Keyword

TLR5

Description: A pattern-recognition receptor in the Toll-like receptor family that detects bacterial flagellin and helps trigger innate immune and inflammatory responses.

Primary topic: Immune Response and Inflammation (37%)

OpenAlex ID: keywords/tlr5

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

2001 · Fumitaka Hayashi, Kelly D. Smith, et al. · Nature · 3,604

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

2010 · Matam Vijay-Kumar, Jesse D. Aitken, et al. · Science · 2,071

A family of human receptors structurally related to Drosophila Toll

1998 · Fernando L. Rock, Gary Hardiman, et al. · Proceedings of the National Academy of Sciences · 1,728

Cutting Edge: Bacterial Flagellin Activates Basolaterally Expressed TLR5 to Induce Epithelial Proinflammatory Gene Expression

2001 · Andrew T Gewirtz, Tony A Navas, et al. · The Journal of Immunology · 1,346

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Differential Alteration in Intestinal Epithelial Cell Expression of Toll-Like Receptor 3 (TLR3) and TLR4 in Inflammatory Bowel Disease

2000 · Elke Cario, Daniel K. Podolsky · Infection and Immunity · 1,246

Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1β in salmonella-infected macrophages

2006 · Luigi Franchi, Amal Amer, et al. · Nature Immunology · 1,131

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

2006 · Edward A Miao, Celia M Alpuche-Aranda, et al. · Nature Immunology · 1,126

Toll-like receptor–mediated cytokine production is differentially regulated by glycogen synthase kinase 3

2005 · Michael Martin, Kunal Rehani, et al. · Nature Immunology · 1,081

Differential Expression and Regulation of Toll-Like Receptors (TLR) in Human Leukocytes: Selective Expression of TLR3 in Dendritic Cells

2000 · Marta Muzio, Daniela Bosisio, et al. · The Journal of Immunology · 1,060

Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis

2013 · Malin E V Johansson, Jenny K Gustafsson, et al. · Gut · 1,003

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Regulatory T Cells Selectively Express Toll-like Receptors and Are Activated by Lipopolysaccharide

2003 · Iris Caramalho, Thiago Lopes-Carvalho, et al. · The Journal of Experimental Medicine · 970

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The adaptor molecule TIRAP provides signalling specificity for Toll-like receptors

2002 · Tiffany Horng, Gregory M. Barton, et al. · Nature · 809

Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility

2003 · Kelly D Smith, Erica Andersen-Nissen, et al. · Nature Immunology · 808

Bacterial flagellin is a dominant antigen in Crohn disease

2004 · Michael J. Lodes, Yingzi Cong, et al. · Journal of Clinical Investigation · 799

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Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

2008 · Satoshi Uematsu, Kosuke Fujimoto, et al. · Nature Immunology · 746

Cutting Edge: Different Toll-Like Receptor Agonists Instruct Dendritic Cells to Induce Distinct Th Responses via Differential Modulation of Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Kinase and c-Fos

2003 · Sudhanshu Agrawal, Anshu Agrawal, et al. · The Journal of Immunology · 725

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An Agonist of Toll-Like Receptor 5 Has Radioprotective Activity in Mouse and Primate Models

2008 · Lyudmila G. Burdelya, Vadim I. Krivokrysenko, et al. · Science · 706

Evasion of Toll-like receptor 5 by flagellated bacteria

2005 · Erica Andersen-Nissen, Kelly D. Smith, et al. · Proceedings of the National Academy of Sciences · 657

A Common Dominant TLR5 Stop Codon Polymorphism Abolishes Flagellin Signaling and Is Associated with Susceptibility to Legionnaires' Disease

2003 · Thomas R. Hawn, Annelies Verbon, et al. · The Journal of Experimental Medicine · 609

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Structural Basis of TLR5-Flagellin Recognition and Signaling

2012 · Sung-il Yoon, Oleg Kurnasov, et al. · Science · 582

A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion

2016 · George M. H. Birchenough, Elisabeth E. L. Nyström, et al. · Science · 564

Toll‐like receptor expression in murine DC subsets: lack of TLR7 expression by CD8α + DC correlates with unresponsiveness to imidazoquinolines

2003 · Alexander D. Edwards, Sandra S. Diebold, et al. · European Journal of Immunology · 551

Flagellin perception: a paradigm for innate immunity

2002 · Lourdes Gómez-Gómez, Thomas Boller · Trends in Plant Science · 551

Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

2010 · Alexander Panda, Feng Qian, et al. · The Journal of Immunology · 547

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TLR5-Mediated Sensing of Gut Microbiota Is Necessary for Antibody Responses to Seasonal Influenza Vaccination

2014 · Jason Z. Oh, Rajesh Ravindran, et al. · Immunity · 539

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Works count: 3,475

Citation count: 121,700