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Keyword

T cell engineering

Description: The genetic or cellular modification of T lymphocytes to alter their recognition, activity, or persistence for therapeutic applications.
OpenAlex ID: keywords/t-cell-engineering
CRISPR-engineered T cells in patients with refractory cancer
2020 · Edward A. Stadtmauer, Joseph A. Fraietta, et al. · Science · 1,467
Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits
2016 · Kole T. Roybal, Levi J. Rupp, et al. · Cell · 1,002
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Clinical use of lentiviral vectors
2018 · Michael C. Milone, Una O’Doherty · Leukemia · 919
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Therapeutic T cell engineering
2017 · Michel Sadelain, Isabelle Rivière, et al. · Nature · 880
Reprogramming human T cell function and specificity with non-viral genome targeting
2018 · Theodore L. Roth, Cristina Puig-Saus, et al. · Nature · 834
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Engineering T Cells with Customized Therapeutic Response Programs Using Synthetic Notch Receptors
2016 · Kole T. Roybal, Jasper Z. Williams, et al. · Cell · 723
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Engineering CAR-T Cells for Next-Generation Cancer Therapy
2020 · Mihe Hong, Justin D. Clubb, et al. · Cancer Cell · 641
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Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications
2017 · Chang Liu, Li Zhang, et al. · Journal of Controlled Release · 607
Engineering CAR-T cells
2017 · Cheng Zhang, Jun Liu, et al. · Biomarker Research · 577
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Navigating CAR-T cells through the solid-tumour microenvironment
2021 · Andrew J. Hou, Laurence C. Chen, et al. · Nature Reviews Drug Discovery · 552
Targeting tumours with genetically enhanced T lymphocytes
2003 · Michel Sadelain, Isabelle Rivière, et al. · Nature reviews. Cancer · 535
Neoantigen T-Cell Receptor Gene Therapy in Pancreatic Cancer
2022 · Rom Leidner, Nelson Sanjuan Silva, et al. · New England Journal of Medicine · 518
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CAR T therapy beyond cancer: the evolution of a living drug
2023 · Daniel J. Baker, Zoltan Arany, et al. · Nature · 506
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Adoptive T Cell Transfer for Cancer Immunotherapy in the Era of Synthetic Biology
2013 · Michael Kalos, Carl H. June · Immunity · 486
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Next-generation regulatory T cell therapy
2019 · Leonardo M. R. Ferreira, Yannick D. Muller, et al. · Nature Reviews Drug Discovery · 477
The promise and potential pitfalls of chimeric antigen receptors
2009 · Michel Sadelain, Renier Brentjens, et al. · Current Opinion in Immunology · 467
Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly
2009 · Hye Joo Kim, Hyung Joo Lee, et al. · Genome Research · 466
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Engineering and Design of Chimeric Antigen Receptors
2018 · Sonia Guedan, Hugo Calderon, et al. · Molecular Therapy — Methods & Clinical Development · 453
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Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy
2010 · Gavin M Bendle, Carsten Linnemann, et al. · Nature Medicine · 449
Programming CAR-T cells to kill cancer
2018 · Louai Labanieh, Robbie G. Majzner, et al. · Nature Biomedical Engineering · 433
A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy
2014 · Brian Philip, Evangelia Kokalaki, et al. · Blood · 398
Emerging Cellular Therapies for Cancer
2018 · Sonia Guedan, Marco Ruella, et al. · Annual Review of Immunology · 388
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes
2018 · Jonathan T. Sockolosky, Eleonora Trotta, et al. · Science · 382
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Engineering of CRISPR-Cas12b for human genome editing
2019 · Jonathan Strecker, Sara Jones, et al. · Nature Communications · 359
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The Role of Extracellular Spacer Regions in the Optimal Design of Chimeric Immune Receptors
2005 · Ryan D Guest, Robert E Hawkins, et al. · Journal of Immunotherapy · 318
Works count: 2,565
Citation count: 42,170
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