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TLR3
Description:
Toll-like receptor 3, an innate immune receptor that recognizes double-stranded RNA and contributes to antiviral signaling in vertebrates.
Primary topic:
Immune Response and Inflammation (29%)
Related topics:
Immune Response and Inflammation (29%),
interferon and immune responses (8%)
OpenAlex ID:
keywords/tlr3
Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
2001
·
Lena Alexopoulou
, Agnieszka Czopik Holt
, et al.
·
Nature
·
6,127
TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells
2006
·
Marc Veldhoen
, Richard J. Hocking
, et al.
·
Immunity
·
3,603
PDF
Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway
2003
·
Masahiro Yamamoto
, Shintaro Sato
, et al.
·
Science
·
3,238
Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA
2005
·
Katalin Karikó
, Michael Buckstein
, et al.
·
Immunity
·
2,716
PDF
IKKε and TBK1 are essential components of the IRF3 signaling pathway
2003
·
Katherine A. Fitzgerald
, Sarah M. McWhirter
, et al.
·
Nature Immunology
·
2,680
TLR signaling pathways
2004
·
Kiyoshi Takeda
, Shizuo Akira
·
Seminars in Immunology
·
2,466
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
2005
·
Etienne Meylan
, Joseph Curran
, et al.
·
Nature
·
2,399
PDF
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
2015
·
Katherine B. Chiappinelli
, Pamela L. Strissel
, et al.
·
Cell
·
2,010
VISA Is an Adapter Protein Required for Virus-Triggered IFN-β Signaling
2005
·
Liang-Guo Xu
, Yan-Yi Wang
, et al.
·
Molecular Cell
·
1,853
PDF
A family of human receptors structurally related to Drosophila Toll
1998
·
Fernando L. Rock
, Gary Hardiman
, et al.
·
Proceedings of the National Academy of Sciences
·
1,728
Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease
2000
·
Elke Cario
, Daniel K. Podolsky
·
Infection and Immunity
·
1,246
A New Mesenchymal Stem Cell (MSC) Paradigm: Polarization into a Pro-Inflammatory MSC1 or an Immunosuppressive MSC2 Phenotype
2010
·
Ruth S. Waterman
, Suzanne L. Tomchuck
, et al.
·
PLoS ONE
·
1,235
PDF
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
2003
·
K. Hoebe
, X. Du
, et al.
·
Nature
·
1,231
Cutting Edge: A Novel Toll/IL-1 Receptor Domain-Containing Adapter That Preferentially Activates the IFN-β Promoter in the Toll-Like Receptor Signaling
2002
·
Masahiro Yamamoto
, Shintaro Sato
, et al.
·
The Journal of Immunology
·
1,227
PDF
Biology of Zika Virus Infection in Human Skin Cells
2015
·
Rodolphe Hamel
, Ophélie Dejarnac
, et al.
·
Journal of Virology
·
1,209
TICAM-1, an adaptor molecule that participates in Toll-like receptor 3–mediated interferon-β induction
2003
·
Hiroyuki Oshiumi
, Misako Matsumoto
, et al.
·
Nature Immunology
·
1,207
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
2003
·
Katherine A. Fitzgerald
, Daniel C. Rowe
, et al.
·
The Journal of Experimental Medicine
·
1,193
PDF
Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus
2006
·
Leonid Gitlin
, Winfried Barchet
, et al.
·
Proceedings of the National Academy of Sciences
·
1,170
TLR3 Deficiency in Patients with Herpes Simplex Encephalitis
2007
·
Shen-Ying Zhang
, Emmanuelle Jouanguy
, et al.
·
Science
·
1,166
Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1–polarizing program in dendritic cells
2005
·
Giorgio Napolitani
, Andrea Rinaldi
, et al.
·
Nature Immunology
·
1,157
Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
2004
·
Tian Wang
, Terrence Town
, et al.
·
Nature Medicine
·
1,155
Recognition of pathogen-associated molecular patterns by TLR family
2003
·
Shizuo Akira
, Hiroaki Hemmi
·
Immunology Letters
·
1,150
Immune evasion by hepatitis C virus NS3/4A protease-mediated cleavage of the Toll-like receptor 3 adaptor protein TRIF
2005
·
Kui Li
, Eileen Foy
, et al.
·
Proceedings of the National Academy of Sciences
·
1,092
mRNA Is an Endogenous Ligand for Toll-like Receptor 3
2004
·
Katalin Karikó
, Houping Ni
, et al.
·
Journal of Biological Chemistry
·
1,062
Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells
2000
·
Marta Muzio
, Daniela Bosisio
, et al.
·
The Journal of Immunology
·
1,060
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Works count:
9,071
Citation count:
322,700
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