Keyword

TCDD

Description: A toxic chemical compound, 2,3,7,8-tetrachlorodibenzo-p-dioxin, studied as an environmental contaminant and for its biological effects.

Primary topic: Toxic Organic Pollutants Impact (50%)

Wikidata ID: wiki/Q52822

OpenAlex ID: keywords/tcdd

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 · A Poland, E Glover, et al. · Journal of Biological Chemistry · 1,369

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 · R.J. Kociba, D.G. Keyes, et al. · Toxicology and Applied Pharmacology · 1,057

Toxic Pollutants from Plastic Waste- A Review

2016 · Rinku Verma, K.S. Vinoda, et al. · Procedia Environmental Sciences · 1,055

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Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

1992 · Herminio Reyes, Suzanne Reisz-Porszasz, et al. · Science · 777

Functional role of AhR in the expression of toxic effects by TCDD

2003 · Junsei Mimura, Yoshiaki Fujii-Kuriyama · Biochimica et Biophysica Acta (BBA) - General Subjects · 746

Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology

2005 · Prabir K. Mandal · Journal of Comparative Physiology B · 604

Cancer Mortality in Workers Exposed to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin

1991 · Marilyn A. Fingerhut, William E. Halperin, et al. · New England Journal of Medicine · 534

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Short-term toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in laboratory animals: effects, mechanisms, and animal models.

1994 · R Pohjanvirta, J Tuomisto · Pharmacological Reviews · 472

Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures

2012 · Mohan Manikkam, Carlos Guerrero-Bosagna, et al. · PLoS ONE · 451

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2,3,7,8-Tetrachlorodibenzo- p -Dioxin Kills Immature Thymocytes by Ca 2+ -Mediated Endonuclease Activation

1988 · David J. McConkey, Pia Hartzell, et al. · Science · 450

Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line

1999 · J. Legler, C. E. van den Brink, et al. · Toxicological Sciences · 430

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Role of the Ah Receptor and the Dioxin‐Inducible [Ah] Gene Battery in Toxicity, Cancer, and Signal Transductiona

1993 · DANIEL W. NEBERT, ALVARO PUGA, et al. · Annals of the New York Academy of Sciences · 423

Teratology studies with 2,4,5-trichlorophenoxyacetic acid and 2,3,7,8-tetrachlorodibenzo-P-dioxin

1971 · K COURTNEY · Toxicology and Applied Pharmacology · 371

In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 · Thomas A. Mably, Donald L. Bjerke, et al. · Toxicology and Applied Pharmacology · 367

In utero and lactational exposure of male rats to 2,3,7,8-tetrachlorodibenzo-p-dioxin

1992 · Thomas A. Mably, Robert W. Moore, et al. · Toxicology and Applied Pharmacology · 365

Early Life Stage Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Zebrafish (Danio rerio)

1997 · Tala R. Henry, Jan M. Spitsbergen, et al. · Toxicology and Applied Pharmacology · 341

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Ah receptor: Dioxin-mediated toxic responses as hints to deregulated physiologic functions

2006 · Karl Walter Bock, Christoph Köhle · Biochemical Pharmacology · 338

Mortality in Current and Former Users of Clozapine

1997 · Alexander M. Walker, Lee L. Lanza, et al. · Epidemiology · 338

Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β

1991 · Thomas R. Sutter, Karen Guzman, et al. · Science · 337

Polychlorinated Biphenyl-77 Induces Adipocyte Differentiation and Proinflammatory Adipokines and Promotes Obesity and Atherosclerosis

2008 · Violeta Arsenescu, Razvan I. Arsenescu, et al. · Environmental Health Perspectives · 336

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Dioxins: WHO’s tolerable daily intake (TDI) revisited

2000 · F.X.Rolaf van Leeuwen, Mark Feeley, et al. · Chemosphere · 336

Microbiome-Derived Tryptophan Metabolites and Their Aryl Hydrocarbon Receptor-Dependent Agonist and Antagonist Activities

2014 · Un-Ho Jin, Syng-Ook Lee, et al. · Molecular Pharmacology · 330

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Dioxin binding activities of polymorphic forms of mouse and human arylhydrocarbon receptors.

1994 · M Ema, N Ohe, et al. · Journal of Biological Chemistry · 329

Role of coactivators in transcriptional activation by the aryl hydrocarbon receptor

2004 · Oliver Hankinson · Archives of Biochemistry and Biophysics · 327

Aryl hydrocarbon receptor-mediated activity of mutagenic polycyclic aromatic hydrocarbons determined using in vitro reporter gene assay

2001 · Miroslav Machala, Jan Vondráček, et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 324

Works count: 5,972

Citation count: 138,800