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Keyword

SOAT1

Description: A protein-coding gene whose product is involved in cholesterol esterification and lipid metabolism, studied in cancer and other biomedical contexts.
Wikidata ID: wiki/Q18031641
OpenAlex ID: keywords/soat1
Proteomics identifies new therapeutic targets of early-stage hepatocellular carcinoma
2019 · Ying Jiang, Aihua Sun, et al. · Nature · 947
Cholesterol metabolism: New functions and therapeutic approaches in cancer
2020 · Huanji Xu, Sheng Zhou, et al. · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · 365
Inhibition of SOAT1 Suppresses Glioblastoma Growth via Blocking SREBP-1–Mediated Lipogenesis
2016 · Feng Geng, Xiang Cheng, et al. · Clinical Cancer Research · 328
Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells
2015 · Silviu Sbiera, Ellen Leich, et al. · Endocrinology · 191
Local TNF causes NFATc1-dependent cholesterol-mediated podocyte injury
2016 · Christopher E. Pedigo, Gloria Michelle Ducasa, et al. · Journal of Clinical Investigation · 190
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ATP-binding cassette A1 deficiency causes cardiolipin-driven mitochondrial dysfunction in podocytes
2019 · G. Michelle Ducasa, Alla Mitrofanova, et al. · Journal of Clinical Investigation · 175
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The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis
2022 · Zhi Lin, Jiao Liu, et al. · Nature Communications · 150
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Convergence of genes implicated in Alzheimer's disease on the cerebral cholesterol shuttle: APP, cholesterol, lipoproteins, and atherosclerosis
2006 · C.J. Carter · Neurochemistry International · 150
SOAT1 promotes mevalonate pathway dependency in pancreatic cancer
2020 · Tobiloba E. Oni, Giulia Biffi, et al. · The Journal of Experimental Medicine · 122
Cholesterol uptake and regulation in high-grade and lethal prostate cancers
2017 · Konrad H Stopsack, Travis A Gerke, et al. · Carcinogenesis · 116
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ACAT1/SOAT1 as a Therapeutic Target for Alzheimer's Disease
2015 · Yohei Shibuya, Catherine CY Chang, et al. · Future Medicinal Chemistry · 113
Inhibiting ACAT1/SOAT1 in Microglia Stimulates Autophagy-Mediated Lysosomal Proteolysis and Increases Aβ1–42 Clearance
2014 · Yohei Shibuya, Catherine C.Y. Chang, et al. · Journal of Neuroscience · 107
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The ER membrane protein complex promotes biogenesis of sterol-related enzymes maintaining cholesterol homeostasis
2018 · Norbert Volkmar, Maria-Laetitia Thezenas, et al. · Journal of Cell Science · 105
Focus on Alzheimer's Disease and Related Disorders
2005 · Andreas Papassotiropoulos, M. Axel Wollmer, et al. · The Journal of Clinical Psychiatry · 104
Structure of nevanimibe-bound tetrameric human ACAT1
2020 · Tao Long, Yingyuan Sun, et al. · Nature · 97
Lipid Metabolism in Glioblastoma: From De Novo Synthesis to Storage
2022 · Yongjun Kou, Feng Geng, et al. · Biomedicines · 95
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Structural insights into the inhibition mechanism of human sterol O-acyltransferase 1 by a competitive inhibitor
2020 · Chengcheng Guan, Yange Niu, et al. · Nature Communications · 85
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Lipid droplets, potential biomarker and metabolic target in glioblastoma
2017 · Deliang Guo · Internal Medicine Review · 82
P53 deficiency affects cholesterol esterification to exacerbate hepatocarcinogenesis
2022 · Yahui Zhu, Li Gu, et al. · Hepatology · 78
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The UBIAD1 Prenyltransferase Links Menaquione-4 Synthesis to Cholesterol Metabolic Enzymes
2012 · Michael L. Nickerson, Allen D. Bosley, et al. · Human Mutation · 71
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Cholesterol-binding motifs in STING that control endoplasmic reticulum retention mediate anti-tumoral activity of cholesterol-lowering compounds
2024 · Bao-cun Zhang, Marlene F. Laursen, et al. · Nature Communications · 68
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Gene Expression Profiles of Human Trabecular Meshwork Cells Induced by Triamcinolone and Dexamethasone
2008 · Bao Jian Fan, Dan Yi Wang, et al. · Investigative Ophthalmology & Visual Science · 68
Membrane plasmalogen composition and cellular cholesterol regulation: a structure activity study
2010 · Rishikesh Mankidy, Pearson WK Ahiahonu, et al. · Lipids in Health and Disease · 66
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Sterol-O-acyltransferase-1 has a role in kidney disease associated with diabetes and Alport syndrome
2020 · Xiaochen Liu, Gloria Michelle Ducasa, et al. · Kidney International · 58
Genetic association of acyl-coenzyme A: cholesterol acyltransferase with cerebrospinal fluid cholesterol levels, brain amyloid load, and risk for Alzheimer's disease
2003 · M A Wollmer, J R Streffer, et al. · Molecular Psychiatry · 58
Works count: 367
Citation count: 6,316
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