Keyword

TIMP-3

Description: TIMP-3 is a tissue inhibitor of metalloproteinases, a protein that regulates extracellular matrix degradation by inhibiting matrix metalloproteinases.

Primary topic: Protease and Inhibitor Mechanisms (24%)

Wikidata ID: wiki/Q21116458

OpenAlex ID: keywords/timp-3

A gene hypermethylation profile of human cancer.

2001 · M Esteller, P G Corn, et al. · PubMed · 2,034

Tissue inhibitors of metalloproteinases: evolution, structure and function

2000 · Keith Brew, Deendayal Dinakarpandian, et al. · Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology · 1,908

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

1999 · Elizabeth E. Cameron, Kurtis E. Bachman, et al. · Nature Genetics · 1,857

The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases

2020 · Griselda A Cabral-Pacheco, Idalia Garza-Veloz, et al. · International Journal of Molecular Sciences · 1,797

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A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants

2015 · Lars G Fritsche, Wilmar Igl, et al. · Nature Genetics · 1,539

Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.

1997 · D E Gomez, D F Alonso, et al. · PubMed · 1,508

MicroRNA 21 Promotes Glioma Invasion by Targeting Matrix Metalloproteinase Regulators

2008 · Galina Gabriely, Thomas Wurdinger, et al. · Molecular and Cellular Biology · 888

Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma

2018 · Jian Yu, Qing-guo Xu, et al. · Journal of Hepatology · 765

RETRACTED: miR-221&222 Regulate TRAIL Resistance and Enhance Tumorigenicity through PTEN and TIMP3 Downregulation

2009 · Michela Garofalo, Gianpiero Di Leva, et al. · Cancer Cell · 733

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A novel function for tissue inhibitor of metalloproteinases-3 (TIMP3): inhibition of angiogenesis by blockage of VEGF binding to VEGF receptor-2

2003 · Jian Hua Qi, Quteba Ebrahem, et al. · Nature Medicine · 658

Mutations in the tissue inhibitor of metalloproteinases-3 (TIMP3) in patients with Sorsby's fundus dystrophy

1994 · Bernhard H. F. Weber, Gudrun Vogt, et al. · Nature Genetics · 658

TNF‐α converting enzyme (TACE) is inhibited by TIMP‐3

1998 · Augustin Amour, Patrick M Slocombe, et al. · FEBS Letters · 609

Aberrant promoter methylation of multiple genes in non-small cell lung cancers.

2001 · S Zöchbauer-Müller, K M Fong, et al. · PubMed · 608

Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation

2009 · Amber N. Stratman, Kristine M. Malotte, et al. · Blood · 581

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 · Horst Will, Susan J. Atkinson, et al. · Journal of Biological Chemistry · 569

Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17

2007 · Ci-Di Chen, Sonia Podvin, et al. · Proceedings of the National Academy of Sciences · 548

Diverse roles of matrix metalloproteinases and tissue inhibitors of metalloproteinases in neuroinflammation and cerebral ischemia

2008 · E. Candelario-Jalil, Y. Yang, et al. · Neuroscience · 528

TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and Aggrecanase 2 (ADAM-TS5)

2001 · Masahide Kashiwagi, Micky Tortorella, et al. · Journal of Biological Chemistry · 509

Genetic variants near TIMP3 and high-density lipoprotein–associated loci influence susceptibility to age-related macular degeneration

2010 · Wei Chen, Dwight Stambolian, et al. · Proceedings of the National Academy of Sciences · 507

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Tissue inhibitor of metalloproteinases-3 (TIMP-3) is an extracellular matrix-associated protein with a distinctive pattern of expression in mouse cells and tissues.

1994 · K.J. Leco, R. Khokha, et al. · Journal of Biological Chemistry · 480

Injectable and bioresponsive hydrogels for on-demand matrix metalloproteinase inhibition

2014 · Brendan P. Purcell, David Lobb, et al. · Nature Materials · 479

Divergent effects of tissue inhibitor of metalloproteinase-1, -2, or -3 overexpression on rat vascular smooth muscle cell invasion, proliferation, and death in vitro. TIMP-3 promotes apoptosis.

1998 · A H Baker, A B Zaltsman, et al. · Journal of Clinical Investigation · 464

TIMPs: versatile extracellular regulators in cancer

2016 · Hartland W. Jackson, Virginie Defamie, et al. · Nature reviews. Cancer · 454

Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene ( LIPC )

2010 · Benjamin M. Neale, Jesen Fagerness, et al. · Proceedings of the National Academy of Sciences · 443

Localization of degradative enzymes and their inhibitors in the degenerate human intervertebral disc

2004 · Christine Lyn Le Maitre, Anthony J Freemont, et al. · The Journal of Pathology · 443

Works count: 4,065

Citation count: 136,300