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Keyword

tau aggregation

Description: Tau aggregation is the process by which tau proteins assemble into larger deposits, a feature of several neurodegenerative diseases.
OpenAlex ID: keywords/tau-aggregation
Tau in physiology and pathology
2015 · Yipeng Wang, Eckhard Mandelkow · Nature reviews. Neuroscience · 2,235
Cryo-EM structures of tau filaments from Alzheimer’s disease
2017 · Anthony W. P. Fitzpatrick, Benjamin Falcon, et al. · Nature · 2,053
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.
2000 · Luc Buée, Thierry Bussière, et al. · Brain Research Reviews · 2,015
NLRP3 inflammasome activation drives tau pathology
2019 · Christina Ising, Carmen Venegas, et al. · Nature · 1,463
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Tau pathology and neurodegeneration
2013 · Maria Grazia Spillantini, Michel Goedert · The Lancet Neurology · 1,130
Tau-targeting therapies for Alzheimer disease
2018 · Erin E. Congdon, Einar M. Sigurdsson · Nature Reviews Neurology · 1,107
Tau protein liquid–liquid phase separation can initiate tau aggregation
2018 · Susanne Wegmann, Bahareh Eftekharzadeh, et al. · The EMBO Journal · 1,094
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Alzheimer's disease: strategies for disease modification
2010 · Martin Citron · Nature Reviews Drug Discovery · 1,064
Mutation-Specific Functional Impairments in Distinct Tau Isoforms of Hereditary FTDP-17
1998 · M. Hong · Science · 1,003
Roles of tau protein in health and disease
2017 · Tong Guo, Wendy Noble, et al. · Acta Neuropathologica · 1,000
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Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies
2014 · David W. Sanders, Sarah K. Kaufman, et al. · Neuron · 986
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Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
2009 · Diane P. Hanger, Brian H. Anderton, et al. · Trends in Molecular Medicine · 965
Alzheimer's disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules
1996 · Alejandra del C. Alonso, Inge Grundke-Iqbal, et al. · Nature Medicine · 858
Brain homogenates from human tauopathies induce tau inclusions in mouse brain
2013 · Florence Clavaguera, Hiroyasu Akatsu, et al. · Proceedings of the National Academy of Sciences · 760
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Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
2003 · Cathy Andorfer, Yvonne Kress, et al. · Journal of Neurochemistry · 723
The acetylation of tau inhibits its function and promotes pathological tau aggregation
2011 · Todd J. Cohen, Jing L. Guo, et al. · Nature Communications · 722
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Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules
2019 · Benjamin Falcon, Jasenko Zivanov, et al. · Nature · 721
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
2004 · L. Petrucelli · Human Molecular Genetics · 719
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
2005 · Wendy Noble, Emmanuel Planel, et al. · Proceedings of the National Academy of Sciences · 706
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Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies
2016 · Goran Šimić, Mirjana Babić Leko, et al. · Biomolecules · 703
Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
2015 · Erik S Musiek, David M Holtzman · Nature Neuroscience · 689
Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease
2020 · Hendrik Wesseling, Waltraud Mair, et al. · Cell · 685
Interaction between Aβ and Tau in the Pathogenesis of Alzheimer's Disease
2021 · Huiqin Zhang, Wei Wei, et al. · International Journal of Biological Sciences · 679
The release and trans-synaptic transmission of Tau via exosomes
2017 · Yipeng Wang, Varun Balaji, et al. · Molecular Neurodegeneration · 673
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The Neuropathology and Neurobiology of Traumatic Brain Injury
2012 · Kaj Blennow, John Hardy, et al. · Neuron · 665
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Works count: 4,102
Citation count: 154,400
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