Keyword

RIG-I

Description: RIG-I is a cytosolic pattern-recognition receptor that detects viral RNA and initiates innate antiviral immune signaling in mammals.

Primary topic: interferon and immune responses (56%)

Wikidata ID: wiki/Q21100537

OpenAlex ID: keywords/rig-i

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

2004 · Mitsutoshi Yoneyama, Mika Kikuchi, et al. · Nature Immunology · 3,932

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 · Hiroki Kato, Osamu Takeuchi, et al. · Nature · 3,881

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

2008 · Hiroki Ishikawa, Glen N. Barber · Nature · 3,543

Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3

2005 · Rashu B. Seth, Lijun Sun, et al. · Cell · 3,317

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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

2005 · Taro Kawai, Ken Takahashi, et al. · Nature Immunology · 2,560

5'-Triphosphate RNA Is the Ligand for RIG-I

2006 · Veit Hornung, Jana Ellegast, et al. · Science · 2,470

A diverse range of gene products are effectors of the type I interferon antiviral response

2011 · John W. Schoggins, Sam J. Wilson, et al. · Nature · 2,434

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

2005 · Etienne Meylan, Joseph Curran, et al. · Nature · 2,399

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RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates

2006 · Andreas Pichlmair, Oliver Schulz, et al. · Science · 2,210

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

2015 · Siqi Liu, Xin Cai, et al. · Science · 1,918

Immune Signaling by RIG-I-like Receptors

2011 · Yueh-Ming Loo, Michael Gale · Immunity · 1,873

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VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling

2005 · Liang-Guo Xu, Yan-Yi Wang, et al. · Molecular Cell · 1,853

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TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

2007 · Michaela U. Gack, Young C. Shin, et al. · Nature · 1,697

Shared and Unique Functions of the DExD/H-Box Helicases RIG-I, MDA5, and LGP2 in Antiviral Innate Immunity

2005 · Mitsutoshi Yoneyama, Mika Kikuchi, et al. · The Journal of Immunology · 1,690

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Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

2008 · Hiroki Kato, Osamu Takeuchi, et al. · The Journal of Experimental Medicine · 1,601

Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

2006 · Kenya Honda, Akinori Takaoka, et al. · Immunity · 1,395

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Cell Type-Specific Involvement of RIG-I in Antiviral Response

2005 · Hiroki Kato, Shintaro Sato, et al. · Immunity · 1,368

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MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

2011 · Fajian Hou, Lijun Sun, et al. · Cell · 1,283

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Biology of Zika Virus Infection in Human Skin Cells

2015 · Rodolphe Hamel, Ophélie Dejarnac, et al. · Journal of Virology · 1,209

Intracellular pattern recognition receptors in the host response

2006 · Etienne Meylan, Jürg Tschopp, et al. · Nature · 1,206

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Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

2006 · Leonid Gitlin, Winfried Barchet, et al. · Proceedings of the National Academy of Sciences · 1,170

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

2007 · Yueh-Ming Loo, Jamie Fornek, et al. · Journal of Virology · 1,071

Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity

2012 · Lam C Tsoi, Sarah L Spain, et al. · Nature Genetics · 1,021

Toll‐like Receptor and RIG‐1‐like Receptor Signaling

2008 · Taro Kawai, Shizuo Akira · Annals of the New York Academy of Sciences · 987

Regulating Intracellular Antiviral Defense and Permissiveness to Hepatitis C Virus RNA Replication through a Cellular RNA Helicase, RIG-I

2005 · Rhea Sumpter, Yueh-Ming Loo, et al. · Journal of Virology · 898

Works count: 5,387

Citation count: 217,300