Keyword

rolipram

Description: A chemical compound that inhibits phosphodiesterase type 4 and is studied for effects on inflammation, neurotransmission, and neurological disorders.

Primary topic: Phosphodiesterase function and regulation (44%)

Wikidata ID: wiki/Q410285

OpenAlex ID: keywords/rolipram

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

2012 · Sung-Jun Park, Faiyaz Ahmad, et al. · Cell · 1,350

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Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus

1996 · M Nibuya, EJ Nestler, et al. · Journal of Neuroscience · 1,207

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cAMP and Schwann cells promote axonal growth and functional recovery after spinal cord injury

2004 · Damien D Pearse, Francisco C Pereira, et al. · Nature Medicine · 727

Amyloid β-peptide inhibition of the PKA/CREB pathway and long-term potentiation: Reversibility by drugs that enhance cAMP signaling

2002 · Ottavio V. Vitolo, Antonino Sant'Angelo, et al. · Proceedings of the National Academy of Sciences · 531

Behavioral Phenotypes of Disc1 Missense Mutations in Mice

2007 · Steven J. Clapcote, Tatiana V. Lipina, et al. · Neuron · 526

mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module

2001 · Kimberly L. Dodge, Samone Khouangsathiene, et al. · The EMBO Journal · 507

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Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein

2002 · Shin Nakagawa, Ji-Eun Kim, et al. · Journal of Neuroscience · 485

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Persistent improvement in synaptic and cognitive functions in an Alzheimer mouse model after rolipram treatment

2004 · Bing Gong, Ottavio V. Vitolo, et al. · Journal of Clinical Investigation · 440

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Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor

2011 · C Anacker, P A Zunszain, et al. · Molecular Psychiatry · 435

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Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory

1998 · Mark Barad, Roussoudan Bourtchouladze, et al. · Proceedings of the National Academy of Sciences · 431

Phosphorylation and Activation of a cAMP-specific Phosphodiesterase by the cAMP-dependent Protein Kinase

1996 · Claudio Sette, Marco Conti · Journal of Biological Chemistry · 409

Biodegradable Nanoparticles for Targeted Drug Delivery in Treatment of Inflammatory Bowel Disease

2001 · Alf Lamprecht, Nathalie Ubrich, et al. · Journal of Pharmacology and Experimental Therapeutics · 403

Anti-Inflammatory and Immunomodulatory Potential of the Novel PDE4 Inhibitor Roflumilast in Vitro

2001 · Armin Hatzelmann, Christian Schudt · Journal of Pharmacology and Experimental Therapeutics · 399

Multistep continuous-flow synthesis of (R)- and (S)-rolipram using heterogeneous catalysts

2015 · Tetsu Tsubogo, Hidekazu Oyamada, et al. · Nature · 396

The Flinders Sensitive Line rat: A selectively bred putative animal model of depression

2005 · David H. Overstreet, Elliot Friedman, et al. · Neuroscience & Biobehavioral Reviews · 380

The role of neurotrophic factors in nerve regeneration

2009 · Tessa Gordon · Neurosurgical FOCUS · 377

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RETRACTED: β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from G s to G i

2003 · George S. Baillie, Arvind Sood, et al. · Proceedings of the National Academy of Sciences · 360

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Oocyte Maturation Involves Compartmentalization and Opposing Changes of cAMP Levels in Follicular Somatic and Germ Cells: Studies Using Selective Phosphodiesterase Inhibitors

1996 · A. Tsafriri, Sang-Young Chun, et al. · Developmental Biology · 348

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The phosphodiesterase inhibitor rolipram delivered after a spinal cord lesion promotes axonal regeneration and functional recovery

2004 · Elena Nikulina, J. Lille Tidwell, et al. · Proceedings of the National Academy of Sciences · 345

The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis

1995 · N. Sommer, P.-A. Löschmann, et al. · Nature Medicine · 345

A mouse model of Rubinstein-Taybi syndrome: Defective long-term memory is ameliorated by inhibitors of phosphodiesterase 4

2003 · Rusiko Bourtchouladze, Regina Lidge, et al. · Proceedings of the National Academy of Sciences · 313

The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors

1987 · M L Reeves, B K Leigh, et al. · Biochemical Journal · 305

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Selective inhibition of cyclic nucleotide phosphodiesterases of human, bovine and rat aorta

1986 · C. Lugnier, P. Schoeffter, et al. · Biochemical Pharmacology · 301

The role of cyclic AMP signaling in promoting axonal regeneration after spinal cord injury

2007 · Sari S. Hannila, Marie T. Filbin · Experimental Neurology · 288

Distinct Roles of PDE4 and PDE10A in the Regulation of cAMP/PKA Signaling in the Striatum

2008 · Akinori Nishi, Mahomi Kuroiwa, et al. · Journal of Neuroscience · 286

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Works count: 2,821

Citation count: 91,430