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Keyword

senolytics

Description: Senolytics are agents investigated for selectively inducing the death of senescent cells in aging research and potential therapies.
Wikidata ID: wiki/Q19587281
OpenAlex ID: keywords/senolytics
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
2011 · Darren J. Baker, Tobias Wijshake, et al. · Nature · 3,663
Ageing as a risk factor for neurodegenerative disease
2019 · Yujun Hou, Xiuli Dan, et al. · Nature Reviews Neurology · 3,289
Cellular senescence: from physiology to pathology
2014 · Daniel Muñoz-Espín, Manuel Serrano · Nature Reviews Molecular Cell Biology · 2,812
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
2016 · Darren J. Baker, Bennett G. Childs, et al. · Nature · 2,801
The role of senescent cells in ageing
2014 · Jan M. van Deursen · Nature · 2,616
Hallmarks of Cellular Senescence
2018 · Alejandra Hernandez-Segura, Jamil Nehme, et al. · Trends in Cell Biology · 2,587
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The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
2015 · Yi Zhu, Tamara Tchkonia, et al. · Aging Cell · 2,495
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Cellular senescence in aging and age-related disease: from mechanisms to therapy
2015 · Bennett G Childs, Matej Durik, et al. · Nature Medicine · 2,349
Senolytics improve physical function and increase lifespan in old age
2018 · Ming Xu, Tamar Pirtskhalava, et al. · Nature Medicine · 2,276
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
2015 · Jianhui Chang, Yingying Wang, et al. · Nature Medicine · 1,811
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities
2013 · Tamara Tchkonia, Yi Zhu, et al. · Journal of Clinical Investigation · 1,771
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Senescence in Health and Disease
2017 · Shenghui He, Norman E. Sharpless · Cell · 1,759
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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
2022 · Jun Guo, Xiuqing Huang, et al. · Signal Transduction and Targeted Therapy · 1,731
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Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
2021 · Ruchi Kumari, Parmjit Jat · Frontiers in Cell and Developmental Biology · 1,618
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Cellular senescence mediates fibrotic pulmonary disease
2017 · Marissa J. Schafer, Thomas A. White, et al. · Nature Communications · 1,606
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Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
2017 · Ok Hee Jeon, Chaekyu Kim, et al. · Nature Medicine · 1,503
Facing up to the global challenges of ageing
2018 · Linda Partridge, Joris Deelen, et al. · Nature · 1,466
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
2017 · Marjolein P. Baar, Renata M.C. Brandt, et al. · Cell · 1,452
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Inflammation and aging: signaling pathways and intervention therapies
2023 · Xia Li, Chentao Li, et al. · Signal Transduction and Targeted Therapy · 1,425
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Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
2019 · LaTonya J. Hickson, Larissa G.P. Langhi Prata, et al. · EBioMedicine · 1,375
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Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse
2016 · Marco Demaria, Monique N. O'Leary, et al. · Cancer Discovery · 1,328
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Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
2018 · Tyler J. Bussian, Asef Aziz, et al. · Nature · 1,287
Senescent cells: an emerging target for diseases of ageing
2017 · Bennett G. Childs, Martina Gluscevic, et al. · Nature Reviews Drug Discovery · 1,273
Cellular Senescence: Aging, Cancer, and Injury
2019 · Arianna Calcinotto, Jaskaren Kohli, et al. · Physiological Reviews · 1,267
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Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study
2019 · Jamie N. Justice, Anoop M. Nambiar, et al. · EBioMedicine · 1,256
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Works count: 5,148
Citation count: 191,500
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