Keyword

STING

Description: An innate immune signaling protein, encoded by STING1, that detects cytosolic DNA signals and helps drive inflammatory responses.

Primary topic: interferon and immune responses (43%)

Wikidata ID: wiki/Q18055374

OpenAlex ID: keywords/sting

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

2012 · Lijun Sun, Jiaxi Wu, et al. · Science · 4,943

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

2008 · Hiroki Ishikawa, Glen N. Barber · Nature · 3,543

STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

2009 · Hiroki Ishikawa, Zhe Ma, et al. · Nature · 2,742

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

2012 · Jiaxi Wu, Lijun Sun, et al. · Science · 2,545

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

2016 · Qi Chen, Lijun Sun, et al. · Nature Immunology · 2,305

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

2014 · Liufu Deng, Hua Liang, et al. · Immunity · 2,168

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Molecular mechanisms and cellular functions of cGAS–STING signalling

2020 · Karl-Peter Hopfner, Veit Hornung · Nature Reviews Molecular Cell Biology · 2,023

Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

2015 · Siqi Liu, Xin Cai, et al. · Science · 1,918

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

2014 · Seng-Ryong Woo, Mercedes B. Fuertes, et al. · Immunity · 1,900

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cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

2013 · Andrea Ablasser, Marion Goldeck, et al. · Nature · 1,675

IFI16 is an innate immune sensor for intracellular DNA

2010 · Leonie Unterholzner, Sinead E Keating, et al. · Nature Immunology · 1,641

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Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

2016 · Christian Lood, Luz P Blanco, et al. · Nature Medicine · 1,563

STING is a direct innate immune sensor of cyclic di-GMP

2011 · Dara L. Burdette, Kathryn M. Monroe, et al. · Nature · 1,563

Mitotic progression following DNA damage enables pattern recognition within micronuclei

2017 · Shane M. Harding, Joseph L. Benci, et al. · Nature · 1,497

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DNA sensing by the cGAS–STING pathway in health and disease

2019 · Mona Motwani, Scott Pesiridis, et al. · Nature Reviews Genetics · 1,463

Activated STING in a Vascular and Pulmonary Syndrome

2014 · Yin Liu, Adriana A. Jesus, et al. · New England Journal of Medicine · 1,419

STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway

2012 · Yasuo Tanaka, Zhijian J. Chen · Science Signaling · 1,319

STING: infection, inflammation and cancer

2015 · Glen N. Barber · Nature reviews. Immunology · 1,302

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The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer

2018 · Tuo Li, Zhijian J. Chen · The Journal of Experimental Medicine · 1,284

RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation

2018 · Danielle A. Sliter, Jennifer Martinez, et al. · Nature · 1,282

Autophagy induction via STING trafficking is a primordial function of the cGAS pathway

2019 · Xiang Gui, Hui Yang, et al. · Nature · 1,260

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

2017 · Selene Glück, Baptiste Guey, et al. · Nature Cell Biology · 1,188

Targeting STING with covalent small-molecule inhibitors

2018 · Simone M. Haag, Muhammet F. Gulen, et al. · Nature · 1,157

Structural basis of STING binding with and phosphorylation by TBK1

2019 · Conggang Zhang, Guijun Shang, et al. · Nature · 1,076

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

2013 · Xu Zhang, Heping Shi, et al. · Molecular Cell · 1,073

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Works count: 7,206

Citation count: 219,400