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Keyword

system xc-

Description: System xc− is a cell-membrane cystine–glutamate antiporter that imports cystine and exports glutamate, with roles in redox balance and cell-death processes.
Wikidata ID: wiki/Q18037569
OpenAlex ID: keywords/system-xc
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
2012 · Scott J. Dixon, Kathryn M. Lemberg, et al. · Cell · 18,468
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CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy
2019 · Weimin Wang, Michael Green, et al. · Nature · 2,846
Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis
2014 · Scott J Dixon, Darpan N Patel, et al. · eLife · 2,061
Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages
2000 · Tetsuro Ishii, Ken Itoh, et al. · Journal of Biological Chemistry · 1,461
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CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
2011 · Takatsugu Ishimoto, Osamu Nagano, et al. · Cancer Cell · 1,191
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Cloning and Expression of a Plasma Membrane Cystine/Glutamate Exchange Transporter Composed of Two Distinct Proteins
1999 · Hideyo Sato, Michiko Tamba, et al. · Journal of Biological Chemistry · 1,110
Ferroptosis is a type of autophagy-dependent cell death
2019 · Borong Zhou, Jiao Liu, et al. · Seminars in Cancer Biology · 1,061
The Cystine/Glutamate Antiporter System x c − in Health and Disease: From Molecular Mechanisms to Novel Therapeutic Opportunities
2012 · Jan Lewerenz, Sandra J. Hewett, et al. · Antioxidants and Redox Signaling · 978
Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis
2022 · Luc Rochette, Geoffrey Dogon, et al. · International Journal of Molecular Sciences · 921
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ATF3 promotes erastin-induced ferroptosis by suppressing system Xc–
2019 · Liyuan Wang, Yichen Liu, et al. · Cell Death and Differentiation · 809
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Signaling pathways and defense mechanisms of ferroptosis
2021 · Jiao Liu, Rui Kang, et al. · FEBS Journal · 787
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AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc– Activity
2018 · Xinxin Song, Shan Zhu, et al. · Current Biology · 746
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Cellular degradation systems in ferroptosis
2021 · Xin Chen, Chunhua Yu, et al. · Cell Death and Differentiation · 628
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Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis
2016 · Hirotaka Imai, Masaki Matsuoka, et al. · Current topics in microbiology and immunology · 623
Ferroptosis
2020 · Daolin Tang, Guido Kroemer · Current Biology · 605
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The oxidative stress-inducible cystine/glutamate antiporter, system x c − : cystine supplier and beyond
2011 · Marcus Conrad, Hideyo Sato · Amino Acids · 599
The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention
2007 · Amanda L. Sheldon, Michael B. Robinson · Neurochemistry International · 595
Glutamate release by primary brain tumors induces epileptic activity
2011 · Susan C Buckingham, Susan L Campbell, et al. · Nature Medicine · 575
Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells
2018 · Yun Sun, Yingfeng Zheng, et al. · Cell Death and Disease · 545
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Electrophile Response Element-mediated Induction of the Cystine/Glutamate Exchange Transporter Gene Expression
2002 · Hiromi Sasaki, Hideyo Sato, et al. · Journal of Biological Chemistry · 542
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System x c ‐ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS
2011 · Richard J Bridges, Nicholas R Natale, et al. · British Journal of Pharmacology · 538
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The Role of Erastin in Ferroptosis and Its Prospects in Cancer Therapy
2020 · Yuechen Zhao, Yanqing Li, et al. · OncoTargets and Therapy · 458
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Loss of cysteinyl-tRNA synthetase (CARS) induces the transsulfuration pathway and inhibits ferroptosis induced by cystine deprivation
2015 · M Hayano, W S Yang, et al. · Cell Death and Differentiation · 458
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Effector T Cells Abrogate Stroma-Mediated Chemoresistance in Ovarian Cancer
2016 · Weimin Wang, Ilona Kryczek, et al. · Cell · 423
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Redox Imbalance in Cystine/Glutamate Transporter-deficient Mice
2005 · Hideyo Sato, Ayako Shiiya, et al. · Journal of Biological Chemistry · 422
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Works count: 1,121
Citation count: 71,210
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