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Keyword

telomere dysfunction

Description: A biological condition in which telomeres fail to protect chromosome ends, potentially triggering cellular senescence, apoptosis, or genomic instability.
OpenAlex ID: keywords/telomere-dysfunction
A DNA damage checkpoint response in telomere-initiated senescence
2003 · Fabrizio d'Adda di Fagagna, Philip M. Reaper, et al. · Nature · 2,819
Senescent Cells, Tumor Suppression, and Organismal Aging: Good Citizens, Bad Neighbors
2005 · Judith Campisi · Cell · 2,331
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Cellular senescence in ageing: from mechanisms to therapeutic opportunities
2020 · Raffaella Di Micco, Valery Krizhanovsky, et al. · Nature Reviews Molecular Cell Biology · 2,262
Switching and Signaling at the Telomere
2001 · Elizabeth H. Blackburn · Cell · 2,110
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Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
2022 · Jun Guo, Xiuqing Huang, et al. · Signal Transduction and Targeted Therapy · 1,734
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Reversal of human cellular senescence: roles of the p53 and p16 pathways
2003 · Christian M. Beauséjour, Ana Krtolica, et al. · The EMBO Journal · 1,456
DNA Damage Foci at Dysfunctional Telomeres
2003 · Hiroyuki Takai, Agata Smogorzewska, et al. · Current Biology · 1,408
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Telomere dysfunction induces metabolic and mitochondrial compromise
2011 · Ergün Sahin, Simona Colla, et al. · Nature · 1,319
The patterns and dynamics of genomic instability in metastatic pancreatic cancer
2010 · Peter J. Campbell, Shinichi Yachida, et al. · Nature · 1,319
The Shortest Telomere, Not Average Telomere Length, Is Critical for Cell Viability and Chromosome Stability
2001 · Michael T Hemann, Margaret A Strong, et al. · Cell · 1,218
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SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
2008 · Eriko Michishita, Ronald A. McCord, et al. · Nature · 1,111
Cellular Senescence in Aging Primates
2006 · Utz Herbig, Mark Ferreira, et al. · Science · 1,103
p53- and ATM-Dependent Apoptosis Induced by Telomeres Lacking TRF2
1999 · Jan Karlseder, Dominique Broccoli, et al. · Science · 1,086
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
2000 · Steven E. Artandi, Sandy Chang, et al. · Nature · 1,085
The telomere syndromes
2012 · Mary Armanios, Elizabeth H. Blackburn · Nature Reviews Genetics · 983
p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis
1999 · Lynda Chin, Steven E Artandi, et al. · Cell · 979
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The age of cancer
2000 · Ronald A. DePinho · Nature · 958
A crucial role for adipose tissue p53 in the regulation of insulin resistance
2009 · Tohru Minamino, Masayuki Orimo, et al. · Nature Medicine · 889
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
2007 · Eros Lazzerini Denchi, Titia de Lange · Nature · 880
Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice
2010 · Mariela Jaskelioff, Florian L. Muller, et al. · Nature · 857
Telomeres and telomerase: their mechanisms of action and the effects of altering their functions
2004 · Elizabeth H. Blackburn · FEBS Letters · 840
Telomeres and telomerase in cancer
2009 · S. E. Artandi, R. A. DePinho · Carcinogenesis · 823
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Chronic inflammation induces telomere dysfunction and accelerates ageing in mice
2014 · Diana Jurk, Caroline Wilson, et al. · Nature Communications · 800
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Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
2015 · Pedro A. Mateos-Gomez, Fade Gong, et al. · Nature · 767
Linking functional decline of telomeres, mitochondria and stem cells during ageing
2010 · Ergün Sahin, Ronald A. DePinho · Nature · 758
Works count: 2,597
Citation count: 110,000
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