Keyword

replication stress

Description: Cellular stress caused by impediments or disruptions to DNA replication, which can threaten genome stability and contribute to disease processes.

Primary topic: DNA Repair Mechanisms (45%)

Related topic: DNA Repair Mechanisms (45%)

Wikidata ID: wiki/Q28209127

OpenAlex ID: keywords/replication-stress

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

2003 · Lee Zou, Stephen J. Elledge · Science · 2,693

Causes and consequences of replication stress

2013 · Michelle K. Zeman, Karlene A. Cimprich · Nature Cell Biology · 2,068

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

2005 · Vassilis G. Gorgoulis, Leandros-Vassilios F. Vassiliou, et al. · Nature · 2,008

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

2006 · Jirina Bartkova, Nousin Rezaei, et al. · Nature · 1,986

DNA Damage Sensing by the ATM and ATR Kinases

2013 · A. Marechal, L. Zou · Cold Spring Harbor Perspectives in Biology · 1,509

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Control of cell cycle transcription during G1 and S phases

2013 · Cosetta Bertoli, Jan M. Skotheim, et al. · Nature Reviews Molecular Cell Biology · 1,504

Linkage of ATM to Cell Cycle Regulation by the Chk2 Protein Kinase

1998 · S. Matsuoka · Science · 1,322

Homologous recombination in DNA repair and DNA damage tolerance

2008 · Xuan Li, Wolf-Dietrich Heyer · Cell Research · 1,202

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Replication stress and cancer

2015 · Hélène Gaillard, Tatiana García-Muse, et al. · Nature reviews. Cancer · 1,091

ATR and ATRIP: Partners in Checkpoint Signaling

2001 · David Cortez, Saritha Guntuku, et al. · Science · 985

ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA

2013 · Luis Ignacio Toledo, Matthias Altmeyer, et al. · Cell · 909

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Choreography of the DNA Damage Response

2004 · Michael Lisby, Jacqueline H. Barlow, et al. · Cell · 890

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Replication stress links structural and numerical cancer chromosomal instability

2013 · Rebecca A. Burrell, Sarah E. McClelland, et al. · Nature · 878

Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development

2011 · Assaf C. Bester, Maayan Roniger, et al. · Cell · 854

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The essential kinase ATR: ensuring faithful duplication of a challenging genome

2017 · Joshua C. Saldivar, David Cortez, et al. · Nature Reviews Molecular Cell Biology · 841

DNA Replication Stress as a Hallmark of Cancer

2015 · Morgane Macheret, Thanos D. Halazonetis · Annual Review of Pathology Mechanisms of Disease · 825

R loops: new modulators of genome dynamics and function

2015 · José M. Santos-Pereira, Andrés Aguilera · Nature Reviews Genetics · 775

Chromosome Fragile Sites

2007 · Sandra G. Durkin, Thomas W. Glover · Annual Review of Genetics · 713

R Loops: From Physiological to Pathological Roles

2019 · Tatiana García-Muse, Andrés Aguilera · Cell · 699

PARP and PARG inhibitors in cancer treatment

2020 · Dea Slade · Genes & Development · 669

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53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress

2011 · Claudia Lukas, Velibor Savic, et al. · Nature Cell Biology · 668

Transcription-Replication Conflict Orientation Modulates R-Loop Levels and Activates Distinct DNA Damage Responses

2017 · Stephan Hamperl, Michael J. Bocek, et al. · Cell · 652

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Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

2014 · Johanna Flach, Sietske T. Bakker, et al. · Nature · 650

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ATM and ATR as therapeutic targets in cancer

2014 · Anika Maria Weber, Anderson Joseph Ryan · Pharmacology & Therapeutics · 639

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Replication stress induces sister-chromatid bridging at fragile site loci in mitosis

2009 · Kok Lung Chan, Timea Palmai-Pallag, et al. · Nature Cell Biology · 612

Works count: 7,920

Citation count: 201,300