Keyword

thrombin

Description: Thrombin is a protease enzyme in blood coagulation that converts fibrinogen to fibrin and also affects cellular signaling.

Primary topic: Blood Coagulation and Thrombosis Mechanisms (29%)

Wikidata ID: wiki/Q409166

OpenAlex ID: keywords/thrombin

Thrombin signalling and protease-activated receptors

2000 · Shaun R. Coughlin · Nature · 2,487

Selection of single-stranded DNA molecules that bind and inhibit human thrombin

1992 · Louis C. Bock, Linda C. Griffin, et al. · Nature · 2,470

Mechanisms of Thrombus Formation

2008 · Bruce Furie, Barbara C. Furie · New England Journal of Medicine · 1,928

Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution

2006 · David M. Dohan, Joseph Choukroun, et al. · Oral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology · 1,869

Skepinone-L, a Novel Potent and Highly Selective Inhibitor of p38 MAP Kinase, Effectively Impairs Platelet Activation and Thrombus Formation

2013 · Oliver Borst, Britta Walker, et al. · Cellular Physiology and Biochemistry · 1,860

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A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 · Russell Ross, John Glomset, et al. · Proceedings of the National Academy of Sciences · 1,847

A Modified Spectrophotometric Determination of Chymotrypsin, Trypsin, and Thrombin

1959 · Brian C. W. Hummel · Canadian Journal of Biochemistry and Physiology · 1,839

EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF

1999 · Norbert Prenzel, Esther Zwick, et al. · Nature · 1,506

A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo

2018 · Suping Li, Qiao Jiang, et al. · Nature Biotechnology · 1,478

Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptors

1996 · Henrik Daub, F. Ulrich Weiss, et al. · Nature · 1,476

Endogenous Nitric Oxide Inhibits Human Platelet Adhesion to Vascular Endothelium

1987 · M.W Radomski, R.M.J Palmer, et al. · The Lancet · 1,443

The Pathogenesis of Sepsis

1991 · Roger C. Bone · Annals of Internal Medicine · 1,372

Mechanisms of brain injury after intracerebral haemorrhage

2005 · Guohua Xi, Richard F Keep, et al. · The Lancet Neurology · 1,365

Modulation of endothelial cell hemostatic properties by tumor necrosis factor.

1986 · P P Nawroth, D M Stern · The Journal of Experimental Medicine · 1,311

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Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 · Y A Hannun, C R Loomis, et al. · Journal of Biological Chemistry · 1,156

Proteinase-activated Receptors

2006 · S R Macfarlane, M J Seatter, et al. · Springer eBooks · 1,137

Very fast prediction and rationalization of pKa values for protein–ligand complexes

2008 · Delphine C. Bas, David M. Rogers, et al. · Proteins Structure Function and Bioinformatics · 1,093

Natural protein proteinase inhibitors and their interaction with proteinases

1992 · Wolfram BODE, Robert HUBER · European Journal of Biochemistry · 1,046

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The Roles of Protein C and Thrombomodulin in the Regulation of Blood Coagulation

1989 · C T Esmon · Journal of Biological Chemistry · 1,046

Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide.

1990 · C Boulanger, T F Lüscher · Journal of Clinical Investigation · 1,045

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Protease‐activated receptors in hemostasis, thrombosis and vascular biology

2005 · S.R. COUGHLIN · Journal of Thrombosis and Haemostasis · 1,035

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Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

1974 · Mats Hamberg, Jan Svensson, et al. · Proceedings of the National Academy of Sciences · 989

Fibrin: A Versatile Scaffold for Tissue Engineering Applications

2008 · Tamer A.E. Ahmed, Emma V. Dare, et al. · Tissue Engineering Part B Reviews · 987

A dual thrombin receptor system for platelet activation

1998 · Mark L. Kahn, Yao-Wu Zheng, et al. · Nature · 979

Generation of C5a in the absence of C3: a new complement activation pathway

2006 · Markus Huber-Lang, J Vidya Sarma, et al. · Nature Medicine · 975

Works count: 26,550

Citation count: 819,400