Keyword

SMARCA2

Description: SMARCA2 is a human protein-coding gene encoding an ATP-dependent chromatin-remodeling protein involved in regulating gene expression.

Primary topic: Chromatin Remodeling and Cancer (38%)

Wikidata ID: wiki/Q18031593

OpenAlex ID: keywords/smarca2

BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

2019 · William Farnaby, Manfred Koegl, et al. · Nature Chemical Biology · 542

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Mutations affecting components of the SWI/SNF complex cause Coffin-Siris syndrome

2012 · Yoshinori Tsurusaki, Nobuhiko Okamoto, et al. · Nature Genetics · 518

The mutational landscape of adenoid cystic carcinoma

2013 · Allen S Ho, Kasthuri Kannan, et al. · Nature Genetics · 468

Targeting SWI/SNF ATPases in enhancer-addicted prostate cancer

2021 · Lanbo Xiao, Abhijit Parolia, et al. · Nature · 313

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A Synthetic Lethality–Based Strategy to Treat Cancers Harboring a Genetic Deficiency in the Chromatin Remodeling Factor BRG1

2013 · Takahiro Oike, Hideaki Ogiwara, et al. · Cancer Research · 294

The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies

2015 · Bhavatarini Vangamudi, Thomas A. Paul, et al. · Cancer Research · 272

SWI/SNF Complex–deficient Undifferentiated/Rhabdoid Carcinomas of the Gastrointestinal Tract

2015 · Abbas Agaimy, Ondrej Daum, et al. · The American Journal of Surgical Pathology · 242

Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome

2012 · Jeroen K J Van Houdt, Beata Anna Nowakowska, et al. · Nature Genetics · 239

Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers

2018 · Julien P. N. Papillon, Katsumasa Nakajima, et al. · Journal of Medicinal Chemistry · 230

A comprehensive molecular study on Coffin–Siris and Nicolaides–Baraitser syndromes identifies a broad molecular and clinical spectrum converging on altered chromatin remodeling

2013 · Dagmar Wieczorek, Nina Bögershausen, et al. · Human Molecular Genetics · 223

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Convergent structural alterations define SWItch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer

2011 · A. Hunter Shain, Craig P. Giacomini, et al. · Proceedings of the National Academy of Sciences · 221

Coffin-Siris Syndrome and the BAF Complex: Genotype-Phenotype Study in 63 Patients

2013 · Gijs W.E. Santen, Emmelien Aten, et al. · Human Mutation · 220

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

2022 · Christiane Kofink, Nicole Trainor, et al. · Nature Communications · 217

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Dual loss of the SWI / SNF complex ATPases SMARCA4 / BRG1 and SMARCA2 / BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type

2015 · Anthony N Karnezis, Yemin Wang, et al. · The Journal of Pathology · 217

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SMARCA4-deficient Thoracic Sarcomas

2018 · Raul Perret, Lara Chalabreysse, et al. · The American Journal of Surgical Pathology · 200

A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms

2020 · Nazar Mashtalir, Hiroshi Suzuki, et al. · Cell · 198

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SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

2019 · Yibo Xue, Brian Meehan, et al. · Nature Communications · 187

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SMARCA4 and SMARCA2 deficiency in non–small cell lung cancer: immunohistochemical survey of 316 consecutive specimens

2016 · Esther Herpel, Ralf J. Rieker, et al. · Annals of Diagnostic Pathology · 176

Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models

2017 · Elayne Chan-Penebre, Kelli Armstrong, et al. · Molecular Cancer Therapeutics · 171

Loss of switch/sucrose non-fermenting complex protein expression is associated with dedifferentiation in endometrial carcinomas

2016 · Anthony N Karnezis, Lien N Hoang, et al. · Modern Pathology · 157

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Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients

2020 · Tharu M. Fernando, Robert Piskol, et al. · Nature Communications · 155

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Alcohol Alters DNA Methylation Patterns and Inhibits Neural Stem Cell Differentiation

2011 · Feng C. Zhou, Yokesh Balaraman, et al. · Alcoholism Clinical and Experimental Research · 153

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Affinity and cooperativity modulate ternary complex formation to drive targeted protein degradation

2023 · Ryan P. Wurz, Huan Rui, et al. · Nature Communications · 149

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Mutational Landscapes and Phenotypic Spectrum of SWI/SNF-Related Intellectual Disability Disorders

2018 · Nina Bögershausen, Bernd Wollnik · Frontiers in Molecular Neuroscience · 143

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Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers

2022 · Jennifer Cantley, Xiaofen Ye, et al. · Nature Communications · 141

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Works count: 738

Citation count: 13,760