Keyword

TIMP-2

Description: TIMP-2 is a tissue inhibitor of metalloproteinases, a protein that regulates matrix metalloproteinase activity in tissue remodeling and disease.

Primary topic: Protease and Inhibitor Mechanisms (31%)

Wikidata ID: wiki/Q21117628

OpenAlex ID: keywords/timp-2

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 · Z S Galis, G K Sukhova, et al. · Journal of Clinical Investigation · 2,539

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Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 · Alex Y. Strongin, Ivan Collier, et al. · Journal of Biological Chemistry · 1,594

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Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

1997 · D E Gomez, D F Alonso, et al. · PubMed · 1,508

Discovery and validation of cell cycle arrest biomarkers in human acute kidney injury

2013 · Kianoush Kashani, Ali Al-Khafaji, et al. · Critical Care · 1,362

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Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass� 45S5 dissolution

2001 · Ioannis D. Xynos, Alasdair J. Edgar, et al. · Journal of Biomedical Materials Research · 1,235

Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors.

1998 · J P Iredale, R C Benyon, et al. · Journal of Clinical Investigation · 1,071

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Human hepatic stellate cell lines, LX-1 and LX-2: new tools for analysis of hepatic fibrosis

2004 · L Xu, A Y Hui, et al. · Gut · 1,014

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Prevention of cardiac surgery-associated AKI by implementing the KDIGO guidelines in high risk patients identified by biomarkers: the PrevAKI randomized controlled trial

2017 · Melanie Meersch, Christoph Schmidt, et al. · Intensive Care Medicine · 895

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Tissue Inhibitor of Metalloproteinase (TIMP-2)

1989 · W G Stetler-Stevenson, H C Krutzsch, et al. · Journal of Biological Chemistry · 895

Matrix Metalloproteinases and TIMPs Are Associated With Blood-Brain Barrier Opening After Reperfusion in Rat Brain

1998 · G. A. Rosenberg, E. Y. Estrada, et al. · Stroke · 860

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Matrix metalloproteinases and metastasis

1999 · David E. Kleiner, William G. Stetler-Stevenson · Cancer Chemotherapy and Pharmacology · 701

Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1

2001 · Veerle Noë, Barbara Fingleton, et al. · Journal of Cell Science · 695

Growth‐promoting activity of tissue inhibitor of metalloproteinases‐1 (TIMP‐1) for a wide range of cells A possible new growth factor in serum

1992 · Taro Hayakawa, Kyoko Yamashita, et al. · FEBS Letters · 695

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Expression of matrix-metalloproteinases and their inhibitors in the wounds of diabetic and non-diabetic patients

2002 · R. Lobmann, A. Ambrosch, et al. · Diabetologia · 616

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Extracellular matrix 6: Role of matrix metalloproteinases in tumor invasion and metastasis

1993 · William G. Stetler‐Stevenson, Lance A. Liotta, et al. · The FASEB Journal · 596

Shedding of the Matrix Metalloproteinases MMP-2, MMP-9, and MT1-MMP as Membrane Vesicle-Associated Components by Endothelial Cells

2002 · Giulia Taraboletti, Sandra D'Ascenzo, et al. · American Journal Of Pathology · 588

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Human 72-kilodalton type IV collagenase forms a complex with a tissue inhibitor of metalloproteases designated TIMP-2.

1989 · G I Goldberg, B L Marmer, et al. · Proceedings of the National Academy of Sciences · 586

The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

1998 · Georgina S. Butler, Michael J. Butler, et al. · Journal of Biological Chemistry · 574

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The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 · Horst Will, Susan J. Atkinson, et al. · Journal of Biological Chemistry · 569

MMP-2, MT1-MMP, and TIMP-2 are essential for the invasive capacity of human mesenchymal stem cells: differential regulation by inflammatory cytokines

2006 · Christian Ries, Virginia Egea, et al. · Blood · 539

Validation of Cell-Cycle Arrest Biomarkers for Acute Kidney Injury Using Clinical Adjudication

2014 · Azra Bihorac, Lakhmir S. Chawla, et al. · American Journal of Respiratory and Critical Care Medicine · 516

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Interaction of 92-kDa type IV collagenase with the tissue inhibitor of metalloproteinases prevents dimerization, complex formation with interstitial collagenase, and activation of the proenzyme with stromelysin.

1992 · G.I. Goldberg, A Strongin, et al. · Journal of Biological Chemistry · 515

TIMP-2 Mediated Inhibition of Angiogenesis

2003 · Dong-Wan Seo, Hongmei Li, et al. · Cell · 508

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Matrix Metalloproteinase-9 (MMP-9), MMP-2, and Serum Elastase Activity Are Associated With Systolic Hypertension and Arterial Stiffness

2004 · Yasmin, Sharon Wallace, et al. · Arteriosclerosis Thrombosis and Vascular Biology · 501

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Tissue Inhibitors of Metalloproteinases in Cell Signaling: Metalloproteinase-Independent Biological Activities

2008 · William G. Stetler-Stevenson · Science Signaling · 489

Works count: 10,410

Citation count: 279,500