Keyword

T cell development

Description: The processes by which T lymphocytes develop from precursor cells, mature, and acquire functional lineages, primarily in the thymus.

Primary topic: T-cell and B-cell Immunology (63%)

Related topic: T-cell and B-cell Immunology (63%)

OpenAlex ID: keywords/t-cell-development

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 · Young-Yun Kong, Hiroki Yoshida, et al. · Nature · 3,350

RAG-1-deficient mice have no mature B and T lymphocytes

1992 · Peter Mombaerts, John Iacomini, et al. · Cell · 2,932

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 · Scott W. Lowe, Earlene M. Schmitt, et al. · Nature · 2,864

T cell receptor antagonist peptides induce positive selection

1994 · Kristin A. Hogquist, Stephen C. Jameson, et al. · Cell · 2,858

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

1992 · Y Shinkai · Cell · 2,644

Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

2004 · Mehrdad Matloubian, Charles G. Lo, et al. · Nature · 2,579

The Biology of Chemokines and their Receptors

2000 · Devora Rossi, Albert Zlotnik · Annual Review of Immunology · 2,408

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 · A. R. Clarke, C. A. Purdie, et al. · Nature · 2,271

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 · Motonari Kondo, Irving L. Weissman, et al. · Cell · 2,256

A function for interleukin 2 in Foxp3-expressing regulatory T cells

2005 · Jason D Fontenot, Jeffrey P Rasmussen, et al. · Nature Immunology · 1,823

Induction by Antigen of Intrathymic Apoptosis of CD4 + CD8 + TCR lo Thymocytes in Vivo

1990 · Kenneth M. Murphy, Amy B. Heimberger, et al. · Science · 1,735

Human Lymphoid and Myeloid Cell Development in NOD/LtSz- scid IL2R γ null Mice Engrafted with Mobilized Human Hemopoietic Stem Cells,

2005 · Leonard D Shultz, Bonnie L Lyons, et al. · The Journal of Immunology · 1,729

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CD95's deadly mission in the immune system

2000 · Peter H. Krammer · Nature · 1,717

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 · Klaus Pfeffer, Toshifumi Matsuyama, et al. · Cell · 1,679

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 · Martha S. Jordan, Alina Boesteanu, et al. · Nature Immunology · 1,662

SOCS proteins, cytokine signalling and immune regulation

2007 · Akihiko Yoshimura, Tetsuji Naka, et al. · Nature reviews. Immunology · 1,581

NFAT proteins: key regulators of T-cell development and function

2005 · Fernando Macian · Nature reviews. Immunology · 1,572

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 · J J Peschon, P J Morrissey, et al. · The Journal of Experimental Medicine · 1,555

Generalized lymphoproliferative disease in mice, caused by a point mutation in the fas ligand

1994 · Tomohiro Takahashi, Masato Tanaka, et al. · Cell · 1,528

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 · Philippe Bouillet, Donald Metcalf, et al. · Science · 1,503

Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia

1996 · Carrolee Barlow, Shinji Hirotsune, et al. · Cell · 1,458

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Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 · U von Freeden-Jeffry, P Vieira, et al. · The Journal of Experimental Medicine · 1,428

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Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 · Freddy Radtke, Anne Wilson, et al. · Immunity · 1,405

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Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)

2014 · Ludger Klein, Bruno Kyewski, et al. · Nature reviews. Immunology · 1,383

Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3+ T Regulatory Cells

2010 · Angela M Thornton, Patricia E Korty, et al. · The Journal of Immunology · 1,380

Works count: 18,740

Citation count: 677,300