Keyword

TLR4

Description: Toll-like receptor 4, an innate immune receptor that recognizes microbial components and helps initiate inflammatory and antimicrobial responses.

Primary topic: Immune Response and Inflammation (22%)

OpenAlex ID: keywords/tlr4

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 · Alexander Poltorak, Xiaolong He, et al. · Science · 7,629

Lipopolysaccharide Endotoxins

2002 · Christian R. H. Raetz, Chris Whitfield · Annual Review of Biochemistry · 4,387

TLR4 links innate immunity and fatty acid–induced insulin resistance

2006 · Hang Shi, Maia V. Kokoeva, et al. · Journal of Clinical Investigation · 3,686

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TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

2006 · Marc Veldhoen, Richard J. Hocking, et al. · Immunity · 3,603

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Cutting Edge: Toll-Like Receptor 4 (TLR4)-Deficient Mice Are Hyporesponsive to Lipopolysaccharide: Evidence for TLR4 as the Lps Gene Product

1999 · Katsuaki Hoshino, Osamu Takeuchi, et al. · The Journal of Immunology · 3,373

Differential Roles of TLR2 and TLR4 in Recognition of Gram-Negative and Gram-Positive Bacterial Cell Wall Components

1999 · Osamu Takeuchi, Katsuaki Hoshino, et al. · Immunity · 3,362

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LPS/TLR4 signal transduction pathway

2008 · Yong-Chen Lu, Wen-Chen Yeh, et al. · Cytokine · 3,290

Resveratrol Reduces the Proinflammatory Effects and Lipopolysaccharide- Induced Expression of HMGB1 and TLR4 in RAW264.7 Cells

2014 · Ying Yang, Shuping Li, et al. · Cellular Physiology and Biochemistry · 3,253

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Role of Adaptor TRIF in the MyD88-Independent Toll-Like Receptor Signaling Pathway

2003 · Masahiro Yamamoto, Shintaro Sato, et al. · Science · 3,238

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

2007 · Lionel Apetoh, François Ghiringhelli, et al. · Nature Medicine · 3,045

The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling

2007 · Luke A. J. O'Neill, Andrew G. Bowie · Nature reviews. Immunology · 2,675

TLR signaling pathways

2004 · Kiyoshi Takeda, Shizuo Akira · Seminars in Immunology · 2,466

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

2012 · Jorge Henao-Mejia, Eran Elinav, et al. · Nature · 2,435

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

2009 · Beom Seok Park, Dong Hyun Song, et al. · Nature · 2,435

Bone marrow stromal cells attenuate sepsis via prostaglandin E2–dependent reprogramming of host macrophages to increase their interleukin-10 production

2008 · Krisztián Németh, Asada Leelahavanichkul, et al. · Nature Medicine · 2,361

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LPS induction of gene expression in human monocytes

2001 · Mausumee Guha, Nigel Mackman · Cellular Signalling · 2,307

Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

2017 · TaChung Yu, Fangfang Guo, et al. · Cell · 2,187

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MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4

1999 · Rintaro Shimazu, Sachiko Akashi, et al. · The Journal of Experimental Medicine · 2,185

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The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 · Adrian Ozinsky, David M. Underhill, et al. · Proceedings of the National Academy of Sciences · 2,085

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans

2000 · Nancy C. Arbour, Eva Lorenz, et al. · Nature Genetics · 2,024

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

2008 · Tatsuya Saitoh, Naonobu Fujita, et al. · Nature · 2,016

Subsets of Human Dendritic Cell Precursors Express Different Toll-like Receptors and Respond to Different Microbial Antigens

2001 · Norimitsu Kadowaki, Stephen Ho, et al. · The Journal of Experimental Medicine · 1,966

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TLR4 enhances TGF-β signaling and hepatic fibrosis

2007 · Ekihiro Seki, Samuele De Minicis, et al. · Nature Medicine · 1,942

Toll-like Receptor-4 Mediates Lipopolysaccharide-induced Signal Transduction

1999 · Jesse C. Chow, Donna W. Young, et al. · Journal of Biological Chemistry · 1,923

A family of human receptors structurally related to Drosophila Toll

1998 · Fernando L. Rock, Gary Hardiman, et al. · Proceedings of the National Academy of Sciences · 1,728

Works count: 49,170

Citation count: 1,545,000