Keyword

Rheb

Description: A small GTP-binding protein encoded by the RHEB gene that activates the mTOR signaling pathway and is studied in cell biology and cancer research.

Primary topic: PI3K/AKT/mTOR signaling in cancer (40%)

Wikidata ID: wiki/Q18031127

OpenAlex ID: keywords/rheb

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

2008 · Yasemin Sancak, Timothy R. Peterson, et al. · Science · 2,766

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

2010 · Yasemin Sancak, Liron Bar-Peled, et al. · Cell · 2,463

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Growing roles for the mTOR pathway

2005 · Dos D Sarbassov, Siraj M Ali, et al. · Current Opinion in Cell Biology · 1,563

TSC2 Integrates Wnt and Energy Signals via a Coordinated Phosphorylation by AMPK and GSK3 to Regulate Cell Growth

2006 · Ken Inoki, Hongjiao Ouyang, et al. · Cell · 1,378

Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression

2004 · Diane C Fingar, John Blenis · Oncogene · 1,249

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

2008 · Jingxiang Huang, Brendan D. Manning · Biochemical Journal · 1,235

PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase

2007 · Yasemin Sancak, Carson C. Thoreen, et al. · Molecular Cell · 1,235

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Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

2003 · Andrew R Tee, Brendan D Manning, et al. · Current Biology · 1,211

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The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

2011 · Greg M Delgoffe, Kristen N Pollizzi, et al. · Nature Immunology · 1,111

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Insulin Activation of Rheb, a Mediator of mTOR/S6K/4E-BP Signaling, Is Inhibited by TSC1 and 2

2003 · Attila Garami, Fried J.T Zwartkruis, et al. · Molecular Cell · 1,043

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Rheb Binds and Regulates the mTOR Kinase

2005 · Xiaomeng Long, Yenshou Lin, et al. · Current Biology · 1,005

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Role and Regulation of Starvation-Induced Autophagy in the Drosophila Fat Body

2004 · Ryan C. Scott, Oren Schuldiner, et al. · Developmental Cell · 963

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Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

2003 · Yong Zhang, Xinsheng Gao, et al. · Nature Cell Biology · 924

Regulation of mTORC1 by PI3K signaling

2015 · Christian C. Dibble, Lewis C. Cantley · Trends in Cell Biology · 837

Metabolism. Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

2015 · Shuyu Wang, Zhi-Yang Tsun, et al. · PubMed · 824

E2F1 Regulates Cellular Growth by mTORC1 Signaling

2011 · Sebastian Real, Nathalie Meo-Evoli, et al. · PLoS ONE · 814

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Inappropriate Activation of the TSC/Rheb/mTOR/S6K Cassette Induces IRS1/2 Depletion, Insulin Resistance, and Cell Survival Deficiencies

2004 · O.Jameel Shah, Zhiyong Wang, et al. · Current Biology · 799

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MicroRNAs Play an Essential Role in the Development of Cardiac Hypertrophy

2007 · Danish Sayed, Chull Hong, et al. · Circulation Research · 776

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Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

2014 · Suchithra Menon, Christian C. Dibble, et al. · Cell · 772

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A complex interplay between Akt, TSC2 and the two mTOR complexes

2009 · Jingxiang Huang, Brendan D. Manning · Biochemical Society Transactions · 722

Rheb promotes cell growth as a component of the insulin/TOR signalling network

2003 · Leslie J. Saucedo, Xinsheng Gao, et al. · Nature Cell Biology · 658

Signaling Pathways and Molecular Mechanisms through which Branched-Chain Amino Acids Mediate Translational Control of Protein Synthesis

2006 · Scot R Kimball, Leonard S Jefferson · Journal of Nutrition · 634

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Hypoxia-Induced Energy Stress Regulates mRNA Translation and Cell Growth

2006 · Liping Liu, Timothy P. Cash, et al. · Molecular Cell · 605

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Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

2017 · Haijuan Yang, Xiaolu Jiang, et al. · Nature · 542

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Rheb is an essential regulator of S6K in controlling cell growth in Drosophila

2003 · Hugo Stocker, Thomas Radimerski, et al. · Nature Cell Biology · 530

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Works count: 1,449

Citation count: 73,230