Keyword

solid-phase synthesis

Description: A chemical synthesis method in which molecules are built or modified while attached to an insoluble solid support.

Primary topic: Chemical Synthesis and Analysis (35%)

Wikidata ID: wiki/Q2026994

OpenAlex ID: keywords/solid-phase-synthesis

CuI‐Catalyzed Alkyne–Azide “Click” Cycloadditions from a Mechanistic and Synthetic Perspective

2005 · Victoria D. Bock, Henk Hiemstra, et al. · European Journal of Organic Chemistry · 1,451

Recent Advances in the Biginelli Dihydropyrimidine Synthesis. New Tricks from an Old Dog

2000 · C. Oliver Kappe · Accounts of Chemical Research · 1,106

Solid Phase Synthesis

1986 · Bruce Merrifield · Science · 1,005

Automated Solid-Phase Synthesis of Oligosaccharides

2001 · Obadiah J. Plante, Emma R. Palmacci, et al. · Science · 933

Synthesis of deoxyoligonucleotides on a polymer support

1981 · M. D. Matteucci, M. H. Caruthers · Journal of the American Chemical Society · 889

Synthesis of long prebiotic oligomers on mineral surfaces

1996 · James P. Ferris, Aubrey R. Hill, et al. · Nature · 865

Gene Synthesis Machines: DNA Chemistry and Its Uses

1985 · Marvin H. Caruthers · Science · 785

Combinatorial Synthesis of Small Organic Molecules

1996 · Friedhelm Balkenhohl, Christoph von dem Bussche‐Hünnefeld, et al. · Angewandte Chemie International Edition in English · 726

The “One-Bead-One-Compound” Combinatorial Library Method

1997 · Kit S. Lam, Michal Lebl, et al. · Chemical Reviews · 714

Advances in the Synthesis of Oligonucleotides by the Phosphoramidite Approach

1992 · Serge L. Beaucage, Radhakrishman P. Iyer · Tetrahedron · 714

Multi-step organic synthesis using solid-supported reagents and scavengers: a new paradigm in chemical library generation

2000 · Steven V. Ley, Ian R. Baxendale, et al. · Journal of the Chemical Society Perkin Transactions 1 · 693

Natural Product-like Combinatorial Libraries Based on Privileged Structures. 1. General Principles and Solid-Phase Synthesis of Benzopyrans

2000 · K. C. Nicolaou, J. A. Pfefferkorn, et al. · Journal of the American Chemical Society · 678

Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides

2008 · Nathaniel P. Chongsiriwatana, James A. Patch, et al. · Proceedings of the National Academy of Sciences · 658

The Mizoroki–Heck Reaction

2009 · Wiley eBooks · 635

Polymer-supported reactions in organic synthesis

1980 · Philip Hodge, D. C. Sherrington · Medical Entomology and Zoology · 632

The Current Status of Heterocyclic Combinatorial Libraries

1997 · Adel Nefzi, John M. Ostresh, et al. · Chemical Reviews · 586

New Designs of Macroporous Polymers and Supports: From Separation to Biocatalysis

1996 · Frantisek Svec, Jean M. J. Fréchet · Science · 586

Bleomycin: New Perspectives on the Mechanism of Action

1999 · Sidney M. Hecht · Journal of Natural Products · 561

Solid-Phase Synthesis of Highly Fluorescent Nitrogen-Doped Carbon Dots for Sensitive and Selective Probing Ferric Ions in Living Cells

2014 · Haijuan Zhang, Yonglei Chen, et al. · Analytical Chemistry · 511

Fluorous Synthesis: A Fluorous-Phase Strategy for Improving Separation Efficiency in Organic Synthesis

1997 · Armido Studer, Sabine Hadida, et al. · Science · 502

Preparation, structure and morphology of polymer supports

1998 · David C. Sherrington · Chemical Communications · 495

Sequence-specific polypeptoids: A diverse family of heteropolymers with stable secondary structure

1998 · Kent Kirshenbaum, Annelise E. Barron, et al. · Proceedings of the National Academy of Sciences · 483

Oligonucleotide synthesis : a practical approach

1984 · Michael J. Gait · IRL Press eBooks · 482

Peptoid Polymers: A Highly Designable Bioinspired Material

2013 · Jing Sun, Ronald N. Zuckermann · ACS Nano · 458

Copper-Catalyzed Hydrative Amide Synthesis with Terminal Alkyne, Sulfonyl Azide, and Water

2005 · Seung Hwan Cho, Eun Jeong Yoo, et al. · Journal of the American Chemical Society · 448

Works count: 12,540

Citation count: 221,800