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Keyword

SHP2

Description: A non-receptor protein tyrosine phosphatase encoded by PTPN11 that regulates cellular signaling, including immune and growth-factor pathways.
Wikidata ID: wiki/Q7120997
OpenAlex ID: keywords/shp2
The pro- and anti-inflammatory properties of the cytokine interleukin-6
2011 · Jürgen Scheller, Athena Chalaris, et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 3,214
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
1998 · Peter C. HEINRICH, Iris BEHRMANN, et al. · Biochemical Journal · 2,128
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Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice
1998 · Christine Bole-Feysot, Vincent Goffin, et al. · Endocrine Reviews · 1,939
Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome
2001 · Marco Tartaglia, Ernest L. Mehler, et al. · Nature Genetics · 1,734
T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition
2017 · Enfu Hui, Jeanne Cheung, et al. · Science · 1,675
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Nk Cell Receptors
1998 · Lewis L. Lanier · Annual Review of Immunology · 1,650
PD-1 and PD-1 ligands: from discovery to clinical application
2007 · T. Okazaki, T. Honjo · International Immunology · 1,309
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SHP-1 and SHP-2 Associate with Immunoreceptor Tyrosine-Based Switch Motif of Programmed Death 1 upon Primary Human T Cell Stimulation, but Only Receptor Ligation Prevents T Cell Activation
2004 · Jens M Chemnitz, Richard V Parry, et al. · The Journal of Immunology · 1,242
The ‘Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
2003 · Benjamin G. Neel, Haihua Gu, et al. · Trends in Biochemical Sciences · 1,238
Programmed cell death 1 forms negative costimulatory microclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2
2012 · Tadashi Yokosuka, Masako Takamatsu, et al. · The Journal of Experimental Medicine · 1,149
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Reversible Oxidation and Inactivation of Protein Tyrosine Phosphatases In Vivo
2002 · Tzu-Ching Meng, Toshiyuki Fukada, et al. · Molecular Cell · 1,039
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SHP-2 Tyrosine Phosphatase as an Intracellular Target of Helicobacter pylori CagA Protein
2002 · Hideaki Higashi, Ryouhei Tsutsumi, et al. · Science · 1,030
Crystal Structure of the Tyrosine Phosphatase SHP-2
1998 · Peter Hof, Scott Pluskey, et al. · Cell · 986
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The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM
1998 · J. Sayos, C. Wu, et al. · Nature · 943
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases
2016 · Ying-Nan P. Chen, Matthew J. LaMarche, et al. · Nature · 905
STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells
1999 · Takahiko Matsuda, Takanori Nakamura, et al. · The EMBO Journal · 895
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BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
2003 · Norihiko Watanabe, Maya Gavrieli, et al. · Nature Immunology · 882
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
2001 · Taku Okazaki, Akito Maeda, et al. · Proceedings of the National Academy of Sciences · 848
PTPN11 Mutations in Noonan Syndrome: Molecular Spectrum, Genotype-Phenotype Correlation, and Phenotypic Heterogeneity
2002 · Marco Tartaglia, Kamini Kalidas, et al. · The American Journal of Human Genetics · 803
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Activation of Downstream Signals by the Long Form of the Leptin Receptor
2000 · Alexander S. Banks, Sarah M. Davis, et al. · Journal of Biological Chemistry · 797
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PD‐1 inhibits T‐cell receptor induced phosphorylation of the ZAP70/CD3ζ signalosome and downstream signaling to PKCθ
2004 · Kelly-Ann Sheppard, Lori J. Fitz, et al. · FEBS Letters · 789
Interleukin 6 and its Receptor: Ten Years Later
1998 · Toshio Hirano · International Reviews of Immunology · 788
Germline KRAS mutations cause Noonan syndrome
2006 · Suzanne Schubbert, Martin Zenker, et al. · Nature Genetics · 731
Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
2010 · Xonia Carvajal-Vergara, Ana Sevilla, et al. · Nature · 689
Molecular Basis of T Cell Inactivation by CTLA-4
1998 · Kyung-Mi Lee, Ellen Chuang, et al. · Science · 685
Works count: 5,980
Citation count: 208,900
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