Keyword

self-tolerance

Description: Self-tolerance is the immune system’s normal ability to avoid mounting harmful responses against the body’s own antigens.

Primary topic: T-cell and B-cell Immunology (54%)

Wikidata ID: wiki/Q71131273

OpenAlex ID: keywords/self-tolerance

The blockade of immune checkpoints in cancer immunotherapy

2012 · Drew M. Pardoll · Nature reviews. Cancer · 13,796

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Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 · Shohei Hori, Takashi Nomura, et al. · Science · 8,189

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 · Jung-Hyun Park, Stanley Adoro, et al. · Nature Immunology · 5,835

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases

1995 · S Sakaguchi, N Sakaguchi, et al. · The Journal of Immunology · 5,604

Regulatory T Cells and Immune Tolerance

2008 · Shimon Sakaguchi, Tomoyuki Yamaguchi, et al. · Cell · 5,335

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Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

2015 · Suzanne L. Topalian, Charles G. Drake, et al. · Cancer Cell · 4,215

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Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade

2002 · Yoshiko Iwai, Masayoshi Ishida, et al. · Proceedings of the National Academy of Sciences · 3,204

Innate or Adaptive Immunity? The Example of Natural Killer Cells

2011 · Eric Vivier, David H. Raulet, et al. · Science · 2,812

In search of the ‘missing self’: MHC molecules and NK cell recognition

1990 · Hans-Gustaf Ljunggren, Klas Kärre · Immunology Today · 2,690

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 · Shimon Sakaguchi · Nature Immunology · 2,674

The clonal selection theory of acquired immunity

1959 · F. M. Burnet · Vanderbilt University Press eBooks · 2,642

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FOXP3+ regulatory T cells in the human immune system

2010 · Shimon Sakaguchi, Makoto Miyara, et al. · Nature reviews. Immunology · 2,441

TRANSFORMING GROWTH FACTOR-β REGULATION OF IMMUNE RESPONSES

2005 · Ming O. Li, Yisong Y. Wan, et al. · Annual Review of Immunology · 2,208

Selective rejection of H–2-deficient lymphoma variants suggests alternative immune defence strategy

1986 · Klas Kärre, Hans Gustaf Ljunggren, et al. · Nature · 2,162

Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

2006 · Jeong M Kim, Jeffrey P Rasmussen, et al. · Nature Immunology · 1,822

Regulatory T Cells

2000 · Shimon Sakaguchi · Cell · 1,818

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Stimulation of CD25+CD4+ regulatory T cells through GITR breaks immunological self-tolerance

2002 · Jun Shimizu, Sayuri Yamazaki, et al. · Nature Immunology · 1,729

CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity

2002 · Yasmine Belkaid, Ciriaco A. Piccirillo, et al. · Nature · 1,725

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

1988 · Pawel Kisielow, Horst Blüthmann, et al. · Nature · 1,682

Immune Inhibitory Molecules LAG-3 and PD-1 Synergistically Regulate T-cell Function to Promote Tumoral Immune Escape

2011 · Seng-Ryong Woo, Meghan E. Turnis, et al. · Cancer Research · 1,644

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Positive and Negative Selection of T Cells

2003 · Timothy K. Starr, Stephen C. Jameson, et al. · Annual Review of Immunology · 1,603

Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma

2003 · Giao Q. Phan, James C. Yang, et al. · Proceedings of the National Academy of Sciences · 1,577

NFAT proteins: key regulators of T-cell development and function

2005 · Fernando Macian · Nature reviews. Immunology · 1,572

Immune-Neuro-Endocrine Interactions: Facts and Hypotheses

1996 · HUGO OSCAR BESEDOVSKY, ADRIANA DEL REY · Endocrine Reviews · 1,564

Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease

2006 · Shimon Sakaguchi, Masahiro Ono, et al. · Immunological Reviews · 1,555

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Works count: 6,830

Citation count: 376,700