian A. Prior, Paul D. Lewis, et al. · Cancer Research · 2,043
Oncogenic pathway signatures in human cancers as a guide to targeted therapies
2005 · Andrea H. Bild, Guang Yao, et al. · Nature · 2,032
RAS Proteins and Their Regulators in Human Disease
2017 · Dhirendra K. Simanshu, Dwight V. Nissley, et al. · Cell · 1,910
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Prevalence of ras gene mutations in human colorectal cancers
1987 · Johannes L. Bos, Eric R. Fearon, et al. · Nature · 1,860
Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial
2014 · Marcia S Brose, Christopher M Nutting, et al. · The Lancet · 1,663
High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma.
2003 · Edna T Kimura, Marina N Nikiforova, et al. · PubMed · 1,522
PI3K/AKT/mTOR Pathway in Angiogenesis
2011 · Jayashree Karar, Amit Maity · Frontiers in Molecular Neuroscience · 1,462
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BRAF mutation predicts sensitivity to MEK inhibition
2005 · David B. Solit, Levi A. Garraway, et al. · Nature · 1,328
Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers
2016 · Iñigo Landa, Tihana Ibrahimpasic, et al. · Journal of Clinical Investigation · 1,286
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Overview of the 2022 WHO Classification of Thyroid Neoplasms
2022 · Zubair W. Baloch, Sylvia L. Asa, et al. · Endocrine Pathology · 1,161
The Frequency of Ras Mutations in Cancer
2020 · Ian A. Prior, Fiona E. Hood, et al. · Cancer Research · 1,112
BRAF and RAS mutations in human lung cancer and melanoma.
2002 · Marcia S Brose, Patricia Volpe, et al. · PubMed · 1,053
Role of tissue stroma in cancer cell invasion
2003 · Olivier De Wever, Marc Mareel · The Journal of Pathology · 1,043
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RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
2012 · Fei Su, Amaya Viros, et al. · New England Journal of Medicine · 1,038
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Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy
2012 · Libero Santarpia, Scott M Lippman, et al. · Expert Opinion on Therapeutic Targets · 1,028
Molecular genetics and diagnosis of thyroid cancer
2011 · Yuri E. Nikiforov, Marina N. Nikiforova · Nature Reviews Endocrinology · 1,012
Acquired Resistance and Clonal Evolution in Melanoma during BRAF Inhibitor Therapy
2013 · Hubing Shi, Willy Hugo, et al. · Cancer Discovery · 978
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UV-induced skin damage
2003 · M. Ichihashi, M. Ueda, et al. · Toxicology · 970
RAS isoforms and mutations in cancer at a glance
2016 · G. Aaron Hobbs, Channing J. Der, et al. · Journal of Cell Science · 959
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Works count: 7,328
Citation count: 218,500
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