Keyword

Rictor

Description: A protein encoded by the RICTOR gene that forms a defining component of the mTOR complex 2 signaling pathway.

Primary topic: PI3K/AKT/mTOR signaling in cancer (37%)

Wikidata ID: wiki/Q18053691

OpenAlex ID: keywords/rictor

Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

2005 · Dos D. Sarbassov, David A. Guertin, et al. · Science · 6,209

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

2004 · Dos D. Sarbassov, Siraj M Ali, et al. · Current Biology · 2,672

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Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB

2006 · Dos D. Sarbassov, Siraj M. Ali, et al. · Molecular Cell · 2,656

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Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

2006 · David A. Guertin, Deanna M. Stevens, et al. · Developmental Cell · 1,415

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

2008 · Juan M. García-Martínez, Dario R. Alessi · Biochemical Journal · 905

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Targeting mTOR for cancer therapy

2019 · Hui Hua, Qingbin Kong, et al. · Journal of Hematology & Oncology · 900

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

2009 · Anne Ulrike Trendelenburg, Angelika Meyer, et al. · American Journal of Physiology-Cell Physiology · 790

Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

2008 · Augusto Villanueva, Derek Y. Chiang, et al. · Gastroenterology · 733

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Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

2008 · C. Florian Bentzinger, Klaas Romanino, et al. · Cell Metabolism · 638

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mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes

2005 · Richard C. Hresko, Mike Mueckler · Journal of Biological Chemistry · 635

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The Mammalian Target of Rapamycin (mTOR) Pathway Regulates Mitochondrial Oxygen Consumption and Oxidative Capacity

2006 · Stefan M. Schieke, Darci Phillips, et al. · Journal of Biological Chemistry · 621

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

2008 · Tsuneo Ikenoue, Ken Inoki, et al. · The EMBO Journal · 610

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mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways

2011 · Pat Gulhati, Kanika A. Bowen, et al. · Cancer Research · 543

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity

2006 · Qian Yang, Ken Inoki, et al. · Genes & Development · 517

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MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation

2015 · Chang-Jun Li, Peng Cheng, et al. · Journal of Clinical Investigation · 509

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

2008 · Valeria Facchinetti, Weiming Ouyang, et al. · The EMBO Journal · 509

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GSK3 and its interactions with the PI3K/AKT/mTOR signalling network

2017 · Miguel A. Hermida, J. Dinesh Kumar, et al. · Advances in Biological Regulation · 478

Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

2010 · Keunwook Lee, Prathyusha Gudapati, et al. · Immunity · 464

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

2007 · Laura R. Pearce, Xu Huang, et al. · Biochemical Journal · 464

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mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

2009 · Louis-Andre Julien, Audrey Carriere, et al. · Molecular and Cellular Biology · 435

Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

2009 · Christian C. Dibble, John M. Asara, et al. · Molecular and Cellular Biology · 423

Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

2009 · Alexander A. Soukas, Elizabeth A. Kane, et al. · Genes & Development · 418

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mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

2009 · David A. Guertin, Deanna M. Stevens, et al. · Cancer Cell · 402

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Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability

2006 · Chiyo Shiota, Jeong-Taek Woo, et al. · Developmental Cell · 389

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Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

2009 · Valérie Risson, Laetitia Mazelin, et al. · The Journal of Cell Biology · 381

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Works count: 2,060

Citation count: 72,610