Keyword

split intein

Description: A protein segment divided into two parts that can reconstitute and catalyze the ligation of the protein fragments, used in molecular biology.

Primary topic: Biochemical and Structural Characterization (62%)

OpenAlex ID: keywords/split-intein

Production of cyclic peptides and proteins in vivo

1999 · Charles P. Scott, Ernesto Abel-Santos, et al. · Proceedings of the National Academy of Sciences · 402

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Protein trans -splicing by a split intein encoded in a split DnaE gene of Synechocystis sp. PCC6803

1998 · Hong Wu, Zhuma Hu, et al. · Proceedings of the National Academy of Sciences · 373

Development of an intein-mediated split–Cas9 system for gene therapy

2015 · Dong-Jiunn Jeffery Truong, Karin Kühner, et al. · Nucleic Acids Research · 371

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Highly efficient protein trans ‐splicing by a naturally split DnaE intein from Nostoc punctiforme

2006 · Hideo Iwai, Sara Züger, et al. · FEBS Letters · 273

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Bacterial superglue enables easy development of efficient virus-like particle based vaccines

2016 · Susan Thrane, Christoph M. Janitzek, et al. · Journal of Nanobiotechnology · 204

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Intein-mediated protein trans-splicing expands adeno-associated virus transfer capacity in the retina

2019 · Patrizia Tornabene, Ivana Trapani, et al. · Science Translational Medicine · 191

Protein trans-Splicing and Cyclization by a Naturally Split Intein from the dnaE Gene ofSynechocystis Species PCC6803

2000 · Thomas C. Evans, Deana Martin, et al. · Journal of Biological Chemistry · 188

Unprecedented Rates and Efficiencies Revealed for New Natural Split Inteins from Metagenomic Sources

2012 · Patricia Carvajal-Vallejos, Roser Pallissé, et al. · Journal of Biological Chemistry · 181

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Design of a Split Intein with Exceptional Protein Splicing Activity

2016 · Adam J. Stevens, Zachary Z. Brown, et al. · Journal of the American Chemical Society · 175

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Protein Semi-Synthesis in Living Cells

2003 · Izabela Giriat, Tom W. Muir · Journal of the American Chemical Society · 167

Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins

2015 · Yael David, Miquel Vila-Perelló, et al. · Nature Chemistry · 157

PROTEIN-SPLICING INTEIN: Genetic Mobility, Origin, and Evolution

2000 · Xiang-Qin Liu · Annual Review of Genetics · 149

Ultrafast Protein Splicing is Common among Cyanobacterial Split Inteins: Implications for Protein Engineering

2012 · Neel H. Shah, Geoffrey P. Dann, et al. · Journal of the American Chemical Society · 144

Split Inteins as Versatile Tools for Protein Semisynthesis

2009 · Henning D. Mootz · ChemBioChem · 141

Intein Applications: From Protein Purification and Labeling to Metabolic Control Methods

2014 · David W. Wood, Julio A. Camarero · Journal of Biological Chemistry · 138

A promiscuous split intein with expanded protein engineering applications

2017 · Adam J. Stevens, Giridhar Sekar, et al. · Proceedings of the National Academy of Sciences · 130

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Evolution of cyclic peptide protease inhibitors

2011 · Travis S. Young, Douglas D. Young, et al. · Proceedings of the National Academy of Sciences · 128

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Development of a Tandem Protein Trans-Splicing System Based on Native and Engineered Split Inteins

2005 · Jianxin Shi, Tom W. Muir · Journal of the American Chemical Society · 128

Characterization of a Naturally Occurring Trans-Splicing Intein fromSynechocystissp. PCC6803

2001 · Deana D. Martin, Ming-Qun Xu, et al. · Biochemistry · 126

Synthetic Two-piece and Three-piece Split Inteins for Protein trans-Splicing

2004 · Wenchang Sun, Jing Yang, et al. · Journal of Biological Chemistry · 117

Nature's recipe for splitting inteins

2014 · A. S. Aranko, A. Wlodawer, et al. · Protein Engineering Design and Selection · 116

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Traceless protein splicing utilizing evolved split inteins

2009 · Steve W. Lockless, Tom W. Muir · Proceedings of the National Academy of Sciences · 116

Protein Trans -Splicing as a Means for Viral Vector-Mediated In Vivo Gene Therapy

2008 · Juan Li, Wenchang Sun, et al. · Human Gene Therapy · 114

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Tracking chromatin state changes using nanoscale photo-proximity labelling

2023 · Ciaran P. Seath, Antony J. Burton, et al. · Nature · 108

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Dual-AAV split prime editor corrects the mutation and phenotype in mice with inherited retinal degeneration

2023 · Kaiqin She, Yi Liu, et al. · Signal Transduction and Targeted Therapy · 106

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Works count: 534

Citation count: 11,200