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Keyword

Shank2

Description: A human protein-coding gene that encodes a synaptic scaffolding protein and is studied in neuroscience and disease genetics.
Wikidata ID: wiki/Q18036609
OpenAlex ID: keywords/shank2
Functional impact of global rare copy number variation in autism spectrum disorders
2010 · Dalila Pinto, Alistair T. Pagnamenta, et al. · Nature · 2,009
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Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function
2012 · Hyejung Won, Hye-Ryeon Lee, et al. · Nature · 693
SHANK proteins: roles at the synapse and in autism spectrum disorder
2017 · Patricia Monteiro, Guoping Feng · Nature reviews. Neuroscience · 679
Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2
2012 · Michael J. Schmeisser, Elodie Ey, et al. · Nature · 638
Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments
2014 · Claire S. Leblond, Caroline Nava, et al. · PLoS Genetics · 630
Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation
2010 · Simone Berkel, Christian R Marshall, et al. · Nature Genetics · 564
Modeling Autism by SHANK Gene Mutations in Mice
2013 · Yong-hui Jiang, Michael D. Ehlers · Neuron · 488
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Genetic and Functional Analyses of SHANK2 Mutations Suggest a Multiple Hit Model of Autism Spectrum Disorders
2012 · Claire S. Leblond, Jutta Heinrich, et al. · PLoS Genetics · 430
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Characterization of the Shank Family of Synaptic Proteins
1999 · Sangmi Lim, Scott Naisbitt, et al. · Journal of Biological Chemistry · 295
Destabilization of the Postsynaptic Density by PSD-95 Serine 73 Phosphorylation Inhibits Spine Growth and Synaptic Plasticity
2008 · Pascal Steiner, Michael J. Higley, et al. · Neuron · 259
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The emerging role of SHANK genes in neuropsychiatric disorders
2013 · Audrey Guilmatre, Guillaume Huguet, et al. · Developmental Neurobiology · 237
Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation
2011 · Andreas M Grabrucker, Mary J Knight, et al. · The EMBO Journal · 228
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Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
2016 · Saša Peter, Michiel M. ten Brinke, et al. · Nature Communications · 224
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Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders
2013 · Stefanie Grabrucker, Linda Jannetti, et al. · Brain · 175
SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons
2019 · Kirill Zaslavsky, Wen-Bo Zhang, et al. · Nature Neuroscience · 174
Postsynaptic Density Assembly Is Fundamentally Different from Presynaptic Active Zone Assembly
2004 · Tal Bresler, Mika Shapira, et al. · Journal of Neuroscience · 170
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Inherited and de novo SHANK2 variants associated with autism spectrum disorder impair neuronal morphogenesis and physiology
2011 · Simone Berkel, Wannan Tang, et al. · Human Molecular Genetics · 162
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Genomic Characterization of Esophageal Squamous Cell Carcinoma Reveals Critical Genes Underlying Tumorigenesis and Poor Prognosis
2016 · Hai-De Qin, Xiao-Yu Liao, et al. · The American Journal of Human Genetics · 151
Differential expression and dendritic transcript localization of Shank family members: identification of a dendritic targeting element in the 3′ untranslated region of Shank1 mRNA
2004 · Tobias M. Böckers, Mailin Segger-Junius, et al. · Molecular and Cellular Neuroscience · 149
The Autism ProSAP1/Shank2 mouse model displays quantitative and structural abnormalities in ultrasonic vocalisations
2013 · Elodie Ey, Nicolas Torquet, et al. · Behavioural Brain Research · 140
Linkage of the Actin Cytoskeleton to the Postsynaptic Density via Direct Interactions of Abp1 with the ProSAP/Shank Family
2004 · Britta Qualmann, Tobias M. Boeckers, et al. · Journal of Neuroscience · 134
Direct interaction of GluRδ2 with Shank scaffold proteins in cerebellar Purkinje cells
2004 · Takeshi Uemura, Hisashi Mori, et al. · Molecular and Cellular Neuroscience · 119
Breakpoint mapping by next generation sequencing reveals causative gene disruption in patients carrying apparently balanced chromosome rearrangements with intellectual deficiency and/or congenital malformations
2013 · Caroline Schluth-Bolard, Audrey Labalme, et al. · Journal of Medical Genetics · 113
Trans-synaptic zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation
2015 · Eun-Jae Lee, Hyejin Lee, et al. · Nature Communications · 110
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Cerebellar Shank2 Regulates Excitatory Synapse Density, Motor Coordination, and Specific Repetitive and Anxiety-Like Behaviors
2016 · Seungmin Ha, Dongwon Lee, et al. · Journal of Neuroscience · 109
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Works count: 644
Citation count: 14,770
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