Keyword

telomerase reverse transcriptase

Description: The catalytic protein subunit of telomerase, an enzyme that extends chromosome ends and is studied in genetics, aging, and disease.

Primary topic: Telomeres, Telomerase, and Senescence (39%)

Wikidata ID: wiki/Q7697809

OpenAlex ID: keywords/tert

Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

2017 · Adrian Ally, Miruna Balasundaram, et al. · Cell · 2,483

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Creation of human tumour cells with defined genetic elements

1999 · William C. Hahn, Christopher M. Counter, et al. · Nature · 2,346

Highly Recurrent TERT Promoter Mutations in Human Melanoma

2013 · Franklin W. Huang, Eran Hodis, et al. · Science · 1,816

TERT Promoter Mutations in Familial and Sporadic Melanoma

2013 · Susanne Horn, Adina Figl, et al. · Science · 1,801

Telomere dysfunction induces metabolic and mitochondrial compromise

2011 · Ergün Sahin, Simona Colla, et al. · Nature · 1,319

Inhibition of telomerase limits the growth of human cancer cells

1999 · William C. Hahn, Sheila A. Stewart, et al. · Nature Medicine · 1,030

Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma

2012 · Wing-Kin Sung, Hancheng Zheng, et al. · Nature Genetics · 992

Identification of seven loci affecting mean telomere length and their association with disease

2013 · Veryan Codd, Christopher P Nelson, et al. · Nature Genetics · 934

Adult-onset pulmonary fibrosis caused by mutations in telomerase

2007 · Kalliopi D. Tsakiri, Jennifer T. Cronkhite, et al. · Proceedings of the National Academy of Sciences · 894

Direct activation of TERT transcription by c-MYC

1999 · Kou-Juey Wu, Carla Grandori, et al. · Nature Genetics · 893

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

2012 · Akihiro Fujimoto, Yasushi Totoki, et al. · Nature Genetics · 870

Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis

2013 · Tasha E Fingerlin, Elissa Murphy, et al. · Nature Genetics · 806

Genome-wide association study identifies five susceptibility loci for glioma

2009 · Sanjay Shete, Fay J Hosking, et al. · Nature Genetics · 788

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The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers

2012 · Javier Muñoz, Daniel E Stange, et al. · The EMBO Journal · 772

Integrated genomic characterization of adrenocortical carcinoma

2014 · Guillaume Assié, Eric Letouzé, et al. · Nature Genetics · 731

Mutations in TERT, the Gene for Telomerase Reverse Transcriptase, in Aplastic Anemia

2005 · Hiroki Yamaguchi, Rodrigo T. Calado, et al. · New England Journal of Medicine · 727

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Bone marrow–derived progenitor cells in pulmonary fibrosis

2004 · Naozumi Hashimoto, Hong Jin, et al. · Journal of Clinical Investigation · 720

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Telomerase modulates Wnt signalling by association with target gene chromatin

2009 · Jae-Il Park, Andrew S. Venteicher, et al. · Nature · 706

Protein Composition of Catalytically Active Human Telomerase from Immortal Cells

2007 · Scott B. Cohen, Mark E. Graham, et al. · Science · 670

Myc activates telomerase

1998 · Jing Wang, Lin Ying Xie, et al. · Genes & Development · 653

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Highly prevalent TERT promoter mutations in aggressive thyroid cancers

2013 · Xiaoli Liu, Justin Bishop, et al. · Endocrine Related Cancer · 615

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Systematic analysis of telomere length and somatic alterations in 31 cancer types

2017 · Floris P Barthel, Wei Wei, et al. · Nature Genetics · 613

Sequence variants at the TERT-CLPTM1L locus associate with many cancer types

2009 · Thorunn Rafnar, Patrick Sulem, et al. · Nature Genetics · 609

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DD3(PCA3), a very sensitive and specific marker to detect prostate tumors.

2002 · Jacques B de Kok, Gerald W Verhaegh, et al. · PubMed · 606

The transcription factor GABP selectively binds and activates the mutant TERT promoter in cancer

2015 · Robert J. A. Bell, H. Tomas Rube, et al. · Science · 567

Works count: 9,333

Citation count: 203,700