Keyword

shRNA

Description: A short hairpin RNA is a small RNA molecule that forms a hairpin structure and can silence specific genes through RNA interference.

Primary topic: RNA Interference and Gene Delivery (27%)

Wikidata ID: wiki/Q1950808

OpenAlex ID: keywords/shrna

Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs

2003 · Rui Yi, Yi Qin, et al. · Genes & Development · 3,011

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Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways

2006 · Dirk Grimm, Konrad L. Streetz, et al. · Nature · 1,675

Short hairpin RNAs (shRNAs) induce sequence-specific silencing in mammalian cells

2002 · Patrick J. Paddison, Amy A. Caudy, et al. · Genes & Development · 1,553

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A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference

2003 · Douglas A Rubinson, Christopher P Dillon, et al. · Nature Genetics · 1,502

Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition

2016 · Leonid Cherkassky, Aurore Morello, et al. · Journal of Clinical Investigation · 1,076

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

2004 · Katrien Berns, E. Marielle Hijmans, et al. · Nature Cell Biology · 1,065

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RNA interference in adult mice

2002 · Anton P. McCaffrey, Leonard Meuse, et al. · Nature · 1,060

A Versatile Viral System for Expression and Depletion of Proteins in Mammalian Cells

2009 · Eric Campeau, Victoria E. Ruhl, et al. · PLoS ONE · 967

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Induction of an interferon response by RNAi vectors in mammalian cells

2003 · Alan J Bridge, Stephanie Pebernard, et al. · Nature Genetics · 961

Dissecting self-renewal in stem cells with RNA interference

2006 · Natalia Ivanova, Radu Dobrin, et al. · Nature · 960

Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity

2006 · Aimee L. Jackson, Julja Burchard, et al. · RNA · 956

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Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs

2008 · Joshua E. Babiarz, J. Graham Ruby, et al. · Genes & Development · 908

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Activating mutations in ALK provide a therapeutic target in neuroblastoma

2008 · Rani E. George, Takaomi Sanda, et al. · Nature · 897

A genome-scale shRNA resource for transgenic RNAi in Drosophila

2011 · Jian-Quan Ni, Rui Zhou, et al. · Nature Methods · 809

The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo

2011 · Kristen L. Meerbrey, Guang Hu, et al. · Proceedings of the National Academy of Sciences · 667

siRNA vs. shRNA: Similarities and differences

2009 · Donald D. Rao, John S. Vorhies, et al. · Advanced Drug Delivery Reviews · 662

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia

2004 · Haibin Xia, Qinwen Mao, et al. · Nature Medicine · 653

The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells

2006 · Qin Shen, Yue Wang, et al. · Nature Neuroscience · 625

Cre-lox-regulated conditional RNA interference from transgenes

2004 · Andrea Ventura, Alexander Meissner, et al. · Proceedings of the National Academy of Sciences · 625

Second-generation shRNA libraries covering the mouse and human genomes

2005 · Jose M Silva, Mamie Z Li, et al. · Nature Genetics · 624

Inhibition of hepatitis B virus in mice by RNA interference

2003 · Anton P McCaffrey, Hiroyuki Nakai, et al. · Nature Biotechnology · 607

PsRobot: a web-based plant small RNA meta-analysis toolbox

2012 · Hua-Jun Wu, Ying-Ke Ma, et al. · Nucleic Acids Research · 569

RNAi reveals doublecortin is required for radial migration in rat neocortex

2003 · Jilin Bai, Raddy L Ramos, et al. · Nature Neuroscience · 537

A lentiviral microRNA-based system for single-copy polymerase II-regulated RNA interference in mammalian cells

2005 · Frank Stegmeier, Guang Hu, et al. · Proceedings of the National Academy of Sciences · 532

The JAK2 Inhibitor AZD1480 Potently Blocks Stat3 Signaling and Oncogenesis in Solid Tumors

2009 · Michael Hedvat, Dennis Huszar, et al. · Cancer Cell · 526

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Works count: 8,427

Citation count: 135,100